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Rhumatologue

Professeur Marie-Hélène LAFAGE

📍 Saint-Étienne (42)SalariéRPPS 10003013058
📊 Reconnaissance scientifique : 49/100📝 220 articles publiés📚 HAL (8)📕 1 livre🎓 1 thèse dirigée

✨ Profil synthétique

IA · 06/05/2026

Le Professeur Marie-Hélène LAFAGE est un rhumatologue à Saint-Étienne avec une expertise reconnue dans le domaine de la santé osseuse et des maladies métaboliques. Ses recherches se concentrent notamment sur l'ostéoporose, les troubles parathyroïdiens et le métabolisme osseux. Avec un h-index de 49 et plus de 220 publications, elle démontre une activité de recherche significative.

Expertises présumées

  • Ostéoporose
  • Ostéomalacie
  • Sclérodermie
  • Troubles parathyroïdiens
  • Métabolisme osseux
  • Recherche sur la vitamine D

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

Diplômes

🎓 DES & spécialité ordinale

  • Rhumatologie (SM)

📚 CES (Certificat d'Études Spéciales)

  • CES Rhumatologie

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Direction de thèses

🎓 1 thèse dirigée

Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

49

h articles cités ≥ h fois chacun. Un h de 49 = 49 publications avec 49+ citations.

Citations

8 511

Publications

220

i10-index

111

Thématiques principales

  • Bone health and osteoporosis research ×74
  • Parathyroid Disorders and Treatments ×54
  • Bone Metabolism and Diseases ×54
  • Bone health and treatments ×49
  • Vitamin D Research Studies ×27

Affiliations FR : Institute Cancer De La Loire Lucien Neuwirth · Université Jean Monnet

Voir sur OpenAlex ↗🆔 ORCID 0000-0002-2091-3961

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Livres & ouvrages

Source : Google Books — filtre catégories médicales/santé/sciences.

Lieux de consultation

  • CENTRE DE SANTE FILIERIS DE ST-ETIENNE

    7 Avenue AUGUSTIN DUPRE, 42100 Saint-Étienne

    ☎ 0477435952Salarié (centre de santé)

  • HOPITAL NORD - CHU42

    Avenue ALBERT RAIMOND, 42277 Saint-Priest-en-Jarez

    ☎ 0477828002Hospitalier

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

📊 Comprendre le remboursement

Prendre rendez-vous & contact

🗓 Trouver sur Doctolib📇 Ajouter à mes contacts

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Top publications · les plus citées

  • 1
    Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study

    The Journal of clinical investigation · 1995

    📚 79 citations🎯 RCR 3.12Top 15% NIH🔓 Open Access📄 PDF gratuit ↗
  • 2
    Effects of sodium fluoride and alendronate on the bone mineral in minipigs: a small-angle X-ray scattering and backscattered electron imaging study

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1996

    📚 65 citations🎯 RCR 2.49Top 20% NIH
    Lire l'abstract Crossref ↓

    Abstract Sodium fluoride (NaF), which stimulates bone formation, and bisphosphonates, which reduce bone resorption, are both used in the treatment of osteoporosis, and are binding to bone mineral. In this study, using small-angle X-ray scattering and backscattered electron imaging, we analyzed the bone mineral in the vertebrae of minipigs treated with fluoride, with the bisphosphonate alendronate (ALN), or with vehicle. All specimens were investigated blindly. A slight increase in the average thickness of the mineral crystals as well as changes in the structure of the mineral/collagen composite were found in the case of fluoride-treated animals. No differences were found between ALN-treated animals and controls. The changes produced by fluoride are in the same direction as seen in bones from patients treated with NaF, albeit much smaller. They also correlate quantitatively with the reduction in biomechanical properties of bone in fluoride-treated minipigs found in an earlier study with the same animals. These findings suggest that small changes in the structure of the mineral/collagen composite in bone may considerably affect its biomechanical properties. It also emphasizes the delicate balance between the increase of bone mass and deterioration of bone material properties for the effect of fluoride on the biomechanical properties of bone.

  • 3
    Architectural modifications and cellular response during disuse-related bone loss in calcaneus of the sheep

    Journal of applied physiology (Bethesda, Md. : 1985) · 1996

    📚 23 citations
    Lire l'abstract Crossref ↓

    The results of simple biomechanical unloading in models of acute-disuse osteoporosis are influenced by systemic and regional effects of the method used to generate the bone loss. A model in which strain-gauge measurements confirmed that the os calcis was unloaded in healthy ewes during ambulation was assessed by histomorphometry. Twelve nonovariectomized adult female Welsh mountain sheep were submitted to hock joint immobilization by an external fixation procedure from the tibia to the metatarsus for a period of 12 wk. Histomorphometric analysis showed that this model was able to produce pure local bone loss, as transiliac bone biopsies failed to reveal any difference between the initial and final results. Immobilized and nonimmobilized calcanei were both removed postmortem. After the 12 wk of the study, osteoclastic activity was increased in accordance with the usual disuse process. An unexpected increase of osteoblastic activity was also observed, possibly related to recovery after the initial dramatic bone loss, but an artifact of the surgical procedure such as a regional acceleration phenomenon cannot be definitively excluded. However, the increased osteoblastic activity was not sufficient to prevent accentuation of the negative bone balance, resulting in a 29% decrease of trabecular bone volume in immobilized calcanei compared with nonimmobilized calcanei. This reduction was due to thinning of trabeculae (72.4 +/- 12.1 vs. 98.9 +/- 15.9 microns; P < 0.05) without any change in trabecular number (2.74 +/- 0.72 vs. 2.79 +/- 0.40/mm2; not significant). In conclusion, this model only locally increased both osteoclastic and osteoblastic activities leading to bone loss and architectural modifications. The decreased bone formation usually observed in other models of disuse osteoporosis may therefore not constitute a local phenomenon generated by unloading.

Publications scientifiques (8) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal6

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Ostéomalacie1

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Sclérodermie1

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