📇 Rhumatologue · POITIERS · (86) · Mixte

M GUILLAUME LADOUGNE

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Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
22 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
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2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
124.6 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 POITIERS (86)MixteRPPS 10100906303

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR GUILLAUME LADOUGNE
109 AVENUE DE LA LIBERATION, 86000 POITIERS
Activité de soin et de pharmacie
CHU LA MILETRIE
2 R DE LA MILETRIE CS 90577, 86021 POITIERS CEDEX
☎ 0549444444Activité de soin et de pharmacie🏥 Centre CHU ↗

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Top publications · les plus citées

Association between obstructive sleep apnea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease

Sleep · 2026

📚 5 citations🎯 RCR 5.00

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Abstract Study Objectives The association between obstructive sleep apnea (OSA) and liver fibrosis has been primarily evaluated using noninvasive tools or in selected populations (bariatric surgery). The aim of the study was to determine whether OSA is associated with liver fibrosis in patients with suspected nonalcoholic fatty liver disease (NAFLD) referred for liver biopsy (LB). Methods Patients who underwent percutaneous LB for suspected NAFLD were prospectively included and investigated by in-lab polysomnography. Liver lesions were evaluated using the NASH-CRN scoring system and advanced fibrosis was defined as F ≥ 3. Moderate to severe OSA was defined by an apnea–hypopnea index (AHI) ≥15 events/h. Results Among the 97 patients included in the study, 40 exhibited advanced fibrosis, while 63 demonstrated moderate to severe OSA. The prevalence of moderate to severe OSA in patients with advanced fibrosis was 82% versus 52% in patients with F0–2 fibrosis stage (p &lt; .0037). The association between moderate to severe OSA and advanced fibrosis remained significant after adjustment for sex, age, diabetes and obesity with an OR of 3.48 (CI = 1.03% to 11.83%; p = .045). Similar association was found with nocturnal hypoxia markers (oxygen desaturation index and the time spent under 90% of saturation). No association was observed between moderate to severe OSA and steatosis or nonalcoholic steatohepatitis. Conclusions Utilizing the gold-standard tools for OSA and NAFLD diagnosis in a multicentric cohort of biopsy-proven NAFLD patients, an independent association between OSA and liver fibrosis was confirmed. Statement of Significance This study provides the strongest evidence to date that obstructive sleep apnea (OSA) is independently associated with advanced liver fibrosis in patients with biopsy-proven NAFLD. Unlike prior studies based on indirect measures or bariatric populations, this work used gold-standard diagnostics—full polysomnography and liver histology—in a general NAFLD cohort. The high prevalence of OSA among patients with advanced fibrosis suggests systematic screening may be warranted. These findings identify OSA as a potential modifiable risk factor for liver disease progression.

Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study

Pain · 2026

📚 3 citations🩺 Clinique🔓 Open Access

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Abstract Complex regional pain syndrome (CRPS) is a challenging condition with unpredictable clinical evolution. Identifying early prognostic factors could transform patient management and improve outcomes. This prospective study followed 113 patients with early CRPS (<6 months) over 1 year to assess clinical evolution and investigate key predictors of chronification. Participants underwent repeated clinical assessments, quantitative sensory testing, and self-reported evaluations at 4 time points over 1 year. Multivariable mixed-effect models were used to identify independent early prognostic factors. Despite some improvement, 35% of the participants still met Budapest criteria at 1 year, with persistent pain, disability, and impaired quality of life. Sensory profiles appeared to stabilize after a few months, while body perception disturbance scores did not change during the follow-up period. Psychosocial factors, such as baseline disability, psychosocial severity, and social support, as well as body mass index and allodynia, were predictors of long-term outcomes. Biopsychosocial Early CRPS profiles defined through a latent class analysis carried out on the basis of data measured at inclusion revealed distinct clinical trajectories and showed stronger prognostic value than previously suggested CRPS classifications (eg, based on skin temperature). These findings highlight the importance of an early assessment incorporating biopsychosocial elements to stratify risk and tailor interventions. Our study paves the way for the development of a clinical tool to predict CRPS evolution, potentially enabling tailored treatments. Future research should validate these predictive models and explore their integration into routine practice, potentially improving the management of early CRPS.

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M GUILLAUME LADOUGNE

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Top publications · les plus citées

Publications scientifiques (22) — classées par pathologie

Transversal11

Pédiatrie5

Essai clinique2

Gériatrie1

IRM ostéo-articulaire1

Pharmacovigilance1

Revue générale1

Santé mentale / fatigue1

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