📇 Rhumatologue · LE HAVRE · (76) · Libéral

M FREDERICK JAN

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Auteur de référence en rhumatologie
21 articles scientifiques publiés — un praticien à la pointe de la recherche
En plein centre-ville
LE HAVRE (76600) — accessible depuis tout le bassin urbain
Délais de RDV courts dans la région
119.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LE HAVRE (76)LibéralRPPS 10001915122

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer

Gynecologic oncology · 2025

📚 8 citations🎯 RCR 2.91🔓 Open Access📄 PDF gratuit ↗

The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks

Genome biology · 2026

📚 2 citations🔓 Open Access

Laser Interstitial Thermal Therapy for the Treatment of Mesial Temporal Lobe Epilepsy in Children

Journal of child neurology · 2025

📚 2 citations

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Objective Few studies have explored the efficacy of laser interstitial thermal therapy in pediatric epilepsy surgery. This study aims to evaluate seizure-free outcomes in children and adolescents with mesial temporal lobe epilepsy who underwent laser interstitial thermal therapy. Methods This was a retrospective cohort study performed at a level 4 epilepsy center. All patients had comprehensive presurgical epilepsy evaluations with a consensus treatment decision made by a multidisciplinary team. Brain magnetic resonance imaging (MRI) data were used to determine lesional vs nonlesional groups. All laser interstitial thermal therapy procedures were performed using Visualase laser ablation systems by the neurosurgical team. Seizure-free outcomes were measured according to the Engel surgical outcome scale. Results This study included 19 patients (12 girls, 7 boys). Age of epilepsy onset ranged from 2 to 17 years (mean 9.9 years), and age at time of surgery ranged from 8 to 20 years (mean 15.1 years). Ten patients (52.5%) had signs of hippocampal sclerosis on MRI (lesional group), and 9 patients (47.5%) had a normal brain MRI (nonlesional group). Engel 1 score was achieved by 14 of 19 patients (73.5%): 9 of 10 patients (90%) in the lesional group and 5 of 9 patients (55.5%) in the nonlesional group. Younger age of seizure onset was a predictor of better postsurgical outcome, but no other outcome predictors could be established. Conclusion Laser interstitial thermal therapy is safe and effective for the treatment of drug-resistant mesial temporal lobe epilepsy in children, rendering more favorable seizure-free outcomes in pediatric patients with hippocampal atrophy than in those with nonlesional mesial temporal lobe epilepsy.

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M FREDERICK JAN

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Top publications · les plus citées

Publications scientifiques (21) — classées par pathologie

Pédiatrie8

Transversal6

Revue générale3

Santé mentale / fatigue2

Économie santé1

Épidémiologie & registres1

Essai clinique1

Fièvres auto-inflammatoires1

Génétique1

Vraie vie / RWE1

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