📇 Rhumatologue · COMPIEGNE CEDEX · (60) · Libéral

MME CATALINA ILIESCU-CONSTANTINESCU

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27 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 COMPIEGNE CEDEX (60)LibéralRPPS 10004026521

✨ Génération du profil synthétique IA en cours…

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CH CHICN COMPIÈGNE
ZAC DE MERCIÈRE - ZONE 3 8 AV HENRI ADNOT BP 50 029, 60321 COMPIEGNE CEDEX
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SELARL DU DOCTEUR CATALINA ILIESCU
CABINET MEDICAL 19-21RUE DE L'OISE RUE DE L OISE, 60200 COMPIEGNE

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Top publications · les plus citées

Analysis of transcriptomic features reveals molecular endotypes of SLE with clinical implications

Genome medicine · 2023

📚 22 citations🎯 RCR 2.25Top 23% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Systemic lupus erythematosus (SLE) is known to be clinically heterogeneous. Previous efforts to characterize subsets of SLE patients based on gene expression analysis have not been reproduced because of small sample sizes or technical problems. The aim of this study was to develop a robust patient stratification system using gene expression profiling to characterize individual lupus patients. Methods We employed gene set variation analysis (GSVA) of informative gene modules to identify molecular endotypes of SLE patients, machine learning (ML) to classify individual patients into molecular subsets, and logistic regression to develop a composite metric estimating the scope of immunologic perturbations. SHapley Additive ExPlanations (SHAP) revealed the impact of specific features on patient sub-setting. Results Using five datasets comprising 2183 patients, eight SLE endotypes were identified. Expanded analysis of 3166 samples in 17 datasets revealed that each endotype had unique gene enrichment patterns, but not all endotypes were observed in all datasets. ML algorithms trained on 2183 patients and tested on 983 patients not used to develop the model demonstrated effective classification into one of eight endotypes. SHAP indicated a unique array of features influential in sorting individual samples into each of the endotypes. A composite molecular score was calculated for each patient and significantly correlated with standard laboratory measures. Significant differences in clinical characteristics were associated with different endotypes, with those with the least perturbed transcriptional profile manifesting lower disease severity. The more abnormal endotypes were significantly more likely to experience a severe flare over the subsequent 52 weeks while on standard-of-care medication and specific endotypes were more likely to be clinical responders to the investigational product tested in one clinical trial analyzed (tabalumab). Conclusions Transcriptomic profiling and ML reproducibly separated lupus patients into molecular endotypes with significant differences in clinical features, outcomes, and responsiveness to therapy. Our classification approach using a composite scoring system based on underlying molecular abnormalities has both staging and prognostic relevance.

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

Cell death & disease · 2023

📚 11 citations🎯 RCR 1.18🔓 Open Access📄 PDF gratuit ↗

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AbstractPediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience a relapse. It is not possible to improve prognosis only with further intensification of chemotherapy, as come with a severe cost to the health of patients, often resulting in treatment-related death or long-term sequels. To design more effective and less toxic therapies we need a better understanding of pediatric AML biology. The NUP98-KDM5A chimeric protein is exclusively found in a particular subgroup of young pediatric AML patients with complex karyotypes and poor prognosis. In this study, we investigated the impact of NUP98-KDM5A expression on cellular processes in human Pluripotent Stem Cell models and a patient-derived cell line. We found that NUP98-KDM5A generates genomic instability through two complementary mechanisms that involve accumulation of DNA damage and direct interference of RAE1 activity during mitosis. Overall, our data support that NUP98-KDM5A promotes genomic instability and likely contributes to malignant transformation.

Use of a Bipolar Device (LigaSure) to Seal the Appendiceal Stump in Pediatric Laparoscopic Appendectomy: 10-year Latin-American Experience

Journal of pediatric surgery · 2023

📚 6 citations🎯 RCR 2.72Top 18% NIH

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Publications scientifiques (27) — classées par pathologie

Transversal7

Case report / série6

Pédiatrie5

Lupus4

Revue générale3

Corticothérapie1

Pharmacovigilance1

Santé mentale / fatigue1

SAPL1

Vascularites des gros vaisseaux1

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