📇 Rhumatologue · QUIMPER CEDEX · (29) · Salarié
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3 raisons identifiées
Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
Expérience confirmée
35 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
146.3 rhumatos / 100 000 hab. — département bien doté
35ans d'exercice (thèse 1991)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Direction : Paul Basset
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Inflammatory optic neuropathy in granulomatosis with polyangiitis can mimick isolated idiopathic optic neuritis
2019ArticleEuropean Journal of Ophthalmology
Observational Study of a French and Belgian Multicenter Cohort of 23 Patients Diagnosed in Adulthood With Mevalonate Kinase Deficiency
2016ArticleMedicine
Efficacy and safety of pegylated-interferon α-2a in myelofibrosis: a study by the FIM and GEM French cooperative groups.
2013ArticleBritish Journal of Haematology
Mononeuritis multiplex in a patient with B-cell prolymphocytic leukaemia: a diagnostic challenge.
2013ArticleBMJ Case Rep
Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy.
2012ArticleAnnals of Hematology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CHIC QUIMPER
14 AV YVES THEPOT, 29107 QUIMPER CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Arthritis and rheumatism · 2007
AbstractObjectiveTreatment with rituximab depletes B cells from the peripheral blood (PB) and salivary glands (SGs) of patients with primary Sjögren's syndrome (SS). The purpose of this study was to track the repopulation of B cell subsets in PB as well as their subsequent homing into SGs in patients with primary SS treated with rituximab.MethodsA series of 4‐color flow cytometry experiments delineated B cell subsets in 15 patients with primary SS. All were tested on days 8 and 15 of treatment. Nine of the patients were followed up monthly for 10 months, and the remaining 6 patients were followed up monthly for 24 months. Enzyme‐linked immunosorbent assays were developed to measure serum levels of BAFF and rituximab. SGs were biopsied at the start of the study and 4 months after treatment in 15 patients, 12 months after treatment in 3 patients, and 24 months after treatment in 2 patients.ResultsBaseline serum levels of BAFF correlated inversely (r = −0.92, P < 5 × 10−4) with the duration of B cell depletion: the higher the BAFF levels, the shorter the duration of B cell depletion. Four B cell subsets repopulated the PB: plasmablasts (CD19+, CD5−,IgD−,CD38++), transitional type 1 (T1) B cells (CD19+,CD5+,IgD+,CD38++), mature Bm2 cells (CD19+,CD5+/−,IgD+,CD38+/−), and memory B cells (CD19+,CD5−,IgD−,CD38−). Increased numbers of Bm2 cells and decreased memory B cells reappeared with time. Sequential SG biopsies revealed that B cells were absent in these glands for 12 months: they were detected 24 months after rituximab treatment. Memory and T1 B cells were the first B cells identified locally.ConclusionThe timing of B cell repopulation is modulated by BAFF and is followed by reconstitution of the preexisting abnormalities.
Arthritis and rheumatism · 2007
AbstractObjectiveTo identify the cells that produce BAFF in the salivary glands of patients with primary Sjögren's syndrome (SS), and to analyze BAFF receptor expression by local T and B lymphocytes.MethodsWe used 3 methods to identify the source of BAFF: in situ hybridization of the transcripts for BAFF combined with staining of membrane markers, regular and real‐time reverse transcription–polymerase chain reaction (RT‐PCR) of cultured epithelial cells, and RT‐PCR of sorted single‐cell T and B lymphocytes eluted from salivary glands. Cells expressing TACI, BCMA, and B lymphocyte stimulator receptor 3 (BR‐3) were disclosed by combining each specific staining of the receptors with each specific staining of the cells. The function of BAFF generated by epithelial cells on B lymphocytes was determined in short‐term cocultures.ResultsTranscripts for BAFF were seen in epithelial cells and infiltrating T lymphocytes and, for the first time, were detected in local B cells. It is interesting that BR‐3 was present on these B cells but not on T cells. In contrast, TACI and, to a lesser degree, BCMA were observed on transitional B lymphocytes, whereas T lymphocytes were devoid of receptors for BAFF. Furthermore, this cytokine was shown to be functional, in that epithelial cell–bound BAFF extended the survival of normal B cells, but cell‐free BAFF released in the supernatants did not.ConclusionThese experiments establish that in primary SS, BAFF is produced not only by epithelial cells and T cells but also by B cells. The expression of receptors for BAFF would thus allow these receptors to participate in an autocrine pattern of self‐stimulation.
Arthritis and rheumatism · 2006
AbstractObjectiveTo identify B cell subpopulations participating in the lymphocyte infiltrate of salivary glands from patients with primary Sjögren's syndrome. A special emphasis was placed on those B lymphocytes included in the ectopic germinal centers (GCs).MethodsThe presence of B cells in salivary glands and their polyclonality were ascertained by phenotyping and reverse transcription–polymerase chain reaction in salivary gland samples from 18 patients. Their phenotype was thoroughly analyzed using a number of double‐staining combinations. The results obtained in tissue sections were confirmed by fluorescence‐activated cell sorting analysis of B cells eluted from salivary glands, and these findings were compared with those in tonsils.ResultsMemory‐type B cells were defined as CD20+,CD27+ and were seen in all specimens, whereas GCs were found in only 7 specimens. Furthermore, B cells found in these GCs lacked certain characteristics of centroblasts and centrocytes. Instead, they fulfilled the criteria for transitional type II (TII) B cells and resembled marginal‐zone B cells. BAFF (the assistance of which is required for proper transformation of transitional TI B cells into transitional TII B cells) accumulated adjacent to transitional and marginal‐zone–like B lymphocytes. Further evidence for the involvement of BAFF came from the expression of its receptors on infiltrating B cells.ConclusionThese transitional TII and marginal‐zone–like B cells are probably instrumental in the local production of autoantibodies and possibly influential in the ensuing destruction of epithelial cells.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Annals of hematology · 2022 · Case Reports
Le Calloch R, Arnaud B, Le Clech L, Hutin P, et al.
Annals of hematology · 2021 · Case Reports
Herbreteau L, Le Calloch R, Arnaud B, Cassou N, et al.
Medicine · 2016 · Journal Article
Durel CA, Aouba A, Bienvenu B, Deshayes S, et al.
BMJ case reports · 2014 · Case Reports
Le Clech L, Hutin P, Le Gal S, Guillerm G
BMJ case reports · 2013 · Case Reports
Le Clech L, Rizcallah MJ, Alavi Z, Hutin P
AIDS (London, England) · 2004 · Case Reports
Plantier JC, Lemée V, Dorval I, Gueudin M, et al.
Clinical reviews in allergy & immunology · 2007 · Journal Article
Youinou P, Devauchelle V, Hutin P, Le Berre R, et al.
Arthritis and rheumatism · 2007 · Controlled Clinical Trial
Pers JO, Devauchelle V, Daridon C, Bendaoud B, et al.
Arthritis and rheumatism · 2007 · Journal Article
Daridon C, Devauchelle V, Hutin P, Le Berre R, et al.
Annals of hematology · 2012 · Journal Article
Cornec D, Tempescul A, Querellou S, Hutin P, et al.
Arthritis and rheumatism · 2007 · Controlled Clinical Trial
Pers JO, Devauchelle V, Daridon C, Bendaoud B, et al.
International archives of allergy and immunology · 1994 · Comparative Study
Hutin P, Lamour A, Pennec YL, Soubrane C, et al.
British journal of haematology · 2013 · Journal Article
Ianotto JC, Boyer-Perrard F, Gyan E, Laribi K, et al.
Arthritis and rheumatism · 2006 · Journal Article
Daridon C, Pers JO, Devauchelle V, Martins-Carvalho C, et al.