📇 Rhumatologue · MULHOUSE CEDEX 2 · (68) · Libéral

MME TINA HESSAMFAR-MOSTOUFIZADEH

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Auteur de référence en rhumatologie
22 articles scientifiques publiés — un praticien à la pointe de la recherche
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📍 MULHOUSE CEDEX 2 (68)LibéralRPPS 10100871689

✨ Génération du profil synthétique IA en cours…

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CLINIQUE DIACONAT ROOSEVELT 14 BOULEVARD DU PRESIDENT ROOSEVELT, 68067 MULHOUSE CEDEX 2
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Top publications · les plus citées

Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial

The Lancet. Infectious diseases · 2023

📚 31 citations🎯 RCR 4.28Top 10% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Ceftazidime-Avibactam Treatment for Klebsiella pneumoniae Bacteremia in Preterm Infants in NICU: A Clinical Experience

Antibiotics (Basel, Switzerland) · 2023

📚 15 citations🎯 RCR 3.16Top 15% NIH🔓 Open Access📄 PDF gratuit ↗

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Ceftazidime/avibactam (CAZ/AVI) is an antibiotic combination approved for the treatment of several infections caused by multi-drug resistant (MDR) Gram-negative bacteria. Neonates admitted to the Neonatal Intensive Care Unit (NICU) are at high risk of developing bacterial infections, and the choice of appropriate antibiotics is crucial. However, the use of antibiotics in neonates carries risks such as antibiotic resistance and disruption of gut microbiota. This study aimed to assess the safety and efficacy of CAZ/AVI in preterm infants admitted to the NICU. Retrospective data from preterm infants with Klebsiella pneumoniae bacteremia who received CAZ/AVI were analyzed. Clinical and microbiological responses, adverse events, and outcomes were evaluated. Eight patients were included in the study, all of whom showed clinical improvement and achieved microbiological cure with CAZ/AVI treatment. No adverse drug reactions were reported. Previous antibiotic therapies failed to improve the neonates’ condition, and CAZ/AVI was initiated based on clinical deterioration and epidemiological considerations. The median duration of CAZ/AVI treatment was 14 days, and combination therapy with fosfomycin or amikacin was administered. Previous case reports have also shown positive outcomes with CAZ/AVI in neonates. However, larger trials are needed to further investigate the safety and efficacy of CAZ/AVI in this population.

Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels

Clinical chemistry and laboratory medicine · 2022

📚 9 citations🎯 RCR 1.41🔓 Open Access

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Abstract Objectives The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the “gold standard” methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI. Methods Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7–10 days of life. Results Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions. Conclusions High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment.

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MME TINA HESSAMFAR-MOSTOUFIZADEH

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Top publications · les plus citées

Publications scientifiques (22) — classées par pathologie

Transversal5

Case report / série4

Épidémiologie & registres4

Revue générale3

Essai clinique2

Biothérapies non-anti-TNF1

Gériatrie1

IRM ostéo-articulaire1

Lupus1

Pédiatrie1

Revue / méta-analyse1

Santé mentale / fatigue1

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