Docteur PAULINE HENROT

Thèses universitaires

• Implication de CCN3 (NOV) dans la vasculopathie et la pigmentation cutanées de la Sclérodermie Systémique

  2018

  Implication of CCN3 (NOV) in vasculopathy and pigmentation of Systemic Sclerosis skin

  Biologie Cellulaire et Physiopathologie🎓 Bordeaux

  Direction : Muriel Cario-André

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

• Projet SCOOP : Rôle des cellules souches musculaires (cellules Satellites) dans le développement de la sarCOpénie associée à la BPCO

  Doctorant·e : Marie-Céline Littre

  Biologie Cellulaire et Physiopathologie🎓 Bordeaux

Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

• Access to respiratory rehabilitation in France: Opinions of pulmonologists and people with chronic obstructive pulmonary disease

  2025

  ArticleAnnals of Physical and Rehabilitation Medicine

• A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid

  2024

  ArticleEuropean Respiratory Journal

• Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers

  2024

  ArticleJournal of Allergy and Clinical Immunology: In Practice

• Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting

  2023

  ArticleInternational Journal of Molecular Sciences

• Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

  2022

  ArticleeLife

• Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models

  2022

  ArticleJournal of Cachexia, Sarcopenia and Muscle

• TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis

  2021

  ArticleAnnals of the Rheumatic Diseases

• Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience

  2021

  ArticleRespiratory Medicine

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

• HOPITAL HAUT-LEVEQUE - CHU

  Avenue DE MAGELLAN, 33604 Pessac

  ☎ 0556795679Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria

  Journal of immunology (Baltimore, Md. : 1950) · 2011

  📚 121 citations🎯 RCR 2.66Top 19% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor γt+ NK1.1− invariant NKT (iNKT) cells produce IL-17A independently of IL-6. In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR–CD1d interaction and partly relies on IL-23–mediated upregulation of IL-23R and IL-1R1 expression. We further show that IL-1 and IL-23 produced by pathogen-associated molecular pattern-stimulated dendritic cells induce this response from NK1.1− iNKT cells in vitro, involving mainly TLR2/4-signaling pathways. Finally, we found that IL-17A production by these cells occurs very early and transiently in vivo in response to heat-killed bacteria. Overall, our study indicates that peripheral lymph node NK1.1− iNKT cells could be a source of innate Th17-related cytokines during bacterial infections and supports the hypothesis that they are able to provide an efficient first line of defense against bacterial invasion.

• 2

  Chemokines in COPD: From Implication to Therapeutic Use

  International journal of molecular sciences · 2019

  📚 84 citations🎯 RCR 4.09Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death in the world. The underlying pathophysiological mechanisms have been the focus of extensive research in the past. The lung has a complex architecture, where structural cells interact continuously with immune cells that infiltrate into the pulmonary tissue. Both types of cells express chemokines and chemokine receptors, making them sensitive to modifications of concentration gradients. Cigarette smoke exposure and recurrent exacerbations, directly and indirectly, impact the expression of chemokines and chemokine receptors. Here, we provide an overview of the evidence regarding chemokines involvement in COPD, and we hypothesize that a dysregulation of this tightly regulated system is critical in COPD evolution, both at a stable state and during exacerbations. Targeting chemokines and chemokine receptors could be highly attractive as a mean to control both chronic inflammation and bronchial remodeling. We present a special focus on the CXCL8-CXCR1/2, CXCL9/10/11-CXCR3, CCL2-CCR2, and CXCL12-CXCR4 axes that seem particularly involved in the disease pathophysiology.

• 3

  Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting

  International journal of molecular sciences · 2023

  📚 59 citations🎯 RCR 10.26Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent respiratory disease mainly caused by tobacco smoke exposure. COPD is now considered as a systemic disease with several comorbidities. Among them, skeletal muscle dysfunction affects around 20% of COPD patients and is associated with higher morbidity and mortality. Although the histological alterations are well characterized, including myofiber atrophy, a decreased proportion of slow-twitch myofibers, and a decreased capillarization and oxidative phosphorylation capacity, the molecular basis for muscle atrophy is complex and remains partly unknown. Major difficulties lie in patient heterogeneity, accessing patients’ samples, and complex multifactorial process including extrinsic mechanisms, such as tobacco smoke or disuse, and intrinsic mechanisms, such as oxidative stress, hypoxia, or systemic inflammation. Muscle wasting is also a highly dynamic process whose investigation is hampered by the differential protein regulation according to the stage of atrophy. In this review, we report and discuss recent data regarding the molecular alterations in COPD leading to impaired muscle mass, including inflammation, hypoxia and hypercapnia, mitochondrial dysfunction, diverse metabolic changes such as oxidative and nitrosative stress and genetic and epigenetic modifications, all leading to an impaired anabolic/catabolic balance in the myocyte. We recapitulate data concerning skeletal muscle dysfunction obtained in the different rodent models of COPD. Finally, we propose several pathways that should be investigated in COPD skeletal muscle dysfunction in the future.

Publications scientifiques (29) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• Pulmonary rehabilitation after severe exacerbation of COPD: a nationwide population study

  Collection2024figshare

  Abstract Background Acute exacerbations of chronic obstructive pulmonary disease (COPD) lead to a significant reduction in quality of life and an increased mortality risk. Current guidelines strongly recommend pulmonary

• Optimization of human primary myoblasts culture from cryopreserved explants and adhesion on micropatterned soft substrates

  PeerReview2026FC3R - Groupement d’Intérêt Scientifique French Center 3R

  Skeletal muscle in vitro modelling requires appropriate biochemical and mechanical cues, which remains challenging to reproduce in standard 2D culture. Developing human-relevant models integrating extracellular matrix (E

• Pulmonary rehabilitation after severe exacerbation of COPD: a nationwide population study

  Collection2024figshare

  Abstract Background Acute exacerbations of chronic obstructive pulmonary disease (COPD) lead to a significant reduction in quality of life and an increased mortality risk. Current guidelines strongly recommend pulmonary

• A new tunable 3D alveolospheres model from human alveolar epithelial type 2 cells (AEC2) with reduced heterogeneity for studying cigarette smoke extract exposure

  Collection2026figshare

  Abstract Rationale Three-dimensional (3D) organoid models, such as alveolospheres, are unique tools for investigating the mechanisms underlying emphysema. However, high inter-organoid heterogeneity hampers consistent res

• A new tunable 3D alveolospheres model from human alveolar epithelial type 2 cells (AEC2) with reduced heterogeneity for studying cigarette smoke extract exposure

  Collection2026figshare

  Abstract Rationale Three-dimensional (3D) organoid models, such as alveolospheres, are unique tools for investigating the mechanisms underlying emphysema. However, high inter-organoid heterogeneity hampers consistent res

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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