📇 Rhumatologue · ST MALO CEDEX · (35) · Salarié

M VALENTIN HAS

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Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
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📍 ST MALO CEDEX (35)SalariéRPPS 10004428602

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Preoperative anxiety before anterior cruciate ligament reconstruction is a risk factor of post-operative pain

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026

📚 2 citations

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Abstract Purpose The study investigates whether preoperative anxiety, measured by the Surgical Fear Questionnaire (SFQ), influences post‐operative pain following anterior cruciate ligament (ACL) reconstruction. Methods A retrospective analysis of prospective data was performed, including 628 patients operated on for primary ACL reconstruction between October 2023 and July 2024. Patients were classified as low anxiety (SFQ < 30) and high anxiety (SFQ ≥ 30). Two groups were created for comparison and paired for age, sex and preoperative Lysholm score. The primary outcome was post‐operative pain evaluated by the visual analogue scale (VAS) at different intervals (Days 0–3). The secondary outcome measure was the percentage of patients who crossed the Patient Acceptable Symptom State (PASS) threshold for the VAS in both groups at the same points in time. Results A total of 628 patients were evaluated, and after one‐to‐one propensity score matching based on age, sex, and preoperative Lysholm score, 334 patients (167 in the low SFQ group and 167 in the high SFQ group) were included in the final analysis. The mean age was 31.6 (9.6) years. The VAS scores were significantly different between the two groups. The high anxiety group had a higher level of post‐operative pain at all time points (Day 0: p = 0.002; Day 1: p < 0.001; Day 2: p < 0.001; Day 3: p < 0.001). A significantly greater proportion ( p < 0.005) of patients in the low SFQ group crossed the PASS threshold compared to the high SFQ group at all times. The greatest difference was observed on Day 3 with 64.1% of the patients in the low SFQ group crossing the PASS threshold, compared to only 45.5% in the high SFQ group. Conclusions High preoperative anxiety is a risk factor for post‐operative pain following ACL reconstruction. These results highlight the importance of preoperative anxiety screening and targeted psychological support as part of prehabilitation protocols to reduce early post‐operative pain and potentially enhance recovery following ACL reconstruction. Study Design Cohort study. Level of Evidence Level III.

Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study)

Journal of internal medicine · 2026

📚 1 citations🔓 Open Access

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Abstract Objectives To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP‐ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD. Methods A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP‐ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months. Results In our study, 39% of patients had RP‐ILD at ILD diagnosis. Multivariate logistic regression analysis with cluster‐robust SE identified the factors associated with RP‐ILD at ILD diagnosis as male sex (aOR = 9.7 [1.6–59.5], p = 0.006), fever (aOR = 128 [12.6–1300], p < 0.001), organizing pneumonia (OP) pattern (aOR = 66.8 [3.4–1316], p = 0.006), and pleural effusion (aOR = 20.2 [1.1–373], p = 0.04), whereas RP‐ILD was associated with lower likelihood of severe muscle disease (aOR = 0.004 [0.0001–0.13], p = 0.002). Clustering analysis identified four distinct groups: Cluster 1 ( n = 62) included patients with systemic presentation, non‐RP‐ILD at ILD diagnosis, and anti‐Jo‐1 antibodies with good prognosis; Cluster 2 ( n = 40) included older age patients with more RP‐ILD at ILD diagnosis, pleuropericarditis, and a higher mortality rate. Conclusion Fever, pleural effusion, and OP pattern were independently associated with RP‐ILD in ASyS patients. Unsupervised cluster analysis identified a severe inflammatory phenotype in ASyS patients with ILD.

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M VALENTIN HAS

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Top publications · les plus citées

Publications scientifiques (30) — classées par pathologie

Transversal13

Épidémiologie & registres3

Essai clinique2

Microbiote2

Pharmacovigilance2

Revue générale2

Santé mentale / fatigue2

Vraie vie / RWE2

Génétique1

Pédiatrie1

Qualité de vie / PROMs1

Revue / méta-analyse1

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