📇 Rhumatologue · PERPIGNAN · (66) · Libéral
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Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
138.3 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR MICHEL GUARDIOLA
RESIDENCE DU POINT DU JOUR 83 CHEMIN DE LA POUDRIERE, 66000 PERPIGNAN
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📰 Actu.fr · 26/02/2026
<a href="https://news.google.com/rss/articles/CBMi3wFBVV95cUxQYUZfNi1aYVgxZUkwOGw0aVRSazFVcTJRR3hrTGRGeU5kSXhHZ0FFdTZQMWZJY3YzdXB6ZWVmV2hsbi1fdmVORDRHdWh0d3RqWWtGMDRJMy10V3N0UHhyNVF6NFp6RkZULVdZWlVBMjAwT2ZtNXhQanI0cklXS0ZDOVJ1OHNlTUhvNDNULWhjcm1wM0FlQVNrWkFxNWQ1Q3hqSFR5OEhTeVYzcWZpQ050ME10ZTd3VXZSYl
Atherosclerosis · 2012
The Journal of rheumatology · 2010
Objective.Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. Since the conventional lipid profile (total plasma cholesterol, triglycerides, low and high density lipoprotein cholesterol) is not consistently altered in SLE, we hypothesized that investigation of lipoprotein subclasses would improve prediction of risk of atherosclerosis in these patients.Methods.As a quantitative index of atherosclerosis, we measured the carotid intima-media thickness (IMT) in 68 patients with SLE and related the atherosclerosis to a detailed lipoprotein profile generated using nuclear magnetic resonance (NMR). We measured the cholesterol transported by the pool of remnant lipoproteins (RLPc) and evaluated the modulatory effect of the APOE genotype on the lipoprotein subclass profile and atherosclerosis associated with SLE.Results.Circulating lipoprotein remnant particles [RLPc and intermediate density lipoprotein (IDL)] were positively correlated with IMT, and among them, the indicator that explained 20.2% of the variability in carotid atherosclerosis measured in these patients was IDL, as assessed by NMR. Carriers of the APOE2 allele were at increased risk due to a significant accumulation of IDL particles.Conclusion.Lipoprotein subclasses are more associated with subclinical atherosclerosis in patients with SLE than the lipid variables that are routinely measured. The IDL fraction, which is significantly modulated by the APOE genotype, is the most strongly, significantly, and positively correlated with IMT.
International journal of rheumatic diseases · 2019
Abstract Aims Patients with systemic lupus erythematosus (SLE) suffer from accelerated atherosclerosis. Their most common cause of death is a cardiovascular disease (CVD), in spite of the presence of moderate lipid alterations and normal cardiovascular risk scores. However, cholesterol still accumulates in the arteries of SLE patients, so we aim to identify additional factors that may help explain the residual risk that exists in these patients. We focus on investigating whether the net charge contributes significantly to both the development and the progression of atherosclerosis in patients with SLE. Methods The lipoproteins from 78 patients with SLE and 32 controls were isolated via sequential ultracentrifugation. Lipoprotein subclasses distributions were analyzed via nuclear magnetic resonance spectroscopy and the net charges of very low‐density lipoprotein (VLDL), intermediate‐density lipoprotein (IDL), low‐density lipoprotein (LDL) and high‐density lipoprotein (HDL) were measured using a Zetasizer Nano‐ZS. The degree of atherosclerosis (carotid intima‐media thickness [cIMT]) was determined in all the participants. Results Each lipoprotein class exhibited a negative net charge. IDL and LDL net charge correlated negatively with cIMT ( r = −0.274, P = 0.034; r = −0.288; P = 0.033, respectively) in patients with SLE. This effect was independent of age, body mass index (BMI), gender, tobacco consumption, high‐sensitivity C‐reactive protein (hsCRP), lipid concentration and lipoprotein particle number. LDL net charge explained 4% of the cIMT variability among these patients; this contribution was also independent of age, BMI, gender, tobacco consumption, lipids levels, apolipoproteins and hsCRP. Conclusions Low‐density lipoprotein net charge may be considered a new independent contributor to subclinical atherosclerosis in SLE patients. The observed relationship was independent of lipid concentrations and extends the prominent role that IDL and LDL play in cardiovascular risk.
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Atherosclerosis · 2012 · Journal Article
Parra S, Vives G, Ferré R, González M, et al.
The Journal of rheumatology · 2010 · Journal Article
Gonzàlez M, Ribalta J, Vives G, Iftimie S, et al.
The Journal of rheumatology · 2010 · Journal Article
Gonzàlez M, Ribalta J, Vives G, Iftimie S, et al.
International journal of rheumatic diseases · 2019 · Journal Article
Rodríguez M, Guardiola M, Oliva I, Carles Vallvé J, et al.