📇 Rhumatologue · BRON CEDEX · (69) · Salarié

MME SIBYLLE GONZALEZ

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3 raisons identifiées

Plateau technique de référence
Hospices Civils de Lyon (HCL) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
39 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
144.6 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 BRON CEDEX (69)SalariéRPPS 10003062030

📊 Reconnaissance scientifique : 7/100📝 22 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Intestinal dysbiosis associated with systemic lupus erythematosus

mBio · 2014

📚 474 citations🎯 RCR 15.54Top 1% NIH🔓 Open Access

Lire l'abstract Crossref ↓

ABSTRACTSystemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody responses to nuclear and cytoplasmic antigens, including characteristic anti–double-stranded DNA antibodies. We performed a cross-sectional study in order to determine if an SLE-associated gut dysbiosis exists in patients without active disease. A group of 20 SLE patients in remission, for which there was strict inclusion and exclusion criteria, was recruited, and we used an optimized Ion Torrent 16S rRNA gene-based analysis protocol to decipher the fecal microbial profiles of these patients and compare them with those of 20 age- and sex-matched healthy control subjects. We found diversity to be comparable based on Shannon’s index. However, we saw a significantly lowerFirmicutes/Bacteroidetesratio in SLE individuals (median ratio, 1.97) than in healthy subjects (median ratio, 4.86;P< 0.002). A lowerFirmicutes/Bacteroidetesratio in SLE individuals was corroborated by quantitative PCR analysis. Notably, a decrease of someFirmicutesfamilies was also detected. This dysbiosis is reflected, based onin silicofunctional inference, in an overrepresentation of oxidative phosphorylation and glycan utilization pathways in SLE patient microbiota.IMPORTANCEGrowing evidence suggests that the gut microbiota might impact symptoms and progression of some autoimmune diseases. However, how and why this microbial community influences SLE remains to be elucidated. This is the first report describing an SLE-associated intestinal dysbiosis, and it contributes to the understanding of the interplay between the intestinal microbiota and the host in autoimmune disorders.

Guselkumab for the Treatment of Crohn's Disease: Induction Results From the Phase 2 GALAXI-1 Study

Gastroenterology · 2022

📚 166 citations🎯 RCR 15.64Top 1% NIH🩺 Clinique🔓 Open Access

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome

Autoimmunity reviews · 2021

📚 158 citations🎯 RCR 10.94Top 2% NIH

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MME SIBYLLE GONZALEZ

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (39) — classées par pathologie

Sjögren18

Transversal8

Lupus7

JAK inhibiteurs2

Anti-IL-231

Biomarqueurs / Auto-Ac1

Essai clinique1

Génétique1

Santé mentale / fatigue1

Sclérodermie1

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