📇 Rhumatologue · FREJUS · (83) · Libéral

M Francois-Xavier GONZALEZ

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3 raisons identifiées

Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
Expérience confirmée
25 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
118.8 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 FREJUS (83)LibéralRPPS 10003397337

Expérience confirmée

25ans d'exercice (thèse 2001)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Analyse d'image de la surface pulpaire de la canine mandibulaire : intérêts en odontologie légale
2001
Médecine. Anthropologie biologique🎓 Aix-Marseille 2

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling

Science (New York, N.Y.) · 2025

📚 79 citations🎯 RCR 28.69

Lire l'abstract Crossref ↓

Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid X receptor (FXR)—the receptor of GUDCA—alleviated osteoarthritis through intestine-secreted glucagon-like peptide 1 (GLP-1) in mice. GLP-1 receptor blockade attenuated these effects, whereas GLP-1 receptor activation mitigated osteoarthritis. Osteoarthritis patients exhibited a lower relative abundance of Clostridium bolteae , which promoted the formation of ursodeoxycholic acid (UDCA), a precursor of GUDCA. Treatment with C. bolteae and Food and Drug Administration–approved UDCA alleviated osteoarthritis through the gut FXR–joint GLP-1 axis in mice. UDCA use was associated with lower risk of osteoarthritis-related joint replacement in humans. These findings suggest that orchestrating the gut microbiota–GUDCA–intestinal FXR–GLP-1–joint pathway offers a potential strategy for osteoarthritis treatment.

MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers

International journal of molecular sciences · 2015

📚 32 citations🎯 RCR 1.08🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE.

Safety and efficacy comparison of three- vs four-needle technique in the management of moderate to severe osteoarthritis of the knee using cooled radiofrequency ablation

Skeletal radiology · 2021

📚 25 citations🎯 RCR 2.92Top 17% NIH

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M Francois-Xavier GONZALEZ

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (30) — classées par pathologie

Transversal17

Revue générale6

Essai clinique2

Revue / méta-analyse2

IRM ostéo-articulaire1

Lupus1

Ostéoporose1

Pharmacovigilance1

Sclérodermie1

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