Docteur Stéphane GIULIANI

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

• An unifing approach of LTI discrete-time state observers by means of complementary matrices

  1999

  ArticleIEEE Transactions on Automatic Control

• Détection et localisation de défaillances de capteurs dans un réseau de mesures pluviométriques : cas de l'agglomération nancéienne

  1998

  Thèse

• An application of Takagi-Sugeno modelling to an urban rainfall-runoff relationship

  1997

  CongrèsNorth American Fuzzy Information Processing Society, NAFIPS

• Rainfall-runoff modelling using a multi-model approach

  1997

  Congrès5th European Congress on Intelligent Techniques and Soft Computing

• Failure detection and isolation in a urban rain gauge network

  1996

  Congrès3rd International Workshop on Rainfall in Urban Areas

• Design of observer for descriptor systems

  1996

  ArticleInternational Journal of Systems Science

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

• HOPITAL ROBERT SCHUMAN DE VANTOUX -HPM

  Rue DU CHAMP MONTOY, 57070 Vantoux

  ☎ 0357842800Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation

  Blood advances · 2022

  📚 42 citations🎯 RCR 3.14Top 15% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Helios, encoded by IKZF2, is a member of the Ikaros family of transcription factors with pivotal roles in T-follicular helper, NK- and T-regulatory cell physiology. Somatic IKZF2 mutations are frequently found in lymphoid malignancies. Although germline mutations in IKZF1 and IKZF3 encoding Ikaros and Aiolos have recently been identified in patients with phenotypically similar immunodeficiency syndromes, the effect of germline mutations in IKZF2 on human hematopoiesis and immunity remains enigmatic. We identified germline IKZF2 mutations (one nonsense (p.R291X)- and 4 distinct missense variants) in six patients with systemic lupus erythematosus, immune thrombocytopenia or EBV-associated hemophagocytic lymphohistiocytosis. Patients exhibited hypogammaglobulinemia, decreased number of T-follicular helper and NK cells. Single-cell RNA sequencing of PBMCs from the patient carrying the R291X variant revealed upregulation of proinflammatory genes associated with T-cell receptor activation and T-cell exhaustion. Functional assays revealed the inability of HeliosR291X to homodimerize and bind target DNA as dimers. Moreover, proteomic analysis by proximity-dependent Biotin Identification revealed aberrant interaction of 3/5 Helios mutants with core components of the NuRD complex conveying HELIOS-mediated epigenetic and transcriptional dysregulation.

• 2

  Effect of Intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats

  The Journal of pharmacology and experimental therapeutics · 2009

  📚 27 citations
• 3

  Bradykinin and B₂ receptor antagonism in rat and human articular chondrocytes

  British journal of pharmacology · 2011

  📚 26 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  BACKGROUND AND PURPOSEIn osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage degradation. Here, we investigated effects of BK and its antagonists on chondrocytes, cells involved in cartilage homeostasis.EXPERIMENTAL APPROACHBK receptor density and affinities of BK, its analogues and antagonists were measured in cultured human and rat chondrocytes by radioligand binding. Effects of BK were assessed by accumulation of inositol phosphates (IP) and release of interleukin (IL)‐6 and IL‐8.KEY RESULTSDensity of [3H]‐BK binding sites was higher (13–30‐fold) and BK evoked a greater (48‐fold) IP production, in human than in rat chondrocytes. The BK B2 receptor antagonists MEN16132 and icatibant displayed similar binding affinity. MEN16132 was 40‐fold more potent than icatibant in the IP assay. In human chondrocytes, BK increased release (over 24 h) of IL‐6 and IL‐8, effects blocked by MEN16132 but not by the B1 receptor antagonist Lys‐[Leu8][desArg9]BK. BK‐induced release of IL‐6, but not of IL‐8, was partially inhibited by indomethacin (10 µM) and nordihydroguaiaretic acid (10 µM). Antagonists for the prostanoid EP receptors (AH6809 10 µM; L‐798 196, 200 nM; L‐161 982, 1 µM) were ineffective. Dexamethasone (100 nM) partially inhibited release of both IL‐6 and IL‐8. Inhibitors of intracellular downstream signalling pathways (SB203580 10 µM; PD98059, 30 µM; SP600125, 30 µM; BAY‐117085, 5 µM) indicated the involvement of p38 MAPK and the activation of NF‐κB.CONCLUSION AND IMPLICATIONSBK mediated inflammatory changes and cartilage degradation and B2 receptor blockade would, therefore, be a potential treatment for OA.

Publications scientifiques (10) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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