Docteur BERNARD GILQUIN
Diplômes
🎓 DES & spécialité ordinale
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Direction de thèses
🎓 6 thèses dirigéesModélisation du complexe récepteur muscarinique-toxine MT7 à partir de données thermodynamiques
2008Doctorant·e : Guillaume Letellier
Analyse de génomes et modélisation moléculaire🎓 Paris 7Etude structurale et fonctionnelle de la protéine KIN17 humaine
2008Doctorant·e : Albane Le Maire-Coirier
Biologie structurale🎓 Paris 6Analyse structurale de protéines de l'enveloppe nucléaire impliquées dans des pathologies génétiques
2006Doctorant·e : Sandrine Caputo
Biologie structurale🎓 Paris 6Etude structurale et fonctionnelle de deux protéines des voies de surveillance du génome : 53BP1 humain et RAD9 de levure
2005Doctorant·e : Gaëlle Charier
Sciences biologiques🎓 Paris 11Etudes par radiocristallographie de l'interaction entre les superantigènes des cellules B et la région Fab des récepteurs des lymphocytes B
2002Doctorant·e : Marc Graille
Biologie🎓 Paris 11Etude structurale et dynamique de l'oxydoreductase de dithiol-disulfure dsba d'escherichia coli
2001Doctorant·e : JOEL COUPRIE
Sciences biologiques fondamentales et appliquées🎓 Paris 11
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
33
h articles cités ≥ h fois chacun. Un h de 33 = 33 publications avec 33+ citations.
Citations
4 101
Publications
118
i10-index
62
Thématiques principales
- Ion channel regulation and function ×22
- Venomous Animal Envenomation and Studies ×20
- RNA Research and Splicing ×14
- Protein Structure and Dynamics ×11
- RNA and protein synthesis mechanisms ×11
Affiliations FR : Centre National de la Recherche Scientifique · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Université Paris-Saclay
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid
2017ArticleScientific Reports
Erratum: High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid
2017ArticleScientific Reports
Bacteriophage SPP1 tail tube protein self-assembles into β-structure-rich tubes.
2015ArticleJournal of Biological Chemistry
Molecular exploration of the $\alpha_{1A}$-adrenoceptor orthosteric site: Binding site definition for epinephrine, HEAT and prazosin
2014ArticleFEBS Letters
Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain
2014ArticleFEBS Journal
New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba
2013ArticleToxicon
Orthosteric Binding of ρ-Da1a, a Natural Peptide of Snake Venom Interacting Selectively with the α1A-Adrenoceptor
2013ArticlePLoS ONE
Structure of the MutL$\alpha$ C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
2013ArticleNature Structural and Molecular Biology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Articles de presse (2)
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
- Le Pr Stéphane Oustric élu président du Conseil national de l'Ordre des médecins - Egora
📰 Egora · 25/06/2025
<a href="https://news.google.com/rss/articles/CBMiugFBVV95cUxQOWpqcWtrR3U4UXNmd0RSMWxKR3VHVkVnRkY4bWxzNEQ2Z05FRGpVaTlBZnhMQkZLMkx4S3pmRkljS2dxZDJSaFE4VUNJX1NNOGRCRGhFWWd0V0ZrOFlVVjdGTXFOZFQ2NjFOcEZ1dmM2SnJta3ZucjlRQ0lUZ3g3Q0JNSi1lcTZkSE11TFhoaHp3SDRBT2JOeGpXenlBWVF6bW8wdWx1QUk5bzZQT3ZWVmpYYW5kMFo5Q2
- Bientôt la fin des avis Google sur les soignants ? : "On y travaille avec le ministère" confie l'Ordre des médecins - Egora
📰 Egora · 02/10/2025
<a href="https://news.google.com/rss/articles/CBMivAFBVV95cUxNXzJhclM5UmZoREhScW03MjFoRHhGaGstV2tDck5NNnFIN0lHdDRTZktpQnE2MWN3eld4dVhsd3RCb25QS0lvaXA3ckIyVmVBVE1IX1NlM3E1QUM1V1ZfNXptbExaYkVDTHpwYnBFSW5Nc043Z1pGSjFBWHlManZMV1JQcE1Kei1DTWJqenUwelAwUVJULXpVaDNnTUhzTEdkMTYtWlRSZVFfQ2ZWUG9mdDR2RG5IaFM4d2
Top publications · les plus citées
- 1The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy
Structure (London, England : 1993) · 2002
📚 231 citations🎯 RCR 3.99Top 11% NIH - 2Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
The EMBO journal · 2005
📚 204 citations🎯 RCR 4.63Top 9% NIH - 3Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating
Proceedings of the National Academy of Sciences of the United States of America · 2009
Lire l'abstract Crossref ↓
In many bacterial viruses and in certain animal viruses, the double-stranded DNA genome enters and exits the capsid through a portal gatekeeper. We report a pseudoatomic structure of a complete portal system. The bacteriophage SPP1 gatekeeper is composed of dodecamers of the portal protein gp6, the adaptor gp15, and the stopper gp16. The solution structures of gp15 and gp16 were determined by NMR. They were then docked together with the X-ray structure of gp6 into the electron density of the ≈1-MDa SPP1 portal complex purified from DNA-filled capsids. The resulting structure reveals that gatekeeper assembly is accompanied by a large rearrangement of the gp15 structure and by folding of a flexible loop of gp16 to form an intersubunit parallel β-sheet that closes the portal channel. This stopper system prevents release of packaged DNA. Disulfide cross-linking between β-strands of the stopper blocks the key conformational changes that control genome ejection from the virus at the beginning of host infection.
Publications scientifiques (32) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal32
▼
Transversal32
▼- High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid
Scientific reports · 2017 · Journal Article
Vernhes E, Renouard M, Gilquin B, Cuniasse P, et al.
📚 21 cit. - Bacteriophage SPP1 tail tube protein self-assembles into β-structure-rich tubes
The Journal of biological chemistry · 2015 · Journal Article
Langlois C, Ramboarina S, Cukkemane A, Auzat I, et al.
📚 24 cit. - Molecular exploration of the α(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin
FEBS letters · 2014 · Journal Article
Maïga A, Dupont M, Blanchet G, Marcon E, et al.
📚 7 cit. - Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain
The FEBS journal · 2014 · Journal Article
Maisonneuve P, Caillet-Saguy C, Raynal B, Gilquin B, et al.
📚 20 cit. - New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba
Toxicon : official journal of the International Society on Toxinology · 2013 · Journal Article
Blanchet G, Upert G, Mourier G, Gilquin B, et al.
📚 13 cit. - Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor
PloS one · 2013 · Journal Article
Maïga A, Merlin J, Marcon E, Rouget C, et al.
📚 10 cit. - Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A
Science signaling · 2013 · Journal Article
Bourgeois B, Gilquin B, Tellier-Lebègue C, Östlund C, et al.
📚 45 cit.🎯 RCR 1.15 - Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site
Nature structural & molecular biology · 2013 · Journal Article
Gueneau E, Dherin C, Legrand P, Tellier-Lebegue C, et al.
📚 100 cit.🎯 RCR 2.46 - [Internal medicine and Third Reich: a past that does not pass]
Presse medicale (Paris, France : 1983) · 2012 · Historical Article
Gilquin B
- Solution structure of gp17 from the Siphoviridae bacteriophage SPP1: insights into its role in virion assembly
Proteins · 2012 · Journal Article
Chagot B, Auzat I, Gallopin M, Petitpas I, et al.
📚 16 cit. - Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor
The Journal of biological chemistry · 2011 · Journal Article
Marquer C, Fruchart-Gaillard C, Letellier G, Marcon E, et al.
📚 34 cit.🎯 RCR 1.06 - Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane
Biochemistry · 2010 · Journal Article
Kondé E, Bourgeois B, Tellier-Lebegue C, Wu W, et al.
📚 27 cit. - Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating
Proceedings of the National Academy of Sciences of the United States of America · 2009 · Journal Article
Lhuillier S, Gallopin M, Gilquin B, Brasilès S, et al.
📚 108 cit.🎯 RCR 2.71 - Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Molecular and cellular biology · 2009 · Journal Article
Dherin C, Gueneau E, Francin M, Nunez M, et al.
📚 55 cit.🎯 RCR 1.02 - Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA
Biochemistry · 2008 · Journal Article
Laguri C, Duband-Goulet I, Friedrich N, Axt M, et al.
📚 44 cit. - Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain
Protein science : a publication of the Protein Society · 2007 · Journal Article
Carlier L, Couprie J, le Maire A, Guilhaudis L, et al.
📚 11 cit. - The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA
Nucleic acids research · 2007 · Journal Article
Lancelot N, Charier G, Couprie J, Duband-Goulet I, et al.
📚 24 cit. - The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain
The Journal of biological chemistry · 2006 · Journal Article
Caputo S, Couprie J, Duband-Goulet I, Kondé E, et al.
📚 53 cit. - NMR assignment of region 51-160 of human KIN17, a DNA and RNA-binding protein
Journal of biomolecular NMR · 2006 · Letter
Carlier L, le Maire A, Braud S, Masson C, et al.
📚 3 cit. - NMR assignment of region 655-775 of human MAN1
Journal of biomolecular NMR · 2006 · Letter
Caputo S, Lin F, Gilquin B, Worman HJ, et al.
📚 1 cit. - A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions
The Journal of biological chemistry · 2005 · Journal Article
Gilquin B, Braud S, Eriksson MA, Roux B, et al.
📚 43 cit.🎯 RCR 1.02 - Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteins
Protein science : a publication of the Protein Society · 2005 · Comparative Study
Alpha-Bazin B, Lorphelin A, Nozerand N, Charier G, et al.
📚 9 cit. - Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
The EMBO journal · 2005 · Journal Article
Llinas P, Le Du MH, Gårdsvoll H, Danø K, et al.
📚 204 cit.🎯 RCR 4.63🔬→🩺 Translationnel - The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding
Structure (London, England : 1993) · 2004 · Journal Article
Charier G, Couprie J, Alpha-Bazin B, Meyer V, et al.
📚 88 cit.🎯 RCR 1.33 - Comparison of sea anemone and scorpion toxins binding to Kv1 channels: an example of convergent evolution
Toxicon : official journal of the International Society on Toxinology · 2004 · Comparative Study
Gasparini S, Gilquin B, Ménez A
📚 19 cit. - Motions and structural variability within toxins: implication for their use as scaffolds for protein engineering
Protein science : a publication of the Protein Society · 2003 · Comparative Study
Gilquin B, Bourgoin M, Ménez R, Le Du MH, et al.
📚 20 cit. - Solution NMR structure and backbone dynamics of the PsaE subunit of photosystem I from Synechocystis sp. PCC 6803
Biochemistry · 2002 · Journal Article
Barth P, Savarin P, Gilquin B, Lagoutte B, et al.
📚 10 cit. - Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers
The Journal of biological chemistry · 2002 · Journal Article
Gilquin B, Racapé J, Wrisch A, Visan V, et al.
📚 58 cit.🎯 RCR 1.33 - The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy
Structure (London, England : 1993) · 2002 · Journal Article
Krimm I, Ostlund C, Gilquin B, Couprie J, et al.
📚 231 cit.🎯 RCR 3.99 - Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor
Proceedings of the National Academy of Sciences of the United States of America · 2002 · Journal Article
Fruchart-Gaillard C, Gilquin B, Antil-Delbeke S, Le Novère N, et al.
📚 106 cit.🎯 RCR 2.58 - Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase
Structure (London, England : 1993) · 2002 · Journal Article
Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, et al.
📚 13 cit. - Influence of accompanying anion on intestinal radiocalcium absorption
Calcified tissue international · 1987 · Clinical Trial
Marchandise X, Pagniez D, Ythier H, Gilquin B, et al.
📚 12 cit.🎯 RCR 1.01🩺 Clinique
Datasets & protocoles partagés
1H, 13C and 15N NMR assignment of the region 51-160 of human KIN17 protein
Dataset2006Biological Magnetic Resonance Bankgp16
Dataset2009Biological Magnetic Resonance BankNMR structure of protein gp15 of bacteriophage SPP1
Dataset2009Biological Magnetic Resonance BankStructure of bacteriophage SPP1 gp17 protein
Dataset2012Biological Magnetic Resonance Bank1H, 13C and 15N NMR assignment of the region 1463-1617 of mouse p53 Binding Protein 1 (53BP1)
Dataset2004Biological Magnetic Resonance BankStructure and dynamics of the anticodon-arm binding domain of Bacillus stearothermophilus tyrosyl-tRNA synthetase
Dataset2002Biological Magnetic Resonance Bank
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).