📇 Rhumatologue · NANCY CEDEX · (54) · Hospitalier

MME Solenn GEORGE

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Auteur de référence en rhumatologie
40 articles scientifiques publiés — un praticien à la pointe de la recherche
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146.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 NANCY CEDEX (54)HospitalierRPPS 10102168738

✨ Génération du profil synthétique IA en cours…

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CHRU NANCY - HOPITAL CENTRAL
29 AV DE LATTRE DE TASSIGNY CO 60034, 54035 NANCY CEDEX
☎ 0383858585Activité de soin et de pharmacie

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Top publications · les plus citées

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

The Lancet. Rheumatology · 2021

📚 347 citations🎯 RCR 34.05Top 0% NIH🔓 Open Access📄 PDF gratuit ↗

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review

Medicine and science in sports and exercise · 2019

📚 162 citations🎯 RCR 11.63Top 2% NIH🔓 Open Access

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ABSTRACT Introduction We conducted a systematic umbrella review to evaluate the literature relating to effects of physical activity on pain, physical function, health-related quality of life, comorbid conditions and osteoarthritis (OA) structural disease progression in individuals with lower-extremity OA. Methods Our primary search encompassed 2011 to February 2018 for existing systematic reviews (SR), meta-analyses (MA) and pooled analyses dealing with physical activity including exercise (not mixed with any other intervention and compared to a no-activity control group). A supplementary search encompassed 2006 to February 2018 for original research related to physical activity (including exercise) and lower limb OA progression. Study characteristics were abstracted, and risk of bias was assessed. Results Physical activity decreased pain and improved physical function (strong evidence) and improved health-related quality of life (moderate evidence) among people with hip or knee OA relative to less active adults with OA. There was no evidence to suggest accelerated OA progression for physical activity below 10,000 steps per day. Both physical activity equivalent to the 2008 Physical Activity Guidelines for Americans (150 min·wk−1 of moderate-intensity exercise in bouts ≥10 min) and lower levels of physical activity (at least 45 total minutes per week of moderate-intensity) were associated with improved or sustained high function. No SR/MA addressing comorbid conditions in OA were found. Measurable benefits of physical activity appeared to persist for periods of up to 6 months following cessation of a defined program. Conclusions People with lower-extremity OA should be encouraged to engage in achievable amounts of physical activity, of even modest intensities. They can choose to accrue minutes of physical activity throughout the entire day, irrespective of bout duration, and be confident in gaining some health and arthritis-related benefits.

Future directions in painful knee osteoarthritis: harnessing complexity in a heterogeneous population

Physical therapy · 2014

📚 54 citations🎯 RCR 2.65Top 19% NIH🔓 Open Access📄 PDF gratuit ↗

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This perspective article proposes a conceptual model for the pain experience for individuals diagnosed with knee osteoarthritis (OA). Pain in knee OA is likely a heterogeneous, multifactorial phenomenon that involves not only the OA disease process but also elements specific to patient psychology and pain neurophysiology. The relevant contributions to the pain experience for any individual patient remain difficult, if not impossible, to definitively determine, and the rationale for many clinical treatment decisions arises primarily from a mechanistic understanding of OA pathophysiology. The Osteoarthritis Research Society International (OARSI) recently identified “phenotyping” of OA pain as a research priority to “better target pain therapies to individual patients.” This perspective article proposes that contributions from 3 domains—knee pathology, psychological distress, and pain neurophysiology—should be considered equally important in future efforts to understand pain phenotypes in knee OA. Ultimately, characterization of pain phenotypes may aid in the understanding of the pain experience and the development of interventions specific to pain for individual patients.

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MME Solenn GEORGE

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Top publications · les plus citées

Publications scientifiques (40) — classées par pathologie

Transversal14

Épidémiologie & registres8

Activité physique / Rééducation4

Lombalgie3

Qualité de vie / PROMs3

Revue générale3

Revue / méta-analyse2

Anti-IL-171

Corticothérapie1

Économie santé1

Essai clinique1

Lupus1

Pédiatrie1

Pharmacovigilance1

Santé mentale / fatigue1

Sjögren1

Vraie vie / RWE1

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