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Rhumatologue

Docteur THOMAS FUNCK-BRENTANO

📍 Paris 12e Arrondissement (75)HospitalierRPPS 10100382604
📊 Reconnaissance scientifique : 25/100📝 125 articles publiés📚 HAL (8)

Diplômes

🎓 DES & spécialité ordinale

  • DES Rhumatologie
  • Rhumatologie (SM)

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

25

h articles cités ≥ h fois chacun. Un h de 25 = 25 publications avec 25+ citations.

Citations

2 403

Publications

125

i10-index

38

Thématiques principales

  • Bone health and osteoporosis research ×40
  • Bone Metabolism and Diseases ×30
  • Osteoarthritis Treatment and Mechanisms ×24
  • Bone health and treatments ×22
  • Parathyroid Disorders and Treatments ×14

Affiliations FR : Inserm · Université Paris Cité · Sorbonne Paris Cité

Voir sur OpenAlex ↗🆔 ORCID 0000-0001-7684-2405

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

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Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

  • 1
    Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

    Annals of the rheumatic diseases · 2017

    📚 289 citations🎯 RCR 12.51Top 2% NIH
  • 2
    Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank

    Arthritis & rheumatology (Hoboken, N.J.) · 2019

    📚 162 citations🎯 RCR 9.11Top 3% NIH🔓 Open Access📄 PDF gratuit ↗
    Lire l'abstract Crossref ↓

    ObjectiveThere is no curative treatment for osteoarthritis (OA), which is the most common form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and hand OA.MethodsIndividual‐level data from 384,838 unrelated participants in the UK Biobank study were analyzed. Mendelian randomization (MR) analyses were performed to test for causality for body mass index (BMI), bone mineral density (BMD), serum high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, and triglyceride levels, type 2 diabetes, systolic blood pressure (BP), and C‐reactive protein (CRP) levels. The primary outcome measure was OA determined using hospital diagnoses (all sites, n = 48,431; knee, n = 19,727; hip, n = 11,875; hand, n = 2,330). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.ResultsMR analyses demonstrated a robust causal association of genetically determined BMI with all OA (OR per SD increase 1.57 [95% CI 1.44–1.71]), and with knee OA and hip OA, but not with hand OA. Increased genetically determined femoral neck BMD was causally associated with all OA (OR per SD increase 1.14 [95% CI 1.06–1.22]), knee OA, and hip OA. Low systolic BP was causally associated with all OA (OR per SD decrease 1.55 [95% CI 1.29–1.87]), knee OA, and hip OA. There was no evidence of causality for the other tested metabolic factors or CRP level.ConclusionOur findings indicate that BMI exerts a major causal effect on the risk of OA at weight‐bearing joints, but not at the hand. Evidence of causality of all OA, knee OA, and hip OA was also observed for high femoral neck BMD and low systolic BP. However, we found no evidence of causality for other metabolic factors or CRP level.

  • 3
    Dkk-1-mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis in mice

    Arthritis & rheumatology (Hoboken, N.J.) · 2014

    📚 106 citations🎯 RCR 3.84Top 11% NIH
    Lire l'abstract Crossref ↓

    ObjectiveWnt signaling is a master regulator of joint homeostasis, but its role in osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation of Wnt/β‐catenin in knee joints of mice with OA and to assess how inhibiting this pathway in bone could affect cartilage.MethodsOA was induced by partial meniscectomy in Topgal mice and in transgenic mice overexpressing Dkk‐1 under the control of the 2.3‐kb Col1a1 promoter (Col1a1‐Dkk‐1–Tg mice). Wnt/β‐catenin activation was assessed by X‐Gal staining at baseline and at weeks 4, 6, and 9. Cartilage and bone damage was analyzed in Col1a1‐Dkk‐1–Tg mice with OA at week 6. Primary chondrocytes and cartilage explants were used to assess the effect of Dkk‐1 on cartilage catabolism.ResultsIn meniscectomized Topgal mice, Wnt was mainly activated in osteocytes from the subchondral bone at week 6 after OA induction, as well as in osteophytes and synovium at week 4. Chondrocytes from damaged zones expressed X‐Gal from week 4. Dkk‐1 expression was high in chondrocytes in control mouse knees (mean ± SEM 84.2 ± 3.1%) but decreased greatly in knees of meniscectomized mice from week 4 (mean ± SEM 14.4 ± 3.8%). The OA score was lower in meniscectomized Col1a1‐Dkk‐1–Tg mice at week 6 compared with wild‐type mice (5.1 ± 0.6 versus 8.4 ± 0.6; P = 0.002). Subchondral bone fraction and osteophyte volume were decreased. However, cartilage explants from Col1a1‐Dkk‐1–Tg mice showed proteoglycan loss and increased NITEGE expression. Expression of vascular endothelial growth factor (VEGF) was reduced in osteoblasts from Col1a1‐Dkk‐1–Tg mice, thereby decreasing expression of messenger RNA for matrix metalloproteinases in chondrocytes.ConclusionWnt activation in OA affects the whole joint, particularly bone. Selective inhibition of this pathway in bone by Dkk‐1 decreased OA severity through VEGF inhibition.

Publications scientifiques (50) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal39

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Génétique4

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Revue générale3

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Essai clinique2

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Échographie1

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Pédiatrie1

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Datasets & protocoles partagés

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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