📇 Rhumatologue · CHAMBERY · (73) · Libéral

MME ANNABELLE FAYE

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27 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 CHAMBERY (73)LibéralRPPS 10100165512

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR ANNABELLE FAYE
BRICKHOUSE SCM SOS MEDECINS CHAMBERY 91 RUE PHILIBERT ROUTIN, 73000 CHAMBERY
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CABINET DU DR ANNABELLE FAYE
SCM SOS MEDECINS 73 560 BOULEVARD LEPIC, 73100 AIX LES BAINS
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Top publications · les plus citées

Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis

The Lancet. Child & adolescent health · 2020

📚 117 citations🎯 RCR 6.44Top 5% NIH🔓 Open Access📄 PDF gratuit ↗

Registries in rheumatological and musculoskeletal conditions. Paediatric Behçet's disease: an international cohort study of 110 patients. One-year follow-up data

Rheumatology (Oxford, England) · 2011

📚 50 citations🎯 RCR 1.89🔓 Open Access📄 PDF gratuit ↗

Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling

Rheumatology (Oxford, England) · 2020

📚 33 citations🎯 RCR 2.18Top 24% NIH🔓 Open Access

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Abstract Objectives JDM and juvenile overlap myositis represent heterogeneous subtypes of juvenile idiopathic inflammatory myopathy (JIIM). Chronic evolution can occur in up to 60% of cases, and morbidity/mortality is substantial. We aimed to describe the clinical, biological, histological and type I IFN status in JIIM associated with anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies at presentation (group 1) in comparison with other JIIM (group 2). Methods This was a retrospective and prospective study of patients with JIIM ascertained from three French paediatric rheumatology reference centres between 2013 and 2019. Muscle biopsies were reviewed. Type I interferon pathway activity was assessed by dosage of IFNα serum protein and the expression of IFN-stimulated genes. Results Sixty-four patients were included, 13 in group 1 (54% JDM and 46% juvenile overlap myositis) and 51 in group 2 (76% JDM and 24% juvenile overlap myositis). Group 1 patients demonstrated more arthritis, skin ulcerations, lupus features and interstitial lung disease, and a milder muscular involvement. Serum IFNα levels were higher in group 1 than 2, and decreased after treatment or improvement in both groups. Outcome was similar in both groups. Unconventional treatment (more than two lines) was required in order to achieve remission, especially when skin ulceration was reported. Conclusion This study indicates a higher frequency of arthritis, skin ulcerations and interstitial lung disease, but milder muscular involvement, in JIIM with positive anti-MDA5 autoantibodies compared with other JIIM. Our data support an important role of systemic IFNα in disease pathology, particularly in the anti-MDA5 auto-antibody-positive subgroup. In severe and refractory forms of JIIM, IFNα may represent a therapeutic target.

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MME ANNABELLE FAYE

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Top publications · les plus citées

Publications scientifiques (27) — classées par pathologie

Pédiatrie14

Arthrite juvénile4

Transversal3

Lupus2

Pharmacovigilance1

Revue / méta-analyse1

Revue générale1

Sjögren1

Vascularites des gros vaisseaux1

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