📇 Rhumatologue · ANTONY · (92) · Libéral
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2 raisons identifiées
Praticien-chercheur
7 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
136 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR JEAN-FRANCOIS DOUCET
17 AVENUE DU PARC DE SCEAUX, 92160 ANTONY
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Craniomaxillofacial trauma & reconstruction · 2011
Systemic sclerosis (SSc) is a multisystem connective tissue disease of unknown etiology. The hallmark of SSc is scleroderma, referring to the presence of thickened, hardened skin. Oral and maxillofacial manifestations of the disease are numerous including masklike appearance, trismus, muscular atrophy, thin atrophied lips, secondary microstomia, xerostomia, rigidity of tongue and lips, widening of the periodontal ligament space, trigeminal neuralgia, and resorption of the mandible. A 35-year-old woman with limited cutaneous SSc presented with bilateral mandibular condylysis, severe class II mandibular deficiency, and large anterior open bite and limited range of mandibular opening at 27 mm. Surgical correction consisted of bilateral total temporomandibular joint reconstruction with stock prostheses combined with Le Fort I maxillary impaction and functional advancement genioplasty. This resulted in a functional occlusion with elimination of her open bite and a more esthetic profile. Her occlusion has remained stable at 7 months. The incidence of mandibular resorption in SSc has been found to be 20% to 33%. The mandibular angles are most commonly involved (37.6%), followed by the condyle (20.8%), coronoid process (20.0%), and the posterior border of the ascending ramus (14.4%). Bilateral condylysis is present in 13.7% of the cases. Very few cases of surgical correction of malocclusion induced by SSc-related condylysis have been reported in the literature. To the best of our knowledge, this is the first case report of bilateral condylysis from SSc where surgical replacement of the resorbed condyles was attempted. Bilateral total temporomandibular joint replacement can give these patients a functional occlusion, improved facial balance, and improved quality of life.
Chemical biology & drug design · 2018
Given the hepatotoxicity and an unfavorable pharmacokinetic profile of zileuton (Zyflo®), currently the only approved and clinically used 5‐Lipoxygenase (5‐LO) inhibitor, the search for potent and safe 5‐LO inhibitors is highly demanded. The action of several phenolic acid phenethyl esters as potential 5‐Lipoxygenase (5‐LO) inhibitors has been investigated. For this purpose, a series of 14 phenethyl esters was synthesized and their impact on 5‐LO inhibition was evaluated. The effects of position and number of hydroxyl and methoxy groups on the phenolic acid were investigated. The shortening of the linker between the carbonyl and the catechol moiety as well as the presence of the α,β‐unsaturated carbonyl group was also explored. The sinapic acid phenethyl ester (10), which can be named SAPE (10) by analogy to caffeic acid phenethyl ester (CAPE), inhibited 5‐LO in a concentration‐dependent manner and outperformed both zileuton (1) and CAPE (2). With an IC50 of 0.3 μm, SAPE (10) was threefold more potent than CAPE (2) and 10‐fold more potent than zileuton (1), the only 5‐LO inhibitor approved for clinical use. Unlike CAPE (2), SAPE (10) had no effect on 12‐lipoxygenase (12‐LO) and less effect on cyclooxygenase 1 (COX‐1) which makes it a more selective 5‐LO inhibitor.
Animals : an open access journal from MDPI · 2023
Biomarkers for osteoarthritis (OA) in horses have been extensively investigated, but translation into clinical use has been limited due to cost, limited sensitivity, and practicality. Identifying novel biomarkers that overcome these limitations could facilitate early diagnosis and therapy. This study aimed to compare the concentrations of synovial fluid (SF) and plasma cell-free DNA (cfDNA) over time in control horses with those with induced carpal OA. Following an established model, unilateral carpal OA was induced in 9 of 17 healthy Thoroughbred fillies, while the remainder were sham-operated controls. Synovial fluid and plasma samples were obtained before induction of OA (Day 0) and weekly thereafter until Day 63, and cfDNA concentrations were determined using fluorometry. The SF cfDNA concentrations were significantly higher for OA joints than for sham-operated joints on Days 28 (median 1430 μg/L and 631 μg/L, respectively, p = 0.017) and 63 (median 1537 μg/L and 606 μg/L, respectively, p = 0.021). There were no significant differences in plasma cfDNA between the OA and the sham groups after induction of carpal OA. Plasma cfDNA measurement is not sufficiently sensitive for diagnostic purposes in this induced model of OA. Synovial fluid cfDNA measurement may be used as a biomarker to monitor early disease progression in horses with OA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Animals : an open access journal from MDPI · 2023 · Journal Article
Panizzi L, Dittmer KE, Vignes M, Doucet JS, et al.
Chemical biology & drug design · 2018 · Journal Article
Touaibia M, Hébert MJG, Levesque NA, Doiron JA, et al.
La Revue de medecine interne · 2005 · Case Reports
Kurtz B, Hauss PA, Druesne L, Chassagne P, et al.
La Revue de medecine interne · 2003 · Case Reports
Druesne L, Verdonck A, Derambure V, Kadri K, et al.
Craniomaxillofacial trauma & reconstruction · 2011 · Journal Article
Doucet JC, Morrison AD
La Revue de medecine interne · 2008 · Journal Article
Doucet J
European journal of case reports in internal medicine · 2019 · Case Reports
Bensiradj F, Hignard M, Nakkash R, Proux A, et al.