📇 Rhumatologue · FORT DE FRANCE CEDEX · (972) · Hospitalier

MME Aïssatou DIALLO

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3 raisons identifiées

Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
106.4 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 FORT DE FRANCE CEDEX (972)HospitalierRPPS 10111907639

Publications actives

6ans d'exercice (thèse 2020)·8 publications sur 5 ans

📊 Reconnaissance scientifique : 12/100📝 24 articles publiés🇫🇷 Publications académiques françaises (2)

✨ Génération du profil synthétique IA en cours…

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis

The Journal of infectious diseases · 2021

📚 148 citations🎯 RCR 8.37Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Background Coronavirus disease 2019 (COVID-19) clinical expression is pleiomorphic, severity is related to age and comorbidities such as diabetes and hypertension, and pathophysiology involves aberrant immune activation and lymphopenia. We wondered if the myeloid compartment was affected during COVID-19 and if monocytes and macrophages could be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods Monocytes and monocyte-derived macrophages (MDMs) from COVID-19 patients and controls were infected with SARS-CoV-2 and extensively investigated with immunofluorescence, viral RNA extraction and quantification, and total RNA extraction followed by reverse-transcription quantitative polymerase chain reaction using specific primers, supernatant cytokines (interleukins 6, 10, and 1β; interferon-β; transforming growth factor–β1, and tumor necrosis factor–α), and flow cytometry. The effect of M1- vs M2-type or no polarization prior to infection was assessed. Results SARS-CoV-2 efficiently infected monocytes and MDMs, but their infection is abortive. Infection was associated with immunoregulatory cytokines secretion and the induction of a macrophagic specific transcriptional program characterized by the upregulation of M2-type molecules. In vitro polarization did not account for permissivity to SARS-CoV-2, since M1- and M2-type MDMs were similarly infected. In COVID-19 patients, monocytes exhibited lower counts affecting all subsets, decreased expression of HLA-DR, and increased expression of CD163, irrespective of severity. Conclusions SARS-CoV-2 drives monocytes and macrophages to induce host immunoparalysis for the benefit of COVID-19 progression. SARS-CoV-2 infection of macrophages induces a specific M2 transcriptional program. In Covid-19 patients, monocyte subsets were decreased associated with up-expression of the immunoregulatory molecule CD163 suggesting that SARS-CoV-2 drives immune system for the benefit of Covid-19 disease progression.

Ectopic Germinal Center-Like Structures in Minor Salivary Gland Biopsy Tissue Predict Lymphoma Occurrence in Patients With Primary Sjögren's Syndrome

Arthritis & rheumatology (Hoboken, N.J.) · 2018

📚 57 citations🎯 RCR 2.58Top 20% NIH

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ObjectiveTo determine risk factors for primary Sjögren's syndrome (SS)–associated lymphoma in a multicenter cohort of patients, with analysis of the predictive power of previously reported risk factors, including the presence of ectopic germinal center (GC)–like structures in minor salivary gland (MSG) biopsy tissue.MethodsOne hundred fifteen patients with primary SS were included, and MSG biopsy tissue from these patients was retrospectively examined, focusing on the presence of ectopic GC‐like structures. Epidemiologic, clinical, biologic, immunologic, and histologic data were collected at the time of diagnosis of primary SS. Patients with non‐Hodgkin's lymphoma (NHL) were compared with those without NHL during the follow‐up period, using a Cox proportional hazards multiple regression model.ResultsNHL was diagnosed in 8 patients (6.96%), and ectopic GC‐like structures in 19 patients (16.5%). The presence of ectopic GC‐like structures was associated with a 7.8‐fold increased risk of lymphoma occurrence (95% confidence interval [95% CI] 1.73–34.86 [P = 0.0075]). Other independent predictors included a positive cryoglobulin test result (hazard ratio [HR] 7.10, 95% CI 1.74–28.92 [P = 0.006]), male sex (HR 28.73, 95% CI 4.46–144.87 [P = 0.0004]), sensorimotor neuropathy (HR 35.48, 95% CI 5.79–217.39 [P = 0.0001]), and splenomegaly (HR 19.9, 95% CI 4.4–90 [P = 0.0001]).ConclusionThe presence of ectopic GC‐like structures in MSG biopsy tissue is associated with the risk of lymphoma in patients with primary SS. These data reinforce the major role of MSG biopsy tissue in primary SS, for the identification a priori of a subgroup of patients with the highest risk of lymphoma.

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study

Autoimmunity reviews · 2019

📚 38 citations🎯 RCR 2.26Top 23% NIH🔓 Open Access

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MME Aïssatou DIALLO

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (20) — classées par pathologie

Transversal12

Épidémiologie & registres2

Essai clinique2

Pédiatrie2

Sjögren2

Lupus1

Qualité de vie / PROMs1

Vraie vie / RWE1

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