📇 Rhumatologue · LA ROCHELLE · (17) · Libéral

MME CLAIRE DENIS

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9 articles scientifiques publiés — formation continue solide
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120.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LA ROCHELLE (17)LibéralRPPS 10100925220

📊 Reconnaissance scientifique : 7/100📝 13 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Blocking von Willebrand factor for treatment of cutaneous inflammation

The Journal of investigative dermatology · 2014

📚 61 citations🎯 RCR 2.05🔓 Open Access📄 PDF gratuit ↗

Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects

Journal of medical virology · 2003

📚 31 citations

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AbstractEnterovirus RNA has been found previously in specimens of muscle biopsy from patients with idiopathic dilated cardiomyopathy, chronic inflammatory muscle diseases, and fibromyalgia or chronic fatigue syndrome (fibromyalgia/chronic fatigue syndrome). These results suggest that skeletal muscle may host enteroviral persistent infection. To test this hypothesis, we investigated by reverse transcription‐polymerase chain reaction (RT‐PCR) assay the presence of enterovirus in skeletal muscle of patients with chronic inflammatory muscle diseases or fibromyalgia/chronic fatigue syndrome, and also of healthy subjects. Three of 15 (20%) patients with chronic inflammatory muscle diseases, 4 of 30 (13%) patients with fibromyalgia/chronic fatigue syndrome, and none of 29 healthy subjects was found positive. The presence of VP‐1 enteroviral capsid protein was assessed by an immunostaining technique using the 5‐D8/1 monoclonal antibody; no biopsy muscle from any patient or healthy subject was found positive. The presence of viral RNA in some muscle biopsies from patients exhibiting muscle disease, together with the absence of VP‐1 protein, is in favor of a persistent infection involving defective viral replication. J. Med. Virol. 71:540–547, 2003. © 2003 Wiley‐Liss, Inc.

Depressive Symptoms and Suicidal Thoughts in Restless Legs Syndrome

Movement disorders : official journal of the Movement Disorder Society · 2022

📚 24 citations🎯 RCR 3.13Top 15% NIH

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AbstractBackgroundWhether depression and suicide thoughts relate to restless legs syndrome (RLS) or comorbidities associated with RLS remain unclear.ObjectivesTo determine frequency of depressive symptoms and suicidal thoughts in patients with RLS and their change after RLS treatment, associated clinical and polysomnographic factors, and current major depressive episode (MDE) frequency and suicide risk in RLS.MethodsOverall, 549 untreated patients with RLS and 549 age‐, sex‐, and education level‐matched controls completed a standardized evaluation, including the Beck Depression Inventory‐II that has one item on suicide thoughts. Patients underwent a polysomnographic recording and completed the Urgency, Premeditation, Perseverance, Sensation Seeking Impulsive Behavior scale. In a subgroup of 153 patients, current MDE and suicide risk were assessed with the face‐to‐face Mini‐International Neuropsychiatric Interview (MINI). A subgroup of 152 patients were evaluated in untreated and treated conditions.ResultsThe frequency of depressive symptoms (32.5%) and suicidal thoughts (28%) was 10‐fold and 3‐fold higher, respectively, in patients with RLS than controls. Current MDE (10.5%) and suicidal risk (19.9%) (MINI) were also high. Moderate‐to‐severe depressive symptoms were associated with young age, female sex, insomnia symptoms, and urgency dimension. The suicide risk was associated with depression, impulsiveness, and RLS severity. RLS treatment improved depressive symptoms but not suicidal thoughts.ConclusionThe rate of depressive symptoms, depression, and suicidal thoughts/risk was higher in patients with RLS, with key associations with insomnia symptoms, urgency dimension, and RLS severity. These results emphasize the importance of detecting these symptoms in current practice and of evaluating their change after treatment, especially in young women, to improve RLS management. © 2022 International Parkinson and Movement Disorder Society

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MME CLAIRE DENIS

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Publications scientifiques (9) — classées par pathologie

Santé mentale / fatigue4

Transversal3

Essai clinique1

Lombalgie1

Pharmacovigilance1

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