📇 Rhumatologue · LA TRONCHE · (38) · Hospitalier

M MAURICE DEMATTEIS

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4 raisons identifiées

Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (2 thèses dirigées)
Expérience confirmée
25 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
120.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LA TRONCHE (38)HospitalierRPPS 10002996352

EnseignementExpérience confirmée

25ans d'exercice (thèse 2001)

📊 Reconnaissance scientifique : 27/100📝 98 articles publiés🇫🇷 Publications académiques françaises (8)🎓 2 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Intermittent hypoxia induces early functional cardiovascular remodeling in mice

American journal of respiratory and critical care medicine · 2008

📚 139 citations🎯 RCR 3.98Top 11% NIH

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Abstract Rationale Intermittent hypoxia, a hallmark of sleep apnea, is a major factor for hypertension and impaired vasoreactivity. Objectives To examine the temporal occurrence of these two outcomes in order to provide insight into mechanisms and early cardiovascular disease identification. Methods Functional and structural cardiovascular alterations were assessed in C57BL6 mice exposed to intermittent hypoxia (21–4% FiO2, 30-s cycle, 8 h/d) or air for up to 35 days. Blood pressure, heart rate, and urinary catecholamines were measured at Days 1 and 14. Hindquarter vasoreactivity was assessed at Days 14 and 35, including vasoconstriction to norepinephrine, endothelium-, and non–endothelium-dependent vasodilation. Aorta, heart, and hindquarter skeletal muscles were immunostained for vascular markers PECAM-1 and collagen IV. Measurements and Main Results Hemodynamic alterations occurred from Day 1, characterized by blood pressure surges with bradytachyarrhythmia driven by cyclic hypoxia. At Day 14, blood pressure at normoxia was elevated, with predominant diastolic increase. With hypoxia, vasopressive catecholamines were elevated, blood pressure surged with a lower hypoxic threshold, whereas heart rate fluctuations decreased. Histologic alterations started from Day 14, with decreased endothelial PECAM-1 expression in descending aorta and left heart. Impaired peripheral vasoreactivity occurred at Day 35, including hypervasoconstriction to norepinephrine secondary to sympathetic hyperactivity, without changes in pre- and postsynaptic α-adrenoceptors or in endothelium- and non–endothelium-dependent vasodilation. Conclusions Intermittent hypoxia induces sequential cardiovascular events suggesting increased chemoreflex and depressed baroreflex, resulting in sympathoadrenal hyperactivity, early hemodynamic alterations with proximal histologic remodeling, and delayed changes in peripheral vasoreactivity. Such early alterations before overt cardiovascular disease strengthen the need for identifying at-risk individuals for systematic treatment.

Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease

ILAR journal · 2009

📚 108 citations🎯 RCR 3.28Top 14% NIH🔓 Open Access📄 PDF gratuit ↗

The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition

American journal of respiratory and critical care medicine · 2011

📚 107 citations🎯 RCR 3.20Top 15% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Rationale The highly prevalent obstructive sleep apnea syndrome (OSA) with its main component intermittent hypoxia (IH) is a risk factor for cardiovascular mortality. The poor knowledge of its pathophysiology has limited the development of specific treatments, whereas the gold standard treatment, continuous positive airway pressure, may not fully reverse the chronic consequences of OSA and has limited acceptance in some patients. Objectives To examine the contribution of IH-induced inflammation to the cardiovascular complications of OSA. Methods We investigated systemic and vascular inflammatory changes in C57BL6 mice exposed to IH (21–5% FiO2, 60-s cycle) or normoxia 8 hours per day up to 14 days. Vascular alterations were reassessed in mice treated with a blocking antibody of regulated upon activation, normal T-cell expressed and secreted (RANTES)/CC chemokine ligand 5 (CCL5) signaling pathway, or with the IgG isotype control throughout the IH exposure. Measurements and Main Results IH induced systemic inflammation combining increased splenic lymphocyte proliferation and chemokine expression, with early and predominant RANTES/CCL5 alterations, and enhanced splenocyte migration toward RANTES/CCL5. IH also induced structural and inflammatory vascular alterations. Leukocyte–endothelium adhesive interactions were increased, attested by leukocyte rolling and intercellular adhesion molecule-1 expression in mesenteric vessels. Aortas had increased intima–media thickness with elastic fiber alterations, mucoid depositions, nuclear factor-κB–p50 and intercellular adhesion molecule-1 overexpression, hypertrophy of smooth-muscle cells overexpressing RANTES/CCL5, and adventitial–periadventitial T-lymphocyte infiltration. RANTES/CCL5 neutralization prevented both intima–media thickening and inflammatory alterations, independently of the IH-associated proatherogenic dyslipidemia. Conclusions Inflammation is a determinant mechanism for IH-induced preatherosclerotic remodeling involving RANTES/CCL5, a key chemokine in atherogenesis. Characterization of the inflammatory response could allow identifying at-risk patients for complications, and its pharmacologic manipulation may represent a potential complementary treatment of sleep apnea consequences.

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M MAURICE DEMATTEIS

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Thèses universitaires

Direction de thèses

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

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Top publications · les plus citées

Publications scientifiques (26) — classées par pathologie

Transversal10

Santé mentale / fatigue7

Essai clinique3

Revue générale3

Recommandations2

Épidémiologie & registres1

Pharmacovigilance1

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