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4 raisons identifiées
Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (2 thèses dirigées)
Expérience confirmée
25 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
120.1 rhumatos / 100 000 hab. — département bien doté
25ans d'exercice (thèse 2001)
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
✨ Génération du profil synthétique IA en cours…
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Intoxications médicamenteuses volontaires répétées : une conduite addictive plutôt que suicidaire. Phénotypage clinique et modélisation comportementale par une approche dimensionnelle
2016Doctorant·e : Lucie Pennel
Syndrome d'apnées obstructives du sommeil et risque cardiovasculaire : rôle du tissu adipeux viscéral dans les troubles métaboliques et l'athérosclérose induits par l'hypoxie intermittente
2013Doctorant·e : Laureline Poulain
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
27
27 articles ont été cités au moins 27fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
2 831
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
98
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
48
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Inserm · Grenoble Institute of Neurosciences · Université Grenoble Alpes
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Early Increase in Blood–Brain Barrier Permeability in a Murine Model Exposed to Fifteen Days of Intermittent Hypoxia
2024ArticleInternational Journal of Molecular Sciences
Could reasons for admission help to screen unhealthy alcohol use in emergency departments? A multicenter French study
2023ArticleFrontiers in Psychiatry
Long-Acting Buprenorphine Formulations as a New Strategy for the Treatment of Opioid Use Disorder
2023ArticleJournal of Clinical Medicine
Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration
2023ArticleAlcohol and Alcoholism
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
2022ArticleJournal of Psychopharmacology
What Is the Potential for Abuse of Lisdexamfetamine in Adults? A Preclinical and Clinical Literature Review and Expert Opinion
2022ArticleExpert Rev Clin Pharmacol
Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy
2021ArticleAlcoholism: Clinical and Experimental Research
Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients
2021ArticleFrontiers in Psychiatry
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
HOPITAL NORD - CHU38
BD DE LA CHANTOURNE, 38700 LA TRONCHE
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
American journal of respiratory and critical care medicine · 2008
Abstract Rationale Intermittent hypoxia, a hallmark of sleep apnea, is a major factor for hypertension and impaired vasoreactivity. Objectives To examine the temporal occurrence of these two outcomes in order to provide insight into mechanisms and early cardiovascular disease identification. Methods Functional and structural cardiovascular alterations were assessed in C57BL6 mice exposed to intermittent hypoxia (21–4% FiO2, 30-s cycle, 8 h/d) or air for up to 35 days. Blood pressure, heart rate, and urinary catecholamines were measured at Days 1 and 14. Hindquarter vasoreactivity was assessed at Days 14 and 35, including vasoconstriction to norepinephrine, endothelium-, and non–endothelium-dependent vasodilation. Aorta, heart, and hindquarter skeletal muscles were immunostained for vascular markers PECAM-1 and collagen IV. Measurements and Main Results Hemodynamic alterations occurred from Day 1, characterized by blood pressure surges with bradytachyarrhythmia driven by cyclic hypoxia. At Day 14, blood pressure at normoxia was elevated, with predominant diastolic increase. With hypoxia, vasopressive catecholamines were elevated, blood pressure surged with a lower hypoxic threshold, whereas heart rate fluctuations decreased. Histologic alterations started from Day 14, with decreased endothelial PECAM-1 expression in descending aorta and left heart. Impaired peripheral vasoreactivity occurred at Day 35, including hypervasoconstriction to norepinephrine secondary to sympathetic hyperactivity, without changes in pre- and postsynaptic α-adrenoceptors or in endothelium- and non–endothelium-dependent vasodilation. Conclusions Intermittent hypoxia induces sequential cardiovascular events suggesting increased chemoreflex and depressed baroreflex, resulting in sympathoadrenal hyperactivity, early hemodynamic alterations with proximal histologic remodeling, and delayed changes in peripheral vasoreactivity. Such early alterations before overt cardiovascular disease strengthen the need for identifying at-risk individuals for systematic treatment.
American journal of respiratory and critical care medicine · 2011
Abstract Rationale The highly prevalent obstructive sleep apnea syndrome (OSA) with its main component intermittent hypoxia (IH) is a risk factor for cardiovascular mortality. The poor knowledge of its pathophysiology has limited the development of specific treatments, whereas the gold standard treatment, continuous positive airway pressure, may not fully reverse the chronic consequences of OSA and has limited acceptance in some patients. Objectives To examine the contribution of IH-induced inflammation to the cardiovascular complications of OSA. Methods We investigated systemic and vascular inflammatory changes in C57BL6 mice exposed to IH (21–5% FiO2, 60-s cycle) or normoxia 8 hours per day up to 14 days. Vascular alterations were reassessed in mice treated with a blocking antibody of regulated upon activation, normal T-cell expressed and secreted (RANTES)/CC chemokine ligand 5 (CCL5) signaling pathway, or with the IgG isotype control throughout the IH exposure. Measurements and Main Results IH induced systemic inflammation combining increased splenic lymphocyte proliferation and chemokine expression, with early and predominant RANTES/CCL5 alterations, and enhanced splenocyte migration toward RANTES/CCL5. IH also induced structural and inflammatory vascular alterations. Leukocyte–endothelium adhesive interactions were increased, attested by leukocyte rolling and intercellular adhesion molecule-1 expression in mesenteric vessels. Aortas had increased intima–media thickness with elastic fiber alterations, mucoid depositions, nuclear factor-κB–p50 and intercellular adhesion molecule-1 overexpression, hypertrophy of smooth-muscle cells overexpressing RANTES/CCL5, and adventitial–periadventitial T-lymphocyte infiltration. RANTES/CCL5 neutralization prevented both intima–media thickening and inflammatory alterations, independently of the IH-associated proatherogenic dyslipidemia. Conclusions Inflammation is a determinant mechanism for IH-induced preatherosclerotic remodeling involving RANTES/CCL5, a key chemokine in atherogenesis. Characterization of the inflammatory response could allow identifying at-risk patients for complications, and its pharmacologic manipulation may represent a potential complementary treatment of sleep apnea consequences.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of clinical medicine · 2026 · Journal Article
Carbone MG, Maremmani I, Della Rocca F, Gastaldello G, et al.
Journal of clinical medicine · 2023 · Journal Article
Maremmani I, Dematteis M, Gorzelanczyk EJ, Mugelli A, et al.
Alcohol and alcoholism (Oxford, Oxfordshire) · 2023 · Journal Article
Guiraud J, Addolorato G, Aubin HJ, Bachelot S, et al.
The International journal on drug policy · 2020 · Journal Article
Alho H, Dematteis M, Lembo D, Maremmani I, et al.
Drug and alcohol dependence · 2017 · Comparative Study
Rolland B, Chazeron I, Carpentier F, Moustafa F, et al.
Journal of affective disorders · 2015 · Journal Article
Pennel L, Quesada JL, Begue L, Dematteis M
American journal of respiratory and critical care medicine · 2011 · Journal Article
Arnaud C, Beguin PC, Lantuejoul S, Pepin JL, et al.
American journal of respiratory and critical care medicine · 2008 · Journal Article
Dematteis M, Julien C, Guillermet C, Sturm N, et al.
IEEE transactions on bio-medical engineering · 2005 · Clinical Trial
Guméry PY, Roux-Buisson H, Meignen S, Comyn FL, et al.
Epileptic disorders : international epilepsy journal with videotape · 2003 · Case Reports
Dematteis M, Kahane P, Vercueil L, Depaulis A
Clocks & sleep · 2021 · Journal Article
Leenaars CHC, Van der Mierden S, Joosten RNJMA, Van der Weide MA, et al.
Sleep · 2015 · Journal Article
Sapin E, Peyron C, Roche F, Gay N, et al.
Journal of addiction medicine · 2015 · Journal Article
Perney P, Rigole H, Mason B, Dematteis M, et al.
Journal of psychopharmacology (Oxford, England) · 2022 · Journal Article
Guiraud J, Addolorato G, Antonelli M, Aubin HJ, et al.
Alcoholism, clinical and experimental research · 2021 · Journal Article
Scherrer B, Guiraud J, Addolorato G, Aubin HJ, et al.
Expert review of clinical pharmacology · 2022 · Journal Article
Carton L, Icick R, Weibel S, Dematteis M, et al.
Clocks & sleep · 2021 · Journal Article
Leenaars CHC, Van der Mierden S, Joosten RNJMA, Van der Weide MA, et al.
International journal of environmental research and public health · 2013 · Journal Article
Zerhouni O, Bègue L, Brousse G, Carpentier F, et al.
Journal of addiction medicine · 2020 · Journal Article
Kraus M, Lintzeris N, Bhaskar A, Alho H, et al.
Expert opinion on pharmacotherapy · 2017 · Journal Article
Dematteis M, Auriacombe M, D'Agnone O, Somaini L, et al.
Frontiers in psychiatry · 2021 · Journal Article
Delorme J, Pennel L, Brousse G, Daulouède JP, et al.
Addiction biology · 2018 · Journal Article
van den Brink W, Addolorato G, Aubin HJ, Benyamina A, et al.
sj-rar-2-jop-10.1177_02698811221104063 – Supplemental material for Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Supplemental material, sj-rar-2-jop-10.1177_02698811221104063 for Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlle
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Background:Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small randomized controlled trials (RCTs). These results needed to be con
sj-rar-2-jop-10.1177_02698811221104063 – Supplemental material for Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Supplemental material, sj-rar-2-jop-10.1177_02698811221104063 for Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlle
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Background:Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small randomized controlled trials (RCTs). These results needed to be con
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Frontiers in bioscience (Elite edition) · 2012 · Journal Article
Levy P, Tamisier R, Arnaud C, Monneret D, et al.
Seminars in immunopathology · 2009 · Journal Article
Arnaud C, Dematteis M, Pepin JL, Baguet JP, et al.
Progress in cardiovascular diseases · 2009 · Journal Article
Lévy P, Pépin JL, Arnaud C, Baguet JP, et al.
ILAR journal · 2009 · Journal Article
Dematteis M, Godin-Ribuot D, Arnaud C, Ribuot C, et al.
Alcohol and alcoholism (Oxford, Oxfordshire) · 2017 · Journal Article
Reynaud M, Aubin HJ, Trinquet F, Zakine B, et al.