📇 Rhumatologue · COMPIEGNE · (60) · Libéral
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Praticien-chercheur
11 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
73.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR TIFENN DEFOSSEZ - TOUZART
MAISON MEDICALE 9 RUE JEAN JACQUES BERNARD, 60200 COMPIEGNE
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Lupus · 2021
Introduction Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has a protracted course requiring long-term immunosuppressive therapy. Due to the rarity of this syndrome and paucity of reported cases, there is lack of standardized management. We herewith report 5 children with pSLE with LAHPS. Methodology: We retrospectively reviewed clinical features, laboratory features, treatment and outcome for 5 children with lupus anticoagulant hypoprothrombinemia syndrome with SLE and a review of literature of similar cases published. Results Mean age of presentation was 10.2 ± 2.38 years (mean ± SD) and female to male ratio was 4:1. All children presented with mild to severe bleeding manifestations like gum bleed, epistaxis, hematuria, menorrhagia and subarachnoid bleed. Coagulation profile revealed prolonged PT and aPTT, with low prothrombin levels and positive Lupus anticoagulant in all children. Mixing studies were characteristic in these children. On comparing laboratory parameters majority had low C3, C4 levels, ANA and anti-DsDNA antibody positivity and three children had anticardiolipin positivity. One child had lupus nephritis along with LAHPS at presentation. All responded well to steroids and supportive measures. Conclusion High index of suspicion is needed when child with lupus presents with bleeding manifestations for early diagnosis and treatment.
Osteoarthritis and cartilage open · 2021
Journal of orthopaedic case reports · 2021
Introduction:Alkaptonuria is a rare autosomal recessive metabolic disorder characterized by accumulation of homogentisic acid (HGA) due to an inherited deficiency of the enzyme HGA oxidase. Unlike rheumatoid arthritis which affects the small joints of the hands and feet, ochronotic arthropathy predominantly involves the large weight-bearing joints such as hips, knees, and spine. The knee is the most common joint to be affected. Ochronotic arthropathy is usually managed conservatively, but for severely affected hip and knee joints, replacement is considered. Case Report:This report describes a case of 57-year-old male who presented with bilateral knee osteoarthritis who was incidentally diagnosed with ochronosis intraoperatively during total knee arthroplasty, its challenges faced and post-operative functional outcome after 18 months follow-up. Conclusion:This case report highlights the need for high index of suspicion for preoperative diagnosis of ochronotic arthropathy. Difficult spinal anesthesia should be anticipated. Friable and stiff tendon due to ochronotic involvement can put the extensor tendon at risk of rupture during retraction of patella intraoperatively. Post-operative active quadriceps rehabilitation should be done with caution due to friable tendon. Keywords:Alkaptonuria, ochronosis, ochronotic arthropathy, autosomal recessive, total knee arthroplasty.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of orthopaedic case reports · 2024 · Case Reports
Palasseril AS, Chegu M, Shahul MR, T GM
Journal of orthopaedic case reports · 2021 · Case Reports
G S, John JT, Nair DS, Yadav S, et al.
Journal of orthopaedic case reports · 2016 · Case Reports
Ay GR, D SR, T C, C K, et al.
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
The Journal of the Association of Physicians of India · 2017 · Journal Article
Mathew AJ, Ganapati A, T SK, Goel R, et al.
Cureus · 2024 · Case Reports
Nilofar F, Mohanasundaram K, Kumar M, T G
Lupus · 2021 · Case Reports
Kocheril AP, Vettiyil GI, George AS, Shah S, et al.
Cureus · 2025 · Journal Article
Das S, Kotwal V, Thakur A, T L, et al.
World journal of orthopedics · 2025 · Journal Article
Yeo PY, Kasivishvanaath A, Pérez-Carro L, T J
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
Journal of hand and microsurgery · 2022 · Journal Article
T J, Stewart CJ, Tong PY, Lam WL, et al.
Cureus · 2025 · Journal Article
Das S, Kotwal V, Thakur A, T L, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.