📇 Rhumatologue · BLOIS CEDEX · (41) · Salarié

M Boubacar COULIBALY

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Auteur de référence en rhumatologie
34 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
86 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 BLOIS CEDEX (41)SalariéRPPS 10109877273

📊 Reconnaissance scientifique : 34/100📝 201 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

The Journal of experimental medicine · 2022

📚 58 citations🎯 RCR 3.93Top 11% NIH🔓 Open Access📄 PDF gratuit ↗

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Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven children from five unrelated kindreds of western Polynesian ancestry who suffered from severe viral diseases. All the patients are homozygous for the same nonsense IFNAR1 variant (p.Glu386*). This allele encodes a truncated protein that is absent from the cell surface and is loss-of-function. The fibroblasts of the patients do not respond to type I IFNs (IFN-α2, IFN-ω, or IFN-β). Remarkably, this IFNAR1 variant has a minor allele frequency &gt;1% in Samoa and is also observed in the Cook, Society, Marquesas, and Austral islands, as well as Fiji, whereas it is extremely rare or absent in the other populations tested, including those of the Pacific region. Inherited IFNAR1 deficiency should be considered in individuals of Polynesian ancestry with severe viral illnesses.

Effect of Commonly Used Pediatric Antibiotics on Gut Microbial Diversity in Preschool Children in Burkina Faso: A Randomized Clinical Trial

Open forum infectious diseases · 2018

📚 49 citations🎯 RCR 2.06🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Exposure to antibiotics may result in alterations to the composition of intestinal microbiota. However, few trials have been conducted, and observational studies are subject to confounding by indication. We conducted a randomized controlled trial to determine the effect of 3 commonly used pediatric antibiotics on the intestinal microbiome in healthy preschool children. Methods Children aged 6–59 months were randomized (1:1:1:1) to a 5-day course of 1 of 3 antibiotics, including amoxicillin (25 mg/kg/d twice-daily doses), azithromycin (10 mg/kg dose on day 1 and then 5 mg/kg once daily for 4 days), cotrimoxazole (240 mg once daily), or placebo. Rectal swabs were obtained at baseline and 5 days after the last dose and were processed using 16S rRNA gene sequencing. The prespecified primary outcome was inverse Simpson’s α-diversity index. Results Post-treatment Simpson’s diversity was significantly different across the 4 arms (P = .003). The mean Simpson’s α-diversity among azithromycin-treated children was significantly lower than in placebo-treated children (6.6; 95% confidence interval [CI], 5.5–7.8; vs 9.8; 95% CI, 8.7–10.9; P = .0001). Diversity in children treated with amoxicillin (8.3; 95% CI, 7.0–9.6; P = .09) or cotrimoxazole (8.3; 95% CI, 8.2–9.7; P = .08) was not significantly different than placebo. Conclusions Azithromycin affects the composition of the pediatric intestinal microbiome. The effect of amoxicillin and cotrimoxazole on microbiome composition was less clear. Clinical Trials Registration clinicaltrials.gov NCT03187834.

A Two-Center Randomized Trial of an Additional Early Dose of Measles Vaccine: Effects on Mortality and Measles Antibody Levels

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018

📚 38 citations🎯 RCR 1.98🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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M Boubacar COULIBALY

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Publications académiques en France

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Publications scientifiques (34) — classées par pathologie

Essai clinique19

Pédiatrie14

Transversal6

Microbiote4

Vraie vie / RWE2

Génétique1

Pharmacovigilance1

Risque cardio-vasculaire1

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