📇 Rhumatologue · ST NAZAIRE CEDEX · (44) · Libéral
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129.9 rhumatos / 100 000 hab. — département bien doté
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Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
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CABINET PRIVE DU DR Manon CLEMENT
CITE SANITAIRE GEORGES CHARPAK CH DE SAINT NAZAIRE 11 BD GEORGES CHARPAK BP 414, 44606 ST NAZAIRE CEDEX
CH DE SAINT NAZAIRE
CITE SANITAIRE GEORGES CHARPAK 11 BD GEORGES CHARPAK BP 414, 44606 ST NAZAIRE CEDEX
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005
Abstract We sought to determine whether risedronate can preserve cortical bone mass and mechanical properties during long-term disuse in dogs, assessed by histomorphometry and biomechanics on metacarpal diaphyses. Risedronate slowed cortical thinning and partially preserved mechanical properties, but it was unable to suppress bone loss to the degree seen in other osteoporoses. Introduction: Disuse induces dramatic bone loss resulting from greatly elevated osteoclastic resorption. Targeting osteoclasts with antiresorptive agents, such as bisphosphonates, should be an effective countermeasure for preventing disuse osteoporosis. Materials and Methods: Single forelimbs from beagles (5–7 years old, n = 28) were immobilized (IM) for 12 months. Age-matched, non-IM dogs served as controls. One-half the animals received either risedronate (RIS, 1 mg/kg) or vehicle daily. Histomorphometry was performed on second metacarpal mid-diaphyses. Cortical mechanical properties were determined by testing third metacarpal diaphyses in four-point bending. Results: IM caused marked reduction in cortical area (−42%) and cortical thinning (−40%) through endocortical resorption, extensive intracortical tunneling, and periosteal resorption; both bone resorption and formation were significantly elevated over control levels on all envelopes. IM also decreased maximum load and stiffness by ∼80% compared with controls. RIS reduced both periosteal bone loss and marrow cavity expansion; however, cortical area remained significantly lower in RIS-treated IM animals than in untreated non-IM controls (−16%). RIS also increased resorption indices in all envelopes compared with nontreated IM, indicating that RIS suppressed osteoclast activity but not osteoclast recruitment. RIS did not affect bone formation. RIS treatment conserved some whole bone mechanical properties, but they were still significantly lower than in controls. There were no significant differences in tissue level material properties among the groups. Conclusion: RIS treatment reduces cortical bone loss at periosteal and endocortical surfaces caused by long-term immobilization, thus partially conserving tissue mechanical properties. This modest effect contrasts with more dramatic actions of the bisphosphonate in other osteoporoses. Our results suggest that risedronate impairs osteoclastic function but cannot completely overcome the intense stimulus for osteoclast recruitment during prolonged disuse.
Journal of autoimmunity · 2015
Journal of wildlife diseases · 2019
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of autoimmunity · 2015 · Journal Article
Clement M, Charles N, Escoubet B, Guedj K, et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005 · Comparative Study
Li CY, Price C, Delisser K, Nasser P, et al.
Journal of wildlife diseases · 2019 · Journal Article
Justice-Allen A, Clement MJ