📇 Rhumatologue · BLOIS CEDEX · (41) · Salarié

M JEREMY CLEMENT

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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
86 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 BLOIS CEDEX (41)SalariéRPPS 10101758380

📊 Reconnaissance scientifique : 6/100📝 17 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Soft tissue artifact compensation in knee kinematics by multi-body optimization: Performance of subject-specific knee joint models

Journal of biomechanics · 2015

📚 47 citations🎯 RCR 3.51Top 13% NIH

The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue

Bone reports · 2015

📚 36 citations🎯 RCR 2.12Top 25% NIH🔓 Open Access

Increased N-linked glycosylation leading to oversialylation of monomeric immunoglobulin A1 from patients with Sjögren's syndrome

Scandinavian journal of immunology · 2000

📚 34 citations🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains more sialic acid (SA) in patients than in controls, as determined by enzyme‐linked immunosorbent assay (ELISA) and Western blot with Sambucus nigra agglutinin (SNA), a lectin specific for SA. To localize this excess of SA on the N‐ and/or O‐linked oligosaccharides, we analysed them separately, using N‐ and O‐linked oligosaccharide profiling kits based on fluorophore‐assisted carbohydrate electophoresis. N‐linked, but not O‐linked, oligosaccharides of patients' IgA1 were oversialylated, and this seemed to be linked to an excess of SA on the same number of polysaccharides as normal IgA1. To localize the abnormality to the Fab and/or Fc fragments, monomeric IgA1 was digested with protease, separated and transferred to nitrocellulose, where SA was identified by SNA. Both Fab and Fc fragments appeared to be oversialylated. Oversialylation of N‐linked oligosaccharides of IgA1 from patients with pSS might prevent the recognition of IgA by receptors that are responsible for their clearance, resulting in an excess of serum IgA and related immune complexes.

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M JEREMY CLEMENT

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Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (20) — classées par pathologie

Transversal11

Pédiatrie3

Essai clinique2

Ostéoporose2

Biothérapies non-anti-TNF1

Sjögren1

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