📇 Rhumatologue · FREJUS CEDEX · (83) · Salarié
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
2 raisons identifiées
Praticien-chercheur
7 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
118.8 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
18
18 articles ont été cités au moins 18fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
1 649
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
37
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
24
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Institute Cancer De La Loire Lucien Neuwirth · Centre Hospitalier Universitaire de Saint-Étienne
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Un programme R d'allocation à objectifs multiples utilisant l'optimisation convexe, application aux enquêtes entreprises
2025Congrès15e Journées de méthodologie statistique de l’Insee - JMS 2025
Properties and comparison of some Kriging sub-model aggregation methods
2022ArticleMathematical Geosciences
Safety and efficacy of emergency transarterial embolization for mesenteric bleeding
2022ArticleCvir Endovascular
Adaptive Design of Experiments for Conservative Estimation of Excursion Sets
2021ArticleTechnometrics
Nested Kriging predictions for datasets with large number of observations
2018ArticleStatistics and Computing
A targeted 3D EM and correlative microscopy method using SEM array tomography
2018ArticleDevelopment (Cambridge, England)
Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
2017ArticleClinical Cancer Research
Site-Directed Chemical Probing to map transient RNA/protein interactions
2017ArticleMethods
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CHI DE FREJUS SAINT RAPHAEL
240 AV DE SAINT LAMBERT CS 90110, 83608 FREJUS CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Cell metabolism · 2020
Clinical cancer research : an official journal of the American Association for Cancer Research · 2017
Abstract Purpose: AXL receptor tyrosine kinase has been described as a relevant molecular marker and a key player in invasiveness, especially in triple-negative breast cancer (TNBC). Experimental Design: We evaluate the antitumor efficacy of the anti-AXL monoclonal antibody 20G7-D9 in several TNBC cell xenografts or patient-derived xenograft (PDX) models and decipher the underlying mechanisms. In a dataset of 254 basal-like breast cancer samples, genes correlated with AXL expression are enriched in EMT, migration, and invasion signaling pathways. Results: Treatment with 20G7-D9 inhibited tumor growth and bone metastasis formation in AXL-positive TNBC cell xenografts or PDX, but not in AXL-negative PDX, highlighting AXL role in cancer growth and invasion. In vitro stimulation of AXL-positive cancer cells by its ligand GAS6 induced the expression of several EMT-associated genes (SNAIL, SLUG, and VIM) through an intracellular signaling implicating the transcription factor FRA-1, important in cell invasion and plasticity, and increased their migration/invasion capacity. 20G7-D9 induced AXL degradation and inhibited all AXL/GAS6–dependent cell signaling implicated in EMT and in cell migration/invasion. Conclusions: The anti-AXL antibody 20G7-D9 represents a promising therapeutic strategy in TNBC with mesenchymal features by inhibiting AXL-dependent EMT, tumor growth, and metastasis formation. Clin Cancer Res; 23(11); 2806–16. ©2016 AACR.
Genome research · 2017
Retroelements, the prevalent class of plant transposons, have major impacts on host genome integrity and evolution. They produce multiple proteins from highly compact genomes and, similar to viruses, must have evolved original strategies to optimize gene expression, although this aspect has been seldom investigated thus far. Here, we have established a high-resolution transcriptome/translatome map for the near-entirety of Arabidopsis thaliana transposons, using two distinct DNA methylation mutants in which transposon expression is broadly de-repressed. The value of this map to study potentially intact and transcriptionally active transposons in A. thaliana is illustrated by our comprehensive analysis of the cotranscriptional and translational features of Ty1/Copia elements, a family of young and active retroelements in plant genomes, and how such features impact their biology. Genome-wide transcript profiling revealed a unique and widely conserved alternative splicing event coupled to premature termination that allows for the synthesis of a short subgenomic RNA solely dedicated to production of the GAG structural protein and that preferentially associates with polysomes for efficient translation. Mutations engineered in a transgenic version of the Arabidopsis EVD Ty1/Copia element further show how alternative splicing is crucial for the appropriate coordination of full-length and subgenomic RNA transcription. We propose that this hitherto undescribed genome expression strategy, conserved among plant Ty1/Copia elements, enables an excess of structural versus catalytic components, mandatory for mobilization.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of personalized medicine · 2022 · Journal Article
Grange R, Grange L, Chevalier C, Mayaud A, et al.
Journal of personalized medicine · 2022 · Journal Article
Extrat C, Grange S, Mayaud A, Villeneuve L, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2017 · Journal Article
Leconet W, Chentouf M, du Manoir S, Chevalier C, et al.
Genome research · 2017 · Journal Article
Oberlin S, Sarazin A, Chevalier C, Voinnet O, et al.
Cell metabolism · 2020 · Journal Article
Chevalier C, Kieser S, Çolakoğlu M, Hadadi N, et al.
CVIR endovascular · 2022 · Journal Article
Extrat C, Grange S, Chevalier C, Williet N, et al.
International journal of molecular sciences · 2021 · Journal Article
Chivasso C, Hagströmer CJ, Rose KL, Lhotellerie F, et al.
UEFepilepsyAIVI/DeepSqueak: DeepSqueak Screener
Fork of DeepSqueak (Coffey, Marx, Neumaier, 2019), with additional functionalities for e.g. screening of whole records for false negatives.
UEFepilepsyAIVI/DeepSqueak: DeepSqueak Screener
Fork of DeepSqueak (Coffey, Marx, Neumaier, 2019), with additional functionalities for e.g. screening of whole records for false negatives.
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).