Docteur MICHEL CHARPENTIER

Bibliographie

• Environmental preferences of green sea turtles (Chelonia mydas) for egg-laying on a fringing reef pocket beach, Mayotte Island

  2025

  ArticleFrontiers in Marine Science

• Characterisation of long-term evolution (1950–2016) and vulnerability of Mayotte’s shoreline using aerial photographs and a multidisciplinary vulnerability index

  2022

  ArticleRegional Studies in Marine Science

• The baobabs of the Comoro Islands: Some biogeographical factors towards the protection and conservation of a neglected asset

  2019

  ArticleTropical Ecology

• Linguistic Atlas of French Polynesia

  2015

  Ouvrage

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (4)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Les corps tendres de Michel Charpentier - ArtsHebdoMédias

  📰 ArtsHebdoMédias · 29/07/2023

  <a href="https://news.google.com/rss/articles/CBMihwFBVV95cUxQM2FLTHVRZWc4Tmt4b2NGcGp2TDRwWXBLb01sRm9rcFZFZ0ZlbVJyYXV4YUs5ZGRMOEV4YU9iMFZhdFpkTm96b3FxQk5VV2Q1ZkZ5VHYzMHZtY1Q0Ymx3SXphSVNVR1hQYmVpOV8yOFd5ZTk5eHdNT0dEa1duSF82dXBuTEFDVmM?oc=5" target="_blank">Les corps tendres de Michel Charpentier</a>&

• Valmondois : Michel Charpentier accueille ses sculptures au jardin - Le Parisien

  📰 Le Parisien · 08/06/2019

  <a href="https://news.google.com/rss/articles/CBMixgFBVV95cUxQN1o2RXZyclRxa3VmQ0x2S1Q0WWh0WGxPZGhqV00wM25VWmttckItb0lJX0k0MDhRdjJEUE5McUV6X3h2YUhMenZ6Mms0bFJiMjRRdjNiTy1JaTlTSnRQTkRwQzJPUDY0ZkZUZUY5OHBzYkc1ZHVRbi1lQ0pSb1VwUXVNM3dmRzhLSjJXbEJwekhfaFhINzBCSGEtY0szNjlPWDFvbmR5MmpMcUc4a3BfS3dUb3EtTUJvUW

• Les deux médecins de Fontenay-sur-Eure « peinés de partir » - L’Écho Républicain

  📰 L’Écho Républicain · 01/07/2015

  <a href="https://news.google.com/rss/articles/CBMizAFBVV95cUxPcmVjbktNMG5nVDZoRlNRbEc1RjBEdVZOMHc3aDRNSVh5QVAtWEUzalprOTZPQzFWUzV6X2NrZ0plZmhvQXRPX1V6b09tcVdodElmdUwyZG56S2hadl9xRFhpRk43ZjlHVVdkbU5xUGpiYXJJdU1FQ0R3dm5tWk41by1pLWdtdkRKeWNKN29aSWZKZ1Rfc2poaGV0b2FNZGhDNlJJSllVclJMTVRmVHFtd0VuRDB2QXdhbW

• Noël Ballay repose au cimetière communal - L’Écho Républicain

  📰 L’Écho Républicain · 05/11/2021

  <a href="https://news.google.com/rss/articles/CBMiuAFBVV95cUxOZjg3UW5MTTZWSWVMMEdvMERVblIzQWNHX3g2Nmd6Q0Naa1ZKNzNXSGI1NzJqS0ZOalFZc2xBX1ExbUFsd0xaY25yelVnanhyWW9YS2hxYm9LeTFaZ0pmblJCWmVockRneExZb3M3SEhxQkd1UGh3Vk9DcjFISVpXdkdFYzFXSXRCSjNuTHdoUzBsNkRKVWtfVFVFenpRcE94MWlqT0FrNFZYQXdvLUMzdGRoZEJ4UkxF?o

Top publications · les plus citées

• 1

  Compliance with pharmacologic therapy for osteoporosis

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2003

  📚 164 citations🎯 RCR 4.82Top 8% NIH
• 2

  Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

  Journal of medicinal chemistry · 1995

  📚 95 citations🎯 RCR 2.42Top 21% NIH🔓 Open Access
• 3

  Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure

  Circulation · 2020

  📚 75 citations🎯 RCR 4.02Top 11% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Background: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor stimulation. PDE4B deficiency leads to abnormal Ca 2+ handling and PDE4B is decreased in pressure overload hypertrophy, suggesting that increasing PDE4B in the heart is beneficial in heart failure. Methods: We measured PDE4B expression in human cardiac tissues and developed 2 transgenic mouse lines with cardiomyocyte-specific overexpression of PDE4B and an adeno-associated virus serotype 9 encoding PDE4B. Myocardial structure and function were evaluated by echocardiography, ECG, and in Langendorff-perfused hearts. Also, cAMP and PKA (cAMP dependent protein kinase) activity were monitored by Förster resonance energy transfer, L-type Ca 2+ current by whole-cell patch-clamp, and cardiomyocyte shortening and Ca 2+ transients with an Ionoptix system. Heart failure was induced by 2 weeks infusion of isoproterenol or transverse aortic constriction. Cardiac remodeling was evaluated by serial echocardiography, morphometric analysis, and histology. Results: PDE4B protein was decreased in human failing hearts. The first PDE4B-transgenic mouse line (TG15) had a ≈15-fold increase in cardiac cAMP-PDE activity and a ≈30% decrease in cAMP content and fractional shortening associated with a mild cardiac hypertrophy that resorbed with age. Basal ex vivo myocardial function was unchanged, but β-adrenergic receptor stimulation of cardiac inotropy, cAMP, PKA, L-type Ca 2+ current, Ca 2+ transients, and cell contraction were blunted. Endurance capacity and life expectancy were normal. Moreover, these mice were protected from systolic dysfunction, hypertrophy, lung congestion, and fibrosis induced by chronic isoproterenol treatment. In the second PDE4B-transgenic mouse line (TG50), markedly higher PDE4B overexpression, resulting in a ≈50-fold increase in cardiac cAMP-PDE activity caused a ≈50% decrease in fractional shortening, hypertrophy, dilatation, and premature death. In contrast, mice injected with adeno-associated virus serotype 9 encoding PDE4B (10 12 viral particles/mouse) had a ≈50% increase in cardiac cAMP-PDE activity, which did not modify basal cardiac function but efficiently prevented systolic dysfunction, apoptosis, and fibrosis, while attenuating hypertrophy induced by chronic isoproterenol infusion. Similarly, adeno-associated virus serotype 9 encoding PDE4B slowed contractile deterioration, attenuated hypertrophy and lung congestion, and prevented apoptosis and fibrotic remodeling in transverse aortic constriction. Conclusions: Our results indicate that a moderate increase in PDE4B is cardioprotective and suggest that cardiac gene therapy with PDE4B might constitute a new promising approach to treat heart failure.

Publications scientifiques (11) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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