📇 Rhumatologue · ST ETIENNE DE MONTLUC · (44) · Libéral

MME VALERIE BOUSQUET-CREPIN

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
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129.9 rhumatos / 100 000 hab. — département bien doté

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📍 ST ETIENNE DE MONTLUC (44)LibéralRPPS 10001999456

✨ Génération du profil synthétique IA en cours…

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29 BOULEVARD DE LA LIBERATION, 44360 ST ETIENNE DE MONTLUC
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Top publications · les plus citées

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial

Health science reports · 2024

📚 8 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackgroundIn this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second‐line treatment potentiated the objective response rate.Patients/MethodsA multicentre, randomized, open label, phase‐II study was conducted and included 42 patients from July 2009 to January 2017. The primary endpoint was the objective response rate of the docetaxel‐curcumin combination in comparison with docetaxel alone. The secondary endpoints were the assessment of clinical benefit, overall survival, time‐to‐progression, progression‐free survival, compliance, and safety. An interim analysis was planned to evaluate safety and efficacy.ResultsIn this interim analysis conducted on 37 patients (19 in the control group vs. 18 in the experimental group), no difference was observed for the objective response rate (p = 0.25, control 73.7% vs. experimental 55.6%). Concerning clinical benefit, overall survival and time‐to‐progression, we also failed to show any difference between the two arms. A slight tendency towards longer progression‐free survival at 12 months after randomization was observed in the curcumin group (65.5% vs. 41.4%) but this difference did not reach significance (p = 0.14).ConclusionIn this study, we showed for the first time that adding oral curcumin for advanced and metastatic breast cancer patients treated with first or second‐line docetaxel was not efficacious, although safe. Consequently, this study was stopped for reasons of futility. Further studies with a larger number of patients, a different curcumin preparation, a longer treatment period and a pharmacokinetic evaluation of curcumin are needed to explore the real efficacy of this compound.

Specific form of ageism in dental care: Convergent validity of the Ageism Scale for Dental Students and its implications for education

European journal of dental education : official journal of the Association for Dental Education in Europe · 2023

📚 8 citations🎯 RCR 3.28Top 14% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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AbstractIntroductionThe World Health Organisation considers ageism as an important barrier to age‐appropriate care for older adults. An Ageism Scale for Dental Students (ASDS) has been validated in the United States, Brazil, Greece, Romania and in France. At present, the convergent validity of ASDS has never been evaluated. Moreover, a specialised and disciplinary tool as the ASDS may not overlap with more general ageism assessment which may highlight the need for specific courses during the education of the future health professionals.Materials and MethodsThe survey was administered from December 2020 to January 2021. All the undergraduate students of the last 3 years of study at the dental school of Clermont‐Ferrand were invited to complete both scales. Two hundred sixteen students were randomly divided into two equal groups. The first group answered first Aging Semantic Differential‐ ASD then ASDS, the second in reverse order. The convergent validity between ASDS and ASD was assessed by computing a Pearson correlation coefficient and discriminant analysis between each component of the two scales.ResultsThe response rate was of 53.7%. The correlation analysis conducted on the total scores of the ASDS and of the ASD shows a significant, yet weak relationship. The discriminant analysis indicates that only the first component of the ASDS is significantly associated with each dimension of the ASD, whereas the second component is totally independent from the ASD and the third component almost independent from the ASD, except for the integrity dimension.ConclusionsThis specialised questionnaire may assess a form of ageism that is not captured at all in more general scales. Such a scale may help to identify the different dimensions of ageism among dental students which is required to reduce ageism in medical care. This reduction should pass by adapted courses in gerodontology.

The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI

ArXiv · 2024

📚 7 citations🎯 RCR 2.57Top 20% NIH

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MME VALERIE BOUSQUET-CREPIN

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal27

Revue générale6

Lupus4

Case report / série3

Essai clinique2

Pédiatrie2

Qualité de vie / PROMs2

Revue / méta-analyse2

AINS1

Anti-TNF1

csDMARDs1

Économie santé1

Épidémiologie & registres1

Génétique1

Pharmacovigilance1

Vraie vie / RWE1

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