Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
3 raisons identifiées
Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
34 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
129.9 rhumatos / 100 000 hab. — département bien doté
5ans d'exercice (thèse 2021)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Médecine prédictive et personnalisée de la sténose aortique : base génétique et prise en charge thérapeutique personnalisée
Predictive and personalized medicine for aortic stenosis : genetic basis and personalized therapeutic management
Direction : Thierry Le Tourneau, Jean-Jacques Schott
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
20
20 articles ont été cités au moins 20fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
1 289
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
111
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
32
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients
2026ArticleIntensive Care Medicine Experimental
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve
2026ArticleCirculation
Effects of aging on transmission from Ia afferents to α-motoneurons and presynaptic mechanisms across muscle lengths and contraction types
2025ArticleGeroScience
Implicit Shape-Prior for Few-Shot Assisted 3D Segmentation
2025CongrèsInternational Workshop on Shape in Medical Imaging - MICCAI 2025
UNSUPERVISED ANOMALY DETECTION ON IMPLICIT SHAPE REPRESENTATIONS FOR SARCOPENIA DETECTION
2025CongrèsInternational Symposium on Biomedical Imaging
A new bleeding risk score specifically developed for direct oral anticoagulants in a geriatric population
2025ArticleAge and Ageing
Concordance of Freehand 3D Ultrasound Muscle Measurements With Sarcopenia Parameters in a Geriatric Rehabilitation Ward
2024ArticleJournal of Cachexia, Sarcopenia and Muscle
Reliability of a 2D-Panoramic Ultrasound System for the Determination of Muscle Volume in Older Hospitalized Patients
2024ArticleUltrasound Quarterly
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CHU DE NANTES SITE LAENNEC
BD JACQUES MONOD, 44800 ST HERBLAIN
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Circulation. Genomic and precision medicine · 2019
Background: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA and PALMD , have been identified as causal for CAVS. We aimed to identify additional susceptibility genes for CAVS. Methods: A GWAS (genome-wide association study) meta-analysis of 4 cohorts, totaling 5115 cases and 354 072 controls of European descent, was performed. A TWAS (transcriptome-wide association study) was completed to integrate transcriptomic data from 233 human aortic valves. A series of post-GWAS analyses were performed, including fine-mapping, colocalization, phenome-wide association studies, pathway, and tissue enrichment as well as genetic correlation with cardiovascular traits. Results: In the GWAS meta-analysis, 4 loci achieved genome-wide significance, including 2 new loci: IL6 (interleukin 6) on 7p15.3 and ALPL (alkaline phosphatase) on 1p36.12. A TWAS integrating gene expression from 233 human aortic valves identified NAV1 (neuron navigator 1) on 1q32.1 as a new candidate causal gene. The CAVS risk alleles were associated with higher mRNA expression of NAV1 in valve tissues. Fine-mapping identified rs1800795 as the most likely causal variant in the IL6 locus. The signal identified colocalizes with the expression of the IL6 RNA antisense in various tissues. Phenome-wide association analyses in the UK Biobank showed colocalized associations between the risk allele at the IL6 lead variant and higher eosinophil count, pulse pressure, systolic blood pressure, and carotid artery procedures, implicating modulation of the IL6 pathways. The risk allele at the NAV1 lead variant colocalized with higher pulse pressure and higher prevalence of carotid artery stenosis. Association results at the genome-wide scale indicated genetic correlation between CAVS, coronary artery disease, and cardiovascular risk factors. Conclusions: Our study implicates 3 new genetic loci in CAVS pathogenesis, which constitute novel targets for the development of therapeutic agents.
European geriatric medicine · 2022
Abstract Background The Task Force for the diagnosis and management of atrial fibrillation (AF) of the European Society of Cardiology (ESC) published in 2020 the updated Guidelines for the Diagnosis and Management of Atrial Fibrillation with the contribution of the European Heart Rhythm Association (EHRA) of the ESC and the European Association for Cardiothoracic Surgery (EACTS). Methods and results In this narrative viewpoint, we approach AF from the perspective of aging medicine and try to provide the readers with information usually neglected in clinical routine, mainly due to the fact that while the large majority of AF patients in real life are older, frail and cognitively impaired, these are mostly excluded from clinical trials, and physicians’ attitudes often prevail over standardized algorithms. Conclusions On the basis of existing evidence, (1) opportunistic AF screening by pulse palpation or ECG rhythm strip is cost-effective, and (2) whereas advanced chronological age by itself is not a contraindication to AF treatment, a Comprehensive Geriatric Assessment (CGA) including frailty, cognitive impairment, falls and bleeding risk may assist in clinical decision making to provide the best individualized treatment.
BMC geriatrics · 2022
Abstract Background Aging is one of the most important prognostic factors increasing the risk of clinical severity and mortality of COVID-19 infection. However, among patients over 75 years, little is known about post-acute functional decline. Objective The aim of this study was to identify factors associated with functional decline 3 months after COVID-19 onset, to identify long term COVID-19 symptoms and transitions between frailty statesafter COVID-19 onset in older hospitalized patients. Methods This prospective observational study included COVID-19 patients consecutively hospitalized from March to December 2020 in Acute Geriatric Ward in Nantes University Hospital. Functional decline, frailty status and long term symptoms were assessed at 3 month follow up. Functional status was assessed using the Activities of Daily Living simplified scale (ADL). Frailty status was evaluated using Clinical Frailty Scale (CFS). We performed multivariable analyses to identify factors associated with functional decline. Results Among the 318 patients hospitalized for COVID-19 infection, 198 were alive 3 months after discharge. At 3 months, functional decline occurred in 69 (36%) patients. In multivariable analysis, a significant association was found between functional decline and stroke (OR = 4,57, p = 0,003), history of depressive disorder (OR = 3,05, p = 0,016), complications (OR = 2,24, p = 0,039), length of stay (OR = 1,05, p = 0,025) and age (OR = 1,08, p = 0,028). At 3 months, 75 patients described long-term symptoms (49.0%). Of those with frailty (CFS scores ≥5) at 3-months follow-up, 30% were not frail at baseline. Increasing frailty defined by a worse CFS state between baseline and 3 months occurred in 41 patients (26.8%). Conclusions This study provides evidence that both the severity of the COVID-19 infection and preexisting medical conditions correlates with a functional decline at distance of the infection. This encourages practitioners to establish discharge personalized care plan based on a multidimensional geriatric assessment and in parallel on clinical severity evaluation.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Age and ageing · 2025 · Journal Article
Piccoli M, Pisica-Donose G, Hacil A, Orvoën G, et al.
Journal of cachexia, sarcopenia and muscle · 2025 · Journal Article
Huet J, Nordez A, Sarcher A, Mathieu M, et al.
European geriatric medicine · 2024 · Journal Article
Ungar A, Rivasi G, Testa GD, Boureau AS, et al.
Maturitas · 2023 · Editorial
Annweiler C, Noublanche F, Boureau AS, Berrut G
European geriatric medicine · 2022 · Journal Article
Polidori MC, Alves M, Bahat G, Boureau AS, et al.
Gerontology · 2022 · Journal Article
Bobet AS, Brouessard C, Le Tourneau T, Manigold T, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2021 · Journal Article
Berrut G, Boureau AS, Trochu JN, Genet B, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2021 · Journal Article
Levasseur B, Defebvre R, Nourry M, Chapelet G, et al.
The Annals of thoracic surgery · 2021 · Journal Article
Paille M, Senage T, Roussel JC, Manigold T, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2021 · Journal Article
Berrut G, Boureau AS, Trochu JN, Genet B, et al.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine · 2021 · Journal Article
De Carvalho H, Javaudin F, Le Bastard Q, Boureau AS, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2020 · Journal Article
Berrut G, de Decker L, Aquino JP, Ahmine S, et al.
Journal of geriatric oncology · 2020 · Letter
Gouraud-Tanguy A, Boureau AS, Trébern-Launay K, Mathieu M, et al.
BMC geriatrics · 2019 · Journal Article
Dylis A, Boureau AS, Coutant A, Batard E, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2019 · Journal Article
Troudet P, Mignen F, Boureau AS, Berrut G, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2019 · Journal Article
Chapelet G, Boureau AS, Montassier E, Le Bastard Q, et al.
European geriatric medicine · 2018 · Journal Article
Boureau AS, Chapelet G, Paille M, Trochu JN, et al.
BMC sports science, medicine & rehabilitation · 2026 · Journal Article
Komonski A, Meunier C, Boureau AS
Ultrasound quarterly · 2024 · Journal Article
Boureau AS, Anger S, Cornu C, Mathieu M, et al.
European heart journal. Cardiovascular Imaging · 2024 · Journal Article
Guimbretière G, Sénage T, Boureau AS, Roos JC, et al.
European heart journal. Quality of care & clinical outcomes · 2026 · Journal Article
Suc G, Boureau AS, Durand E, Benamer H, et al.
Diabetes care · 2025 · Letter
Christiaens A, Boureau AS, Hadjadj S, Cariou B
Diabetes care · 2025 · Journal Article
Christiaens A, Boureau AS, Guyomarch B, de Decker L, et al.
Circulation · 2026 · Journal Article
Thériault S, Holdcraft JA, Sharipova D, Faucherre A, et al.
Heart (British Cardiac Society) · 2024 · Journal Article
Delwarde C, Toquet C, Boureau AS, Le Ruz R, et al.
Circulation. Genomic and precision medicine · 2019 · Journal Article
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, et al.
Nutrients · 2021 · Journal Article
Mathieu M, Guillot P, Riaudel T, Boureau AS, et al.
Journal of geriatric oncology · 2020 · Letter
Gouraud-Tanguy A, Boureau AS, Trébern-Launay K, Mathieu M, et al.
Diabetologia · 2022 · Clinical Trial
Cariou B, Wargny M, Boureau AS, Smati S, et al.
Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017 · Journal Article
de Decker L, Hanon O, Boureau AS, Chapelet G, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2022 · Journal Article
Berrut G, Piriou N, Boureau AS, Hanon O, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2019 · Journal Article
Chapelet G, Boureau AS, Montassier E, Le Bastard Q, et al.
Geriatrie et psychologie neuropsychiatrie du vieillissement · 2020 · Journal Article
Boureau AS, de Decker L, Berrut G, Hanon O
Antibiotics prescription and guidelines adherence in elderly: impact of the comorbidities
Abstract Background Although the interest of antibiotics is well known, antibiotics prescription is associated with side effect, especially in patients with multiples comorbidities. One way to reduce the incidence of sid
Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study
Abstract Background Aging is one of the most important prognostic factors increasing the risk of clinical severity and mortality of COVID-19 infection. However, among patients over 75 years, little is known about post-ac
Implicit Shape-Prior for Few-Shot Assisted 3D Segmentation
The objective of this paper is to significantly reduce the manual workload required from medical professionals in complex 3D segmentation tasks that cannot be yet fully automated. For instance, in radiotherapy planning,
Antibiotics prescription and guidelines adherence in elderly: impact of the comorbidities
Abstract Background Although the interest of antibiotics is well known, antibiotics prescription is associated with side effect, especially in patients with multiples comorbidities. One way to reduce the incidence of sid
Clinical Characterisation Protocol for Severe Emerging Infections
Infectious disease is the single biggest cause of death worldwide. New infectious agents, such as the SARS, MERS and other novel coronavirus, novel influenza viruses, viruses causing viral haemorrhagic fever (e.g. Ebola)
Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study
Abstract Background Aging is one of the most important prognostic factors increasing the risk of clinical severity and mortality of COVID-19 infection. However, among patients over 75 years, little is known about post-ac
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Journal of clinical medicine · 2021 · Journal Article
Guesneau C, Boureau AS, Bourigault C, Berrut G, et al.
Infection and drug resistance · 2019 · Journal Article
Bachtarzi R, Boureau AS, Mascart C, Batard E, et al.
BMC geriatrics · 2022 · Journal Article
Prampart S, Le Gentil S, Bureau ML, Macchi C, et al.