Docteur ISABELLE BONNET
✨ Profil synthétique
IA · 07/05/2026Le Docteur Isabelle Bonnet est une rhumatologue hospitalière à Nîmes, avec une expérience de recherche dans divers domaines, notamment la microbiologie et l'immunologie. Elle a dirigé des thèses en biologie cellulaire et développement. Ses publications PubMed couvrent des sujets tels que les essais cliniques, les biothérapies et la pharmacovigilance.
Expertises présumées
- Sjögren
- Biothérapies non-anti-TNF
- Essais cliniques
- Pharmacovigilance
- Épidémiologie
- Microbiologie
- Immunologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Rôle de whiB6 et kdpDE dans le clone MDR hypertransmissible B0/W148 de Mycobacterium tuberculosi
2023Role of whiB6 and kdpDE in the successful MDR clone Mycobacterium tuberculosis B0/W148
Microbiologie et immunologie🎓 Sorbonne universitéDirection : Régis Tournebize
Les traumatismes du cartilage triradie
1991Médecine🎓 BesançonDirection : Paul Gille
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Direction de thèses
🎓 1 thèse dirigéeSource theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
17
h articles cités ≥ h fois chacun. Un h de 17 = 17 publications avec 17+ citations.
Citations
1 977
Publications
52
i10-index
20
Thématiques principales
- Cellular Mechanics and Interactions ×18
- 3D Printing in Biomedical Research ×8
- Microtubule and mitosis dynamics ×6
- Neurobiology and Insect Physiology Research ×3
- Gene Regulatory Network Analysis ×3
Affiliations FR : Centre National de la Recherche Scientifique · Université Paris Sciences et Lettres · Sorbonne Université
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays
2025ArticleProceedings of the National Academy of Sciences of the United States of America
Evaluation of the role of <i>whiB6</i> and <i>kdpDE</i> in the dominant multidrug-resistant clone <i>Mycobacterium tuberculosis</i> B0/W148
2025ArticleMicrobiology Spectrum
Do SMS/e-mail reminders increase influenza vaccination of rheumatoid arthritis patients under anti-TNF: a nested randomized controlled trial in the ART e-cohort
2024ArticleRheumatology
Src kinase slows collective rotation of confined epithelial cell monolayers
2024ArticleSoft Matter
Clinico-biological factors predicting the benefit of the LV5FU2 maintenance strategy as a first-line therapy in patients with metastatic pancreatic cancer
2024ArticleOncologist
Canadian banknotes to explore the phenomenon of diffraction
2024ArticleEuropean Journal of Physics
Rôle de whiB6 et kdpDE dans le clone MDR hypertransmissible B0/W148 de Mycobacterium tuberculosi
2023Thèse
Les imaginaires sociaux de la scène de crime dans la photographie contemporaine (1970-2018)
2023Thèse
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
CHU NIMES CAREMEAU
Place DU PROFESSEUR ROBERT DEBRE, 30029 Nîmes
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
Nature communications · 2020
Lire l'abstract Crossref ↓
AbstractAlthough fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopulations in metastatic lymph nodes (LN). Two myofibroblastic subsets, CAF-S1 and CAF-S4, accumulate in LN and correlate with cancer cell invasion. By developing functional assays on primary cultures, we demonstrate that these subsets promote metastasis through distinct functions. While CAF-S1 stimulate cancer cell migration and initiate an epithelial-to-mesenchymal transition through CXCL12 and TGFβ pathways, highly contractile CAF-S4 induce cancer cell invasion in 3-dimensions via NOTCH signaling. Patients with high levels of CAFs, particularly CAF-S4, in LN at diagnosis are prone to develop late distant metastases. Our findings suggest that CAF subset accumulation in LN is a prognostic marker, suggesting that CAF subsets could be examined in axillary LN at diagnosis.
- 2Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway
Science (New York, N.Y.) · 2012
📚 275 citations🎯 RCR 6.37Top 5% NIH🔓 Open AccessLire l'abstract Crossref ↓
The Right Move During development, epithelial tissues deform to give rise to functional tissues and organs. How gene expression controls local cell mechanical properties to drive tissue deformation remains poorly understood. Bosveld et al. (p. 724 , published online 12 April) have uncovered how the conserved Fat/Dachsous/Four-jointed signaling pathway controls local mechanical cell properties to generate global tissue contraction in Drosophila epithelial tissue.
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal38
▼
Transversal38
▼- Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex
The Journal of biological chemistry · 2026 · Journal Article
Hsu HC, Bonnet I, Bryk R, Li H
- Evaluation of the post-antibiotic effect against Mycobacterium abscessus by a bioluminescence method
Microbiology spectrum · 2026 · Journal Article
Bonnet I, Bryk R
- Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays
Proceedings of the National Academy of Sciences of the United States of America · 2025 · Journal Article
Ucla P, Lê-Chesnais J, Ver Hulst H, Ju X, et al.
📚 2 cit. - Successful treatment with anakinra for Mycobacterium genavense-related immune reconstitution inflammatory syndrome in a person with AIDS
AIDS (London, England) · 2025 · Journal Article
Villegas F, Brasme L, Bonnet I, Suret PM, et al.
- Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148
Microbiology spectrum · 2025 · Journal Article
Bonnet I, Orgeur M, Brossier F, Sayes F, et al.
📚 3 cit. - Src kinase slows collective rotation of confined epithelial cell monolayers
Soft matter · 2024 · Journal Article
Pricoupenko N, Marsigliesi F, Marcq P, Blanch-Mercader C, et al.
📚 3 cit. - Clinico-biological factors predicting the benefit of the LV5FU2 maintenance strategy as a first-line therapy in patients with metastatic pancreatic cancer
The oncologist · 2024 · Clinical Trial, Phase II
Boisteau E, Dahan L, Williet N, Le Malicot K, et al.
🩺 Clinique - Multiscale model of the different modes of cancer cell invasion
Bioinformatics (Oxford, England) · 2023 · Journal Article
Ruscone M, Montagud A, Chavrier P, Destaing O, et al.
📚 22 cit.🎯 RCR 2.68 - Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril
Developmental cell · 2023 · Journal Article
Baraban M, Gordillo Pi C, Bonnet I, Gilles JF, et al.
📚 7 cit. - Active tuberculosis screening among the displaced population fleeing Ukraine, France, February to October 2022
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023 · Journal Article
Guthmann JP, Fraisse P, Bonnet I, Robert J
📚 15 cit.🎯 RCR 2.52 - Use of a bDMARD or tsDMARD for the management of inflammatory arthritis under checkpoint inhibitors: an observational study
RMD open · 2022 · Observational Study
De La Fuente F, Belkhir R, Henry J, Nguyen CD, et al.
📚 13 cit.🎯 RCR 1.15🩺 Clinique - atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
Emerging infectious diseases · 2022 · Journal Article
Le Ray LF, Aubry A, Sougakoff W, Revest M, et al.
📚 10 cit.🔬→🩺 Translationnel - Outcomes of Patients with Metastatic Castration-Resistant Prostate Cancer According to Somatic Damage DNA Repair Gene Alterations
Current oncology (Toronto, Ont.) · 2022 · Journal Article
Neviere Z, Coquan E, Brachet PE, Meriaux E, et al.
📚 3 cit.🔬→🩺 Translationnel - Intertissue mechanical interactions shape the olfactory circuit in zebrafish
EMBO reports · 2022 · Journal Article
Monnot P, Gangatharan G, Baraban M, Pottin K, et al.
📚 16 cit.🎯 RCR 1.29 - A Comprehensive Evaluation of GeneLEAD VIII DNA Platform Combined to Deeplex Myc-TB(®) Assay to Detect in 8 Days Drug Resistance to 13 Antituberculous Drugs and Transmission of Mycobacterium tuberculosis Complex Directly From Clinical Samples
Frontiers in cellular and infection microbiology · 2021 · Journal Article
Bonnet I, Enouf V, Morel F, Ok V, et al.
📚 22 cit.🎯 RCR 1.73 - Impact of the revised definition of extensively drug-resistant tuberculosis
The European respiratory journal · 2021 · Letter
Veziris N, Bonnet I, Morel F, Guglielmetti L, et al.
📚 11 cit.🔬→🩺 Translationnel - Rapid Molecular Diagnosis of Tuberculosis and Its Resistance to Rifampicin and Isoniazid with Automated MDR/MTB ELITe MGB(®) Assay
Antibiotics (Basel, Switzerland) · 2021 · Journal Article
Ok V, Aubry A, Morel F, Bonnet I, et al.
- A Multitubular Kidney-on-Chip to Decipher Pathophysiological Mechanisms in Renal Cystic Diseases
Frontiers in bioengineering and biotechnology · 2021 · Journal Article
Myram S, Venzac B, Lapin B, Battistella A, et al.
📚 12 cit. - Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage
Journal of cell science · 2021 · Journal Article
Kerjouan A, Boyault C, Oddou C, Hiriart-Bryant E, et al.
📚 11 cit. - Usefulness of point-of-care multiplex PCR to rapidly identify pathogens responsible for ventilator-associated pneumonia and their resistance to antibiotics: an observational study
Critical care (London, England) · 2020 · Journal Article
Luyt CE, Hékimian G, Bonnet I, Bréchot N, et al.
📚 34 cit.🎯 RCR 2.27🩺 Clinique - Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
Nature communications · 2020 · Journal Article
Pelon F, Bourachot B, Kieffer Y, Magagna I, et al.
📚 305 cit.🎯 RCR 12.83🔬→🩺 Translationnel - Erwinia billingiae as Unusual Cause of Septic Arthritis, France, 2017
Emerging infectious diseases · 2019 · Case Reports
Bonnet I, Bozzi B, Fourniols E, Mitrovic S, et al.
📚 8 cit. - Use of non-carbapenem antibiotics to treat severe extended-spectrum β-lactamase-producing Enterobacteriaceae infections in intensive care unit patients
International journal of antimicrobial agents · 2019 · Journal Article
Luyt CE, Faure M, Bonnet I, Besset S, et al.
📚 14 cit. - Collective stresses drive competition between monolayers of normal and Ras-transformed cells
Soft matter · 2019 · Journal Article
Moitrier S, Blanch-Mercader C, Garcia S, Sliogeryte K, et al.
📚 17 cit. - Evaluation of the Vitek MS and the MALDI Biotyper systems for the identification of less commonly isolated but clinically relevant anaerobes and facultative anaerobes
Anaerobe · 2018 · Evaluation Study
Ferrand J, Bonnet I, Alauzet C, Lozniewski A
📚 17 cit.🎯 RCR 1.39 - The impact of psoriasis on professional life: PsoPRO, a French national survey
Journal of the European Academy of Dermatology and Venereology : JEADV · 2018 · Journal Article
Claudepierre P, Lahfa M, Levy P, Barnetche T, et al.
📚 5 cit.🔬→🩺 Translationnel - Correction to: Controlling Confinement and Topology to Study Collective Cell Behaviors
Methods in molecular biology (Clifton, N.J.) · 2018 · Published Erratum
Duclos G, Deforet M, Yevick HG, Cochet-Escartin O, et al.
- Controlling Confinement and Topology to Study Collective Cell Behaviors
Methods in molecular biology (Clifton, N.J.) · 2018 · Journal Article
Duclos G, Deforet M, Yevick HG, Cochet-Escartin O, et al.
📚 3 cit. - Collagen XVIII: A key interfacial component of the skin architecture
Journal of cosmetic science · 2017 · Journal Article
Bonnet I, Jobeili L, Cadau S, Berthélémy N, et al.
📚 5 cit.🩺 Clinique - Feasibility of Capecitabine and Oxaliplatin Combination Chemotherapy Without Central Venous Access Device in Patients With Stage III Colorectal Cancer
Clinical colorectal cancer · 2016 · Journal Article
Lapeyre-Prost A, Hug de Larauze M, Chibaudel B, Garcia ML, et al.
📚 11 cit.🔬→🩺 Translationnel - Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts
Development (Cambridge, England) · 2016 · Journal Article
Bosveld F, Guirao B, Wang Z, Rivière M, et al.
📚 47 cit.🎯 RCR 1.25 - Microtubule-driven nuclear rotations promote meiotic chromosome dynamics
Nature cell biology · 2015 · Journal Article
Christophorou N, Rubin T, Bonnet I, Piolot T, et al.
📚 60 cit.🎯 RCR 1.57 - Architecture and migration of an epithelium on a cylindrical wire
Proceedings of the National Academy of Sciences of the United States of America · 2015 · Journal Article
Yevick HG, Duclos G, Bonnet I, Silberzan P
📚 84 cit.🎯 RCR 2.70 - An in-house assay is superior to Sepsityper for direct matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry identification of yeast species in blood cultures
Journal of clinical microbiology · 2015 · Evaluation Study
Bidart M, Bonnet I, Hennebique A, Kherraf ZE, et al.
📚 25 cit.🎯 RCR 1.25 - Phenotypic variability in ARCA2 and identification of a core ataxic phenotype with slow progression
Orphanet journal of rare diseases · 2013 · Journal Article
Mignot C, Apartis E, Durr A, Marques Lourenço C, et al.
📚 56 cit.🎯 RCR 2.05 - Mechanical state, material properties and continuous description of an epithelial tissue
Journal of the Royal Society, Interface · 2012 · Journal Article
Bonnet I, Marcq P, Bosveld F, Fetler L, et al.
📚 81 cit.🎯 RCR 2.00 - Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway
Science (New York, N.Y.) · 2012 · Journal Article
Bosveld F, Bonnet I, Guirao B, Tlili S, et al.
📚 275 cit.🎯 RCR 6.37 - Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation
Cell · 2011 · Journal Article
Masui O, Bonnet I, Le Baccon P, Brito I, et al.
📚 106 cit.🎯 RCR 1.84
Essai clinique3
▼
Essai clinique3
▼- TALASUR trial: a single arm phase II trial assessing efficacy and safety of TALazoparib and Avelumab as maintenance therapy in platinum-Sensitive metastatic or locally advanced URothelial carcinoma
BMC cancer · 2022 · Clinical Trial, Phase II
Coquan E, Clarisse B, Lequesne J, Brachet PE, et al.
📚 12 cit.🩺 Clinique - CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure
BMC cancer · 2021 · Clinical Trial Protocol
Coquan E, Brachet PE, Licaj I, Leconte A, et al.
📚 3 cit.🩺 Clinique - Gemcitabine plus cisplatin versus chemoradiotherapy in locally advanced biliary tract cancer: Fédération Francophone de Cancérologie Digestive 9902 phase II randomised study
European journal of cancer (Oxford, England : 1990) · 2014 · Clinical Trial, Phase II
Phelip JM, Vendrely V, Rostain F, Subtil F, et al.
📚 46 cit.🎯 RCR 1.78🩺 Clinique
Sjögren3
▼
Sjögren3
▼- Clinical, biological, prognostic characteristics of patients with immune-mediated thrombotic thrombocytopenic purpura and Sjögren's disease
RMD open · 2024 · Journal Article
Luciano J, Gilardin L, Nocturne G, Bouzid R, et al.
📚 1 cit. - Poussée lupique sévère chez un homme de 76 ans suivi pour un syndrome de Gougerot-Sjögren primaire dans les suites d’une infection à COVID-19
Revue du rhumatisme (Ed. francaise : 1993) · 2022 · Journal Article
Roger G, Pavot A, Bonnet I, Ferlicot S, et al.
- Phenotypic switch from non-active primary Sjögren's syndrome to severe systemic Lupus erythematosus after COVID-19 infection in an elderly man
Joint bone spine · 2021 · Letter
Roger G, Pavot A, Bonnet I, Ferlicot S, et al.
📚 1 cit.
Biothérapies non-anti-TNF2
▼
Biothérapies non-anti-TNF2
▼- Efficacy and safety of rituximab in peripheral ulcerative keratitis associated with rheumatoid arthritis
RMD open · 2021 · Journal Article
Bonnet I, Rousseau A, Duraffour P, Pouchot J, et al.
📚 11 cit.🎯 RCR 1.35 - [Medico-economic benefits of subcutaneous formulations of trastuzumab and rituximab in day hospitalisation (SCuBA Study)]
Bulletin du cancer · 2018 · Journal Article
Favier M, Le Goc-Sager F, Vincent-Cantini I, Launay V, et al.
📚 6 cit.🩺 Clinique
Case report / série2
▼
Case report / série2
▼- Clinical Features and Outcome of Multidrug-Resistant Osteoarticular Tuberculosis: A 12-Year Case Series from France
Microorganisms · 2022 · Journal Article
Bonnet I, Haddad E, Guglielmetti L, Bémer P, et al.
- Unusual subdural empyema in a homeless patient diagnosed by molecular approach: a case report
BMC infectious diseases · 2020 · Case Reports
Brin C, Sougakoff W, Bielle F, Abi Jaoude S, et al.
📚 3 cit.
Pharmacovigilance2
▼
Pharmacovigilance2
▼- TALASUR trial: a single arm phase II trial assessing efficacy and safety of TALazoparib and Avelumab as maintenance therapy in platinum-Sensitive metastatic or locally advanced URothelial carcinoma
BMC cancer · 2022 · Clinical Trial, Phase II
Coquan E, Clarisse B, Lequesne J, Brachet PE, et al.
📚 12 cit.🩺 Clinique - CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure
BMC cancer · 2021 · Clinical Trial Protocol
Coquan E, Brachet PE, Licaj I, Leconte A, et al.
📚 3 cit.🩺 Clinique
Épidémiologie & registres1
▼
Épidémiologie & registres1
▼- High prevalence of spa type t571 among methicillin-susceptible Staphylococcus aureus from bacteremic patients in a French University Hospital
PloS one · 2018 · Journal Article
Bonnet I, Millon B, Meugnier H, Vandenesch F, et al.
📚 23 cit.🎯 RCR 1.30
Lupus1
▼
Lupus1
▼- Phenotypic switch from non-active primary Sjögren's syndrome to severe systemic Lupus erythematosus after COVID-19 infection in an elderly man
Joint bone spine · 2021 · Letter
Roger G, Pavot A, Bonnet I, Ferlicot S, et al.
📚 1 cit.
Qualité de vie / PROMs1
▼
Qualité de vie / PROMs1
▼- Quality of life in cancer patients undergoing anticoagulant treatment with LMWH for venous thromboembolism: the QUAVITEC study on behalf of the Groupe Francophone Thrombose et Cancer (GFTC)
Oncotarget · 2018 · Journal Article
Farge D, Cajfinger F, Falvo N, Berremili T, et al.
📚 17 cit.🔬→🩺 Translationnel
Datasets & protocoles partagés
Description of the dual color labeling scheme used in this study
Image2011figshare<b>Copyright information:</b>Taken from "Detection of single DNA molecules by multicolor quantum-dot end-labeling"Nucleic Acids Research 2005;33(11):e98-e98.Published online 20 Jun 2005PMCID:PMC1153714.© The Author 2005.
One-minute long observation of labeled DNA
Image2011figshare<b>Copyright information:</b>Taken from "Detection of single DNA molecules by multicolor quantum-dot end-labeling"Nucleic Acids Research 2005;33(11):e98-e98.Published online 20 Jun 2005PMCID:PMC1153714.© The Author 2005.
Mechanical state, material properties and continuous description of an epithelial tissue
Preprint2012arXivDuring development, epithelial tissues undergo extensive morphogenesis based on coordinated changes of cell shape and position over time. Continuum mechanics describes tissue mechanical state and shape changes in terms o
Description of the dual color labeling scheme used in this study
Image2011figshare<b>Copyright information:</b>Taken from "Detection of single DNA molecules by multicolor quantum-dot end-labeling"Nucleic Acids Research 2005;33(11):e98-e98.Published online 20 Jun 2005PMCID:PMC1153714.© The Author 2005.
One-minute long observation of labeled DNA
Image2011figshare<b>Copyright information:</b>Taken from "Detection of single DNA molecules by multicolor quantum-dot end-labeling"Nucleic Acids Research 2005;33(11):e98-e98.Published online 20 Jun 2005PMCID:PMC1153714.© The Author 2005.
Unusual subdural empyema in a homeless patient diagnosed by molecular approach: a case report
Collection2020figshareAbstract Background We report a case of subdural empyema in a homeless patient caused by Bartonella quintana. B. quintana is a facultative intracellular bacteria for which bacterial growth is fastidious. The molecular bi
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
