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Auteur de référence en rhumatologie
23 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
131.5 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR LINDA DEZISSERT
13 AVENUE DU TRESUM, 74000 ANNECY
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
The Journal of bone and joint surgery. American volume · 1998
Foot & ankle international · 2016
Background: Although a variety of great toe implants have been tried in an attempt to maintain toe motion, the majority have failed with loosening, malalignment/dislocation, implant fragmentation and bone loss. In these cases, salvage to arthrodesis is more complicated and results in shortening of the ray or requires structural bone graft to reestablish length. This prospective study compared the efficacy and safety of this small (8/10 mm) hydrogel implant to the gold standard of a great toe arthrodesis for advanced-stage hallux rigidus. Methods: In this prospective, randomized non-inferiority study, patients from 12 centers in Canada and the United Kingdom were randomized (2:1) to a synthetic cartilage implant or first metatarsophalangeal (MTP) joint arthrodesis. VAS pain scale, validated outcome measures (Foot and Ankle Ability Measure [FAAM] sport scale), great toe active dorsiflexion motion, secondary procedures, radiographic assessment, and safety parameters were evaluated. Analysis was performed using intent-to-treat (ITT) and modified ITT (mITT) methodology. The primary endpoint for the study consisted of a single composite endpoint using the 3 primary study outcomes (pain, function, and safety). The individual subject’s outcome was considered a success if all of the following criteria were met: (1) improvement (decrease) from baseline in VAS pain of ≥30% at 12 months; (2) maintenance of function from baseline in FAAM sports subscore at 12 months; and (3) absence of major safety events at 2 years. The proportion of successes in each group was determined and 1-sided 95% confidence interval for the difference between treatment groups was calculated. Noninferiority of the implant to arthrodesis was considered statistically significant if the 1-sided 95% lower confidence interval was greater than the equivalence limit (<15%). A total of 236 patients were initially enrolled; 17 patients withdrew prior to randomization, 17 patients withdrew after randomization, and 22 were nonrandomized training patients, leaving 152 implant and 50 arthrodesis patients. Standard demographics and baseline outcomes were similar for both groups. Results: VAS pain scores decreased significantly in both the implant and arthrodesis groups from baseline at 12 and 24 months. Similarly, the FAAM sports and activity of daily living subscores improved significantly at 12 and 24 months in both groups. First MTP active dorsiflexion motion improvement was 6.2 degrees (27.3%) after implant placement and was maintained at 24 months. Subsequent secondary surgeries occurred in 17 (11.2%) implant patients (17 procedures) and 6 (12.0%) arthrodesis patients (7 procedures). Fourteen (9.2%) implants were removed and converted to arthrodesis, and 6 (12.0%) arthrodesis patients (7 procedures [14%]) had isolated screws or plate and screw removal. There were no cases of implant fragmentation, wear, or bone loss. When analyzing the ITT and mITT population for the primary composite outcome of VAS pain, function (FAAM sports), and safety, there was statistical equivalence between the implant and arthrodesis groups. Conclusion: A prospective, randomized (2:1), controlled, noninferiority clinical trial was performed to compare the safety and efficacy of a small synthetic cartilage bone implant to first MTP arthrodesis in patients with advanced-stage hallux rigidus. This study showed equivalent pain relief and functional outcomes. The synthetic implant was an excellent alternative to arthrodesis in patients who wished to maintain first MTP motion. The percentage of secondary surgical procedures was similar between groups. Less than 10% of the implant group required revision to arthrodesis at 2 years. Level of Evidence: Level I, prospective randomized study.
Foot & ankle international · 2006
Background: Charcot arthropathy is a chronic, progressive destructive process affecting bone architecture and joint alignment in people lacking protective sensation. The etiologic factors leading to progressive bone resorption have not been elucidated. The purpose of this study was to histologically examine surgical specimens with Charcot arthropathy for cell type and immunoreactivity of known cytokine mediators of bone resorption. Methods: Tissue samples of 20 specimens with known Charcot arthropathy were stained for Hematoxylin and Eosin (H&E) to quantify cell type. Nine of the specimens were stained with interleukin-1 (IL-1) antibody, nine with tumor necrosis factor (TNF) alpha antibody, and nine with interleukin-6 (IL-6) antibody. Distribution of staining was graded as focal (less than 10% of cells), moderate (10% to 50% of cells), and diffuse (more than 50% of cells) by two independent investigators. Inflammatory cells in tissue sections of rheumatoid synovium served as a positive control. Results: Osteoclasts were seen in excessive numbers lining the resorptive bone lacunae. There was a disproportionate increase in osteoclasts to osteoblasts in the Charcot-reactive bone. In each case, osteoclasts demonstrated immunoreactivity for IL-1, IL-6 and TNF-alpha with a grade of moderate or diffuse reactivity. Conclusion: The findings of excessive osteoclastic activity in the environment of cytokine mediators of bone resorption (IL-1, IL-6, and TNF-alpha) suggest enhanced bone resorption through the stimulation of osteoclastic progenitor cells as well as mature osteoclasts. Alteration in the synthesis, secretion, or activity of these important regulatory molecules through the use of pharmacologic agents may, in turn, alter bone remodeling and loss and lead to accelerated healing without collapse or malalignment.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Foot & ankle orthopaedics · 2022 · Journal Article
Kim JS, Amendola A, Barg A, Baumhauer J, et al.
Foot & ankle international · 2021 · Journal Article
Joo PY, Baumhauer JF, Waldman O, Hoffman S, et al.
Foot & ankle international · 2019 · Clinical Trial
Glazebrook M, Blundell CM, O'Dowd D, Singh D, et al.
The Orthopedic clinics of North America · 2019 · Journal Article
Baumhauer JF, Daniels T, Glazebrook M
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons · 2018 · Journal Article
Glazebrook M, Younger ASE, Daniels TR, Singh D, et al.
Foot & ankle international · 2017 · Comparative Study
Baumhauer JF, Singh D, Glazebrook M, Blundell CM, et al.
The Journal of bone and joint surgery. American volume · 2016 · Journal Article
DiGiovanni CW, Lin SS, Daniels TR, Glazebrook M, et al.
Foot & ankle international · 2014 · Journal Article
Hunt KJ, Alexander I, Baumhauer J, Brodsky J, et al.
Osteoarthritis and cartilage · 2011 · Journal Article
Rao S, Baumhauer JF, Nawoczenski DA
Archives of physical medicine and rehabilitation · 2010 · Journal Article
Rao S, Baumhauer JF, Tome J, Nawoczenski DA
Foot & ankle international · 2009 · Journal Article
Khosla S, Thiele R, Baumhauer JF
Foot & ankle international · 2006 · Journal Article
Baumhauer JF, O'Keefe RJ, Schon LC, Pinzur MS
Foot and ankle clinics · 2003 · Journal Article
Baumhauer JF, DiGiovanni BF
Foot and ankle clinics · 2002 · Case Reports
Baumhauer JF, Lu AP, DiGiovanni BF
The Journal of bone and joint surgery. American volume · 1998 · Journal Article
Shereff MJ, Baumhauer JF
Foot & ankle orthopaedics · 2023 · Journal Article
Anderson MR, Ho BS, Baumhauer JF
Orthopedics · 2017 · Journal Article
Hedgecock J, Cook PC, Harrast J, Baumhauer JF, et al.
Foot & ankle international · 2010 · Journal Article
Patel A, Puzas E, Baumhauer J
Orthopedics · 2017 · Journal Article
Hedgecock J, Cook PC, Harrast J, Baumhauer JF, et al.
Clinical orthopaedics and related research · 2014 · Journal Article
Mann T, Baumhauer JF, O'Keefe RJ, Harrast J, et al.
The Journal of orthopaedic and sports physical therapy · 2009 · Comparative Study
Rao S, Baumhauer JF, Becica L, Nawoczenski DA
Foot & ankle international · 2016 · Comparative Study
Baumhauer JF, Singh D, Glazebrook M, Blundell C, et al.
Journal of the Medical Association of the State of Alabama · 1946 · Journal Article
BAUMHAUER JH
Foot & ankle international · 2016 · Comparative Study
Baumhauer JF, Singh D, Glazebrook M, Blundell C, et al.
The American journal of sports medicine · 2019 · Journal Article
Kenney RJ, Houck J, Giordano BD, Baumhauer JF, et al.