📇 Rhumatologue · MULHOUSE · (68) · Libéral

M Marc BAUMANN

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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
110.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 MULHOUSE (68)LibéralRPPS 10002445848

🇫🇷 Publications académiques françaises (1)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

Brukin2D': a 2D visualization and comparison tool for LC-MS data
2009
ArticleBMC Bioinformatics

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU)

The Knee · 2016

📚 139 citations🎯 RCR 7.57Top 4% NIH🩺 Clinique

Maternal cholestasis during pregnancy programs metabolic disease in offspring

The Journal of clinical investigation · 2013

📚 110 citations🎯 RCR 3.88Top 11% NIH🔓 Open Access📄 PDF gratuit ↗

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

Acta neuropathologica communications · 2013

📚 39 citations🎯 RCR 1.17🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractBackgroundThe Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here we report the special character of Arctic AD neuropathology in four deceased patients.ResultsAβ deposition in the brains was wide-spread (Thal phase 5) and profuse. Virtually all parenchymal deposits were composed of non-fibrillar, Congo red negative Aβ aggregates. Congo red only stained angiopathic vessels. Mass spectrometric analyses showed that Aβ deposits contained variably truncated and modified wild type and mutated Aβ species. In three of four Arctic AD brains, most cerebral cortical plaques appeared targetoid with centres containing C-terminally (beyond aa 40) and variably N-terminally truncated Aβ surrounded by coronas immunopositive for Aβx-42. In the fourth patient plaque centres contained almost no Aβ making the plaques ring-shaped. The architectural pattern of plaques also varied between different anatomic regions. Tau pathology corresponded to Braak stage VI, and appeared mainly as delicate neuropil threads (NT) enriched within Aβ plaques. Dystrophic neurites were scarce, while neurofibrillary tangles were relatively common. Neuronal perikarya within the Aβ plaques appeared relatively intact.ConclusionsIn Arctic AD brain differentially truncated abundant Aβ is deposited in plaques of variable numbers and shapes in different regions of the brain (including exceptional targetoid plaques in neocortex). The extracellular non-fibrillar Aβ does not seem to cause overt damage to adjacent neurons or to induce formation of neurofibrillary tangles, supporting the view that intracellular Aβ oligomers are more neurotoxic than extracellular Aβ deposits. However, the enrichment of NTs within plaques suggests some degree of intra-plaque axonal damage including accumulation of hp-tau, which may impair axoplasmic transport, and thereby contribute to synaptic loss. Finally, similarly as the cotton wool plaques in AD resulting from exon 9 deletion in the presenilin-1 gene, the Arctic plaques induced only modest glial and inflammatory tissue reaction.

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M Marc BAUMANN

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Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (20) — classées par pathologie

Transversal12

Recommandations2

AINS1

Épidémiologie & registres1

Essai clinique1

Fibromyalgie1

Ostéoporose1

Pédiatrie1

Revue générale1

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