Docteur ATHAN BAILLET

Thèses universitaires

• Régulation de l'activité de la NADPH oxydase des neutrophiles par des enzymes du métabolisme du glucose et l'hétérocomplexe S100A8/S100A9 : application à la polyarthrite rhumatoïde

  2011

  Regulation of phagocyte NADPH oxydase activity by enzymes regulating glucose metabolism and S100A8/S100A9 heterocomplex : application to rheumatoid arthritis

  Biologie cellulaire🎓 Grenoble

  Direction : Françoise Morel, Philippe Gaudin

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

• Etude des mécanismes pathogéniques impliquant l’immunité innée dans les spondyloarthrites

  2022

  Doctorant·e : Xavier Romand

  Virologie microbiologie immunologie🎓 Université Grenoble Alpes

• Exploration de l'interaction entre activité physique et sommeil dans les rhumatismes inflammatoires chroniques : effets d'une intervention combinée

  Doctorant·e : Nathan Aymard

  Physiologie-Physiopathogies-Pharmacologie🎓 Université Grenoble Alpes

Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).

Bibliographie

• Erratum à « Actualisation 2024 des recommandations de la Société française de rhumatologie pour le diagnostic et la prise en charge des personnes souffrant de polyarthrite rhumatoïde » [Rev. Rhum. 2024;91 (6):663–93]

  2025

  ArticleRevue du Rhumatisme

• When generative artificial intelligence answers to Google Trends about spondyloarthritis: what does a French expert panel think about it?

  2025

  ArticleRMD Open : Rheumatic & Musculoskeletal Diseases

• A systematic standardized global assessment of chronic inflammatory rheumatism: Benefits and limitations

  2025

  ArticleRevue du Rhumatisme

• Unmet needs in axial spondyloarthritis. Proceedings of the French spondyloarthritis taskforce workshop

  2024

  ArticleJoint Bone Spine

• Gender influences adhesion to recommendations for optimal comorbidity screening and management of patients with chronic inflammatory rheumatic diseases starting a biological disease-modifying antirheumatic drug

  2024

  ArticleRMD Open

• Actualisation 2024 des recommandations de la Société Française de Rhumatologie pour le diagnostic et la prise en charge des personnes souffrant de polyarthrite rhumatoïde

  2024

  ArticleRevue du Rhumatisme

• 2024 update of the recommendations of the French Society of Rheumatology for the diagnosis and management of patients with rheumatoid arthritis

  2024

  ArticleJoint Bone Spine

• Standardized reporting for systematic global evaluation of axial spondyloarthritis: An evidence-based and consensus-driven initiative

  2024

  ArticleJoint Bone Spine

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieu de consultation

• HOPITAL SUD - CHU38

  Avenue DE KIMBERLEY, 38130 Échirolles

  ☎ 0476767575Hospitalier🏥 Voir cet établissement
  © OpenStreetMap

  📷 Street View ↗🗺️ Maps ↗OSM ↗

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial

  Annals of the rheumatic diseases · 2021

  📚 93 citations🎯 RCR 7.65Top 4% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗
• 2

  Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review

  Journal of clinical medicine · 2020

  📚 17 citations🎯 RCR 1.30🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Objectives. Central neurological manifestations of rheumatoid arthritis (RA) like rheumatoid meningitis (RM) are rare, little known and have a high rate of morbi-mortality. METHODS. We described six cases of RM that were directly related to RA activity after exhaustive assessment. RESULTS. They were mainly women, aged of 50 to 69. All were positive for anti-cyclic citrullinated peptide antibodies and half for rheumatoid factors. RA activity, duration, and treatments were heterogeneous including oral steroids, conventional synthetic disease modifying anti-rheumatic drugs (DMARDs) and biologic DMARDs. Symptoms were various, with acute or progressive beginning; main were: generalized or focal seizure (4/6), fever (3/6), headaches (3/6), and frontal syndrome (2/6). Imaging lesions were four leptomeningitis, one pachymeningitis, and one association of both. MRI usually showed hypersignal in various territories in T2-FLAIR (fluid attenuated inversion recovery) mode, and enhancement in T1-weighted mode after gadolinium injection. All patients had lumbar puncture that found sterile cerebrospinal fluid, no neoplasic cell, elevated cell count in 5/6 cases and elevated proteins concentration in 3/6 cases. Cerebral biopsy was possible for three patients, and definitively confirmed the diagnosis of aseptic lepto- or pachymenintis, excluding vasculitis and lymphoma. Different treatments were used like intravenous high dose steroids, immunoglobulins or biologic DMARDs, with variable clinical and imaging outcome: one death, one complete recovery, and four recoveries with sequelae. Conclusions. Clinical symptoms, imaging, lumbar puncture, and serological studies are often nonspecific, only histologic examination can confirm the diagnosis of RM. Any central neurological manifestation in RA patients, even in quiescent and ancient RA, should warn the physician.

• 3

  Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice

  Arthritis & rheumatology (Hoboken, N.J.) · 2021

  📚 13 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  ObjectiveZAP‐70W163C BALB/c (SKG) mice develop reactive arthritis (ReA) following infection with Chlamydia muridarum. Since intracellular pathogens enhance their replicative fitness in stressed host cells, we examined how myeloid cells infected with C muridarum drive arthritis.MethodsSKG, Il17a‐deficient SKG, and BALB/c female mice were infected with C muridarum or C muridarum luciferase in the genitals. C muridarum dissemination was assessed by in vivo imaging or genomic DNA amplification. Macrophages were depleted using clodronate liposomes. Anti–tumor necrosis factor (anti‐TNF) and anti–interleukin‐23p19 (anti–IL‐23p19) were administered after infection or arthritis onset. Gene expression of Hspa5, Tgtp1, Il23a, Il17a, Il12b, and Tnf was compared in SKG mice and BALB/c mice.ResultsOne week following infection with C muridarum, macrophages and neutrophils were observed to have infiltrated the uteri of mice and were also shown to have carried C muridarum DNA to the spleen. C muridarum load was higher in SKG mice than in BALB/c mice. Macrophage depletion was shown to reduce C muridarum load and prevent development of arthritis. Compared with BALB/c mice, expression of Il23a and Il17a was increased in the uterine and splenic neutrophils of SKG mice. The presence of anti–IL‐23p19 during infection or Il17a deficiency suppressed arthritis. Tnf was overexpressed in the joints of SKG mice within 1 week postinfection, and persisted beyond the first week. TNF inhibition during infection or at arthritis onset suppressed the development of arthritis. Levels of endoplasmic reticulum stress were constitutively increased in the joints of SKG mice but were induced, in conjunction with immunity‐related GTPase, by C muridarum infection in the uterus.ConclusionC muridarum load is higher in SKG mice than in BALB/c mice. Whereas proinflammatory IL‐23 produced by neutrophils contributes to the initiation of C muridarum–mediated ReA, macrophage depletion reduces C muridarum dissemination to other tissues, tissue burden, and the development of arthritis. TNF inhibition was also shown to suppress arthritis development. Our data suggest that enhanced bacterial dissemination in macrophages of SKG mice drives the TNF production needed for persistent arthritis.

Publications scientifiques (50) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice

  Dataset2022The University of Queensland

  Supplementary data for the article High Chlamydia burden promotes TNF-dependent reactive arthritis in SKG mice published in the journal ARTHRITIS & RHEUMATOLOGY Vol. 67, No. 6, June 2015, pp 1535–1547.  See the link in t

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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