Docteur Jean Pierre ARNAL
Diplômes
🎓 DES & spécialité ordinale
- Rhumatologie (SM)
📚 CES (Certificat d'Études Spéciales)
- CES Rhumatologie
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Direction de thèses
🎓 1 thèse dirigéeSource theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Lieu de consultation
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells
Blood · 2005
Lire l'abstract Crossref ↓
AbstractMechanisms accounting for gender dimorphism during immune responses are still poorly understood. Since invariant natural killer T (iNKT) cells exert important regulatory functions through their capacity to produce both T helper 1 (Th1) and Th2 cytokines, we addressed the question of whether these activities could be modulated by sexual hormones. We found that in vivo challenge with the specific ligand of iNKT cells, α-galactosylceramide (α-GalCer), induced significantly higher concentrations of interferon γ (IFN-γ) in the serum of female than in that of male mice, while interleukin 4 (IL-4) production was not modified. In support of a crucial role of ovarian hormones in this phenomenon, a significant decrease of serum IFN-γ concentrations occurred in ovariectomized females, in response to treatment with α-GalCer, while orchidectomy affected neither IFN-γ nor IL-4 serum concentrations in males. The implication of estrogens in this selective enhancement of IFN-γ production by iNKT cells was demonstrated by (1) the increased α-GalCer–induced IFN-γ synthesis by iNKT cells upon both in vitro and in vivo exposure to estradiol and (2) the abolition of the sex-linked difference in α-GalCer–induced IFN-γ release in estrogen receptor α-deficient mice. These results provide the first evidence that estrogens influence iNKT cells leading to this gender dimorphism in their cytokine production profile.
- 2Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice
Atherosclerosis · 2001
📚 103 citations🎯 RCR 2.03 - 3Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo
Steroids · 2013
📚 37 citations🎯 RCR 1.16
Publications scientifiques (13) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal13
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Transversal13
▼- Effects of conjugated estrogen and bazedoxifene on hemostasis and thrombosis in mice
Endocrine connections · 2019 · Journal Article
Noirrit E, Buscato M, Dupuis M, Payrastre B, et al.
📚 1 cit. - From the Women's Health Initiative to the combination of estrogen and selective estrogen receptor modulators to avoid progestin addition
Maturitas · 2015 · Journal Article
Valera MC, Gourdy P, Trémollières F, Arnal JF
📚 13 cit.🔬→🩺 Translationnel - [Association of estrogens and selective estrogens receptors modulators: towards a renewal of the hormonal treatment?]
Presse medicale (Paris, France : 1983) · 2015 · English Abstract
Valéra MC, Chantalat E, Vinel A, Benoit T, et al.
- The transcriptional activities and cellular localization of the human estrogen receptor alpha are affected by the synonymous Ala87 mutation
The Journal of steroid biochemistry and molecular biology · 2014 · Journal Article
Fernández-Calero T, Astrada S, Alberti A, Horjales S, et al.
📚 11 cit. - Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo
Steroids · 2013 · Journal Article
Arnal JF, Fontaine C, Abot A, Valera MC, et al.
📚 37 cit.🎯 RCR 1.16 - In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives
Annales d'endocrinologie · 2013 · Journal Article
Arnal JF, Gourdy P, Lenfant F
📚 8 cit. - Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models
Thrombosis research · 2012 · Journal Article
Arnal JF, Valéra MC, Payrastre B, Lenfant F, et al.
📚 13 cit. - From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause
British journal of pharmacology · 2012 · Journal Article
Arnal JF, Lenfant F, Flouriot G, Tremollières F, et al.
📚 11 cit. - Association of neutrophil count with microembolization in patients with symptomatic carotid artery stenosis
Atherosclerosis · 2009 · Journal Article
Nasr N, Ruidavets JB, Arnal JF, Sie P, et al.
📚 32 cit.🔬→🩺 Translationnel - High frequency of endothelial vasomotor dysfunction after acute coronary syndromes in non-culprit and angiographically normal coronary arteries: a reversible phenomenon
Atherosclerosis · 2005 · Journal Article
Elbaz M, Carrié D, Baudeux JL, Arnal JF, et al.
📚 19 cit.🔬→🩺 Translationnel - Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells
Blood · 2005 · Journal Article
Gourdy P, Araujo LM, Zhu R, Garmy-Susini B, et al.
📚 116 cit.🎯 RCR 2.57 - Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice
Atherosclerosis · 2001 · Comparative Study
Elhage R, Clamens S, Besnard S, Mallat Z, et al.
📚 103 cit.🎯 RCR 2.03🔬→🩺 Translationnel - [Invasive Streptococcus agalactiae infections at a general university hospital over a 10-year period]
Enfermedades infecciosas y microbiologia clinica · 1996 · English Abstract
Giménez M, Sopena N, Viñado B, Cardona PJ, et al.
📚 1 cit.