📇 Rhumatologue · BOBIGNY CEDEX · (93) · Hospitalier

MME MARIE-HELENE ANDRE

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3 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
29 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
78.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 BOBIGNY CEDEX (93)HospitalierRPPS 10001424083

3 publications sur 5 ans

📊 Reconnaissance scientifique : 1/100📝 3 articles publiés🇫🇷 Publications académiques françaises (4)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Reactive hemophagocytic syndrome in adult systemic disease: report of twenty-six cases and literature review

Arthritis and rheumatism · 2003

📚 229 citations🎯 RCR 6.88Top 5% NIH

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AbstractObjectiveTo analyze specific clinical findings, underlying disorders, treatments, outcomes, and prognostic factors for reactive hemophagocytic syndrome (RHS) in systemic disease.MethodsData were collected using standardized forms as part of a French national survey. Adult cases without an underlying malignancy, diagnosed on bone marrow or lymph node biopsy, were included.ResultsTwenty‐six cases (7 men, 19 women, mean age 47.4 ± 17.7 years) were studied. Systemic diseases included systemic lupus erythematosus (n = 14), rheumatoid arthritis (n = 2), adult onset systemic Still's disease (n = 4), polyarteritis nodosa (n = 2), mixed connective tissue disease (n = 1), pulmonary sarcoidosis (n = 1), systemic sclerosis (n = 1), and Sjögren's syndrome (n = 1). RHS occurred in 2 distinct clinical settings in the course of systemic disease. RHS was associated with an active infection in 15 patients (bacterial infections, 10 cases; viral, 3 cases; tuberculosis, 1 case; and aspergillosis, 1 case) and with the onset of a systemic disease alone in 9 cases. Isolated RHS occurred in 2 cases. The overall mortality rate was 38.5%. Two factors were associated with mortality: corticosteroid treatment at the time of RHS diagnosis, and thrombocytopenia (odds ratio = 28, 95% confidence interval = 13.3−238.9).ConclusionsWhen RHS occurs in the course of an active systemic disease (situation only reported in cases of systemic lupus or adult Still's disease), immunosuppressive therapy should be used. In contrast, when RHS is present concomitantly with an active infection, immunosuppressive therapy needs to be lowered and antibiotic therapy should be instituted.

Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients

Arthritis and rheumatism · 2007

📚 192 citations🎯 RCR 5.55Top 7% NIH🩺 Clinique

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AbstractObjectiveTo compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg‐Strauss syndrome (CSS).MethodsIn this prospective multicenter therapeutic trial, 48 patients with CSS with at least 1 poor‐prognosis factor at baseline were treated with glucocorticoids and either 12 or 6 intravenous cyclophosphamide pulses.ResultsAt 8 years, complete remission rates and severe side effects of therapy were comparable for both groups. The overall difference in relapses was not significant between the 12‐pulse and the 6‐pulse regimens (P= 0.07), but when considering only the number of mild relapses this difference became statistically significant (P< 0.02). Although the total number of inclusions was not reached, the study was stopped prematurely in response to the superiority of the 12‐pulse regimen.ConclusionWe concluded that 12 cyclophosphamide pulses were better able to control severe CSS than a 6‐pulse regimen. The optimal duration of therapy remains to be determined.

Risk factors and prognostic influence of infection in a single cohort of 87 adults with systemic lupus erythematosus

Annals of the rheumatic diseases · 2001

📚 139 citations🎯 RCR 4.20Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

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MME MARIE-HELENE ANDRE

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (29) — classées par pathologie

Vascularites7

Transversal4

Biothérapies non-anti-TNF3

Case report / série3

Arthrite juvénile2

Lupus2

Revue générale2

Anti-TNF1

Gériatrie1

Maladie à IgG41

Pédiatrie1

Santé mentale / fatigue1

SAPL1

Sclérodermie1

Vascularites des gros vaisseaux1

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