📇 Rhumatologue · FORT DE FRANCE CEDEX · (972) · Hospitalier
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3 raisons identifiées
Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Praticien-chercheur
12 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
106.4 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CHU DE MARTINIQUE SITE P.ZOBDA QUITMAN
QUA LA MEYNARD CS 90632, 97261 FORT DE FRANCE CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Journal of cutaneous pathology · 2011
Journal of cutaneous pathology · 2008
We report a 2‐year‐old girl with developmental delay who, from the age of 1 year, developed perniotic lesions of the hands and feet initially diagnosed as chilblain lupus. Histological examination showed features of epidermal necrosis with intraepidermal bulla formation, interface dermatitis, lymphocytic vasculitis with fibrinoid necrosis and thrombi formation, both superficial and deep dermal lymphocytic infiltrate, lymphocytic eccrine hidradenitis and absence of marked dermal edema. Subsequent investigations suggested a clinical diagnosis of Aicardi–Goutières syndrome (AGS), a rare genetic leukoencephalopathy. Recently, both AGS and familial chilblain lupus, an autosomal dominant form of systemic lupus erythematosus (SLE), have been shown to be allelic thus suggesting a common pathogenic basis. In addition, a phenotypic overlap is apparent between SLE and AGS. To our knowledge, this is the first comprehensive dermatopathological report of the cutaneous lesions seen in AGS, and our paper highlights the importance of considering AGS in the differential diagnosis of perniosis and chilblain lupus.
Lupus · 2007
Genetic determinants taking part in the development of systemic lupus erythematosus (SLE) are complex and not fully characterized. Dysregulated expression of genes involved in the control of apoptosis has been previously suggested. We report here a consanguineous family with SLE manifestations in three siblings associated in one of them with severe lymphoproliferative features. Laboratory studies showed no defect in CD95-mediated cell death. Screening expression of Bcl-2 family genes that regulate mitochondrial apoptosis pathway showed an overexpression of the antiapoptotic Bfl-1 gene. Real time RT-PCR analysis indicated that overexpression of Bfl-1 was restricted to B-cells, with normal expression in T-cells. Those results suggest that overexpression of Bfl-1 could result in impaired B-lymphocyte homeostasis and inappropriate immune response leading to autoimmune manifestations.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of cutaneous pathology · 2008 · Case Reports
Kolivras A, Aeby A, Crow YJ, Rice GI, et al.
Dermatologica · 1985 · Case Reports
Piette-Brion B, de Bast C, Chamoun E, de Dobbeleer G, et al.
Revue du rhumatisme et des maladies osteo-articulaires · 1963 · Journal Article
ARLET J, ANDRE J, DUNGLAS J, VIDAL R
Transplantation proceedings · 2020 · Case Reports
Renaud-Picard B, Gallais F, Ohana M, Zeyons F, et al.
Journal of cutaneous pathology · 2015 · Case Reports
Kolivras A, Thompson C, Metz T, André J
Lupus · 2007 · Case Reports
Andre J, Cimaz R, Ranchin B, Galambrun C, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2004 · Case Reports
Richert B, André J, Bourguignon R, de la Brassinne M
Journal of cutaneous pathology · 2011 · Case Reports
Kolivras A, Theunis A, Ferster A, Lipsker D, et al.
Clinical and experimental dermatology · 1998 · Case Reports
Vanhooteghem O, Andre J, Pochet JM, Demaubeuge J, et al.
Clinical biomechanics (Bristol, Avon) · 2003 · Clinical Trial
Beyaert C, Haumont T, Paysant J, Lascombes P, et al.
Journal de genetique humaine · 1973 · Journal Article
Kissel P, André JM, André M
Journal of the European Academy of Dermatology and Venereology : JEADV · 2007 · Case Reports
Delplace D, da Costa LM, Goffin L, Wechsler ME, et al.