Docteur CHLOE ALLARD

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Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• VIDEO. Santé : le dispositif Asalée en danger ? - Ouest-France

  📰 Ouest-France · 14/03/2024

  <a href="https://news.google.com/rss/articles/CBMi0wFBVV95cUxQcUJUUWhWQ2stQ1MxMXJBNGxVX0c2Q2dCRkl5RjBjV1B2eFFnNHdTRENyeHl1RVhybGFSbFRXVGJoeXFpdUhORXZJYlFWZHFrd2hsVlJvcFhzbkhpM2RFMmlSVlVHSmp5eG9tSlh3YWlYVVJfcXRTQXJwYkhaczh3UTBCZFVvZjRVbEdHWm8zZjVkTjRRMXJGZ2RUMW5PYkdsNHB0alNPbWl2ak81WWJNaFlEY0RpdGdHS2

Top publications · les plus citées

• 1

  Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans

  Journal of immunology (Baltimore, Md. : 1950) · 2011

  📚 106 citations🎯 RCR 2.61Top 19% NIH

  Lire l'abstract Crossref ↓

  Abstract The mechanism whereby IL-17 drives rheumatoid arthritis remains incompletely understood. We demonstrate that anti–IL-17 therapy in collagen-induced arthritis ameliorates bone damage by reducing the number of osteoclasts in joints. We found equal numbers of CD4+ Th17 and IL-17 producing γδ T cells in the joints of arthritic mice, and in vitro, both populations similarly induced osteoclastogenesis. However, individual depletion and adoptive transfer studies revealed that in vivo, Th17 cells dominated with regard to bone destruction. Unlike γδ T cells, Th17 cells were found in apposition to tartrate-resistant acid phosphatase positive osteoclasts in subchondral areas of inflamed joints, a pattern reproduced in patient biopsies. This localization was caused by Ag-specific retention, because OVA-primed Th17 cells showed a γδ T cell-like diffuse distribution. Because IL-23, as produced by osteoclasts, enhanced T cell-mediated osteoclastogenesis, we propose that Ag-specific juxtaposition is key to foster the molecular cross talk of Th17 cells and osteoclasts, thus driving arthritic bone destruction.

• 2

  Disc space narrowing as a new risk factor for vertebral fracture: the OFELY study

  Arthritis and rheumatism · 2006

  📚 32 citations🎯 RCR 1.29

  Lire l'abstract Crossref ↓

  AbstractObjectiveIn a previous cross‐sectional analysis, we found a positive association between disc space narrowing (DSN) and vertebral fracture. The aim of the present study was to analyze prospectively the risk of vertebral and nonvertebral fractures in women with spine osteoarthritis (OA).MethodsUsing radiographs, spine OA was evaluated in 634 postmenopausal women from the OFELY (Os des Femmes de Lyon) cohort (mean ± SD age 61.2 ± 9 years). Prevalence and severity of spine OA were assessed by scoring osteophytes and DSN. Incidental clinical fractures were prospectively registered during annual followup, and vertebral fractures were evaluated by radiography every 4 years.ResultsDuring an 11‐year followup, fractures occurred in 121 women, including 42 with vertebral fractures. No association was found between osteophytes and the risk of fracture. In contrast, DSN was associated with an increased risk of vertebral fractures but not of nonvertebral fractures. After adjusting for confounding variables, the presence of DSN was associated with a marked increased risk of vertebral fractures, with an odds ratio of 6.59 (95% confidence interval 1.36–31.9). In addition, 95% of incident vertebral fractures were located above the disc with the most severe narrowing.ConclusionThis longitudinal study shows that, despite a higher bone mineral density (BMD), women with spine OA do not have a reduced risk of fracture and that DSN is significantly associated with vertebral fracture risk. The location of DSN and of incident vertebral fractures suggests that disc degeneration impairs the biomechanics of the above spine, which leads to the increased risk of vertebral fractures, independent of BMD. We suggest that DSN is a newly identified risk factor for vertebral fracture that should be taken into consideration when assessing vertebral fracture risk in postmenopausal women.

• 3

  [Treatment of Felty's syndrome with lithium]

  La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1976

  📚 7 citations

Publications scientifiques (5) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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