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M Duc-Hung TRAN

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Auteur de référence en rhumatologie
22 articles scientifiques publiés — un praticien à la pointe de la recherche

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The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids

Arthritis and rheumatism · 2005

📚 105 citations🎯 RCR 3.55Top 13% NIH🩺 Clinique

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AbstractObjectiveChildhood dermatomyositis (DM) is often a chronic disease, lasting many years. It has traditionally been treated with long‐term corticosteroid therapy; side effects are often seen. For more than a decade, methotrexate (MTX) has been safely used for the treatment of juvenile arthritis. Here, we report use of MTX as first‐line therapy for DM, along with aggressively tapered corticosteroids, in an attempt to reduce treatment‐related side effects.MethodsWe studied an inception cohort of 31 children with DM who were rigorously followed up in our myositis clinic, and compared them with a control group of 22 patients with incident cases of juvenile DM who received treatment just before we instituted a policy of first‐line therapy with MTX. The mean starting dosage of MTX in the study group was 15 mg/m2/week.ResultsBoth groups had similar improvement in strength and physical function; however, the median time during which patients in the study group received corticosteroids was 10 months, compared with 27 months for controls (P < 0.0001). As a result, the cumulative prednisone dose in the study group was approximately half that in the control group (7,574 mg versus 15,152 mg; P = 0.0006). The study group had greater height velocity during the first year of treatment and a smaller increase in the body mass index over the first 2 years. In the control group, the relative risk of cataracts developing was 1.95 (95% confidence interval 1.05–4.17). Side effects of MTX were rarely observed.ConclusionUse of MTX in conjunction with an aggressively tapered course of prednisone may be as effective as traditional long‐term corticosteroid therapy for children with DM, while decreasing the cumulative dose of corticosteroids.

Survival of Dental Implants Placed in Grafted and Nongrafted Bone: A Retrospective Study in a University Setting

The International journal of oral & maxillofacial implants · 2016

📚 50 citations🎯 RCR 3.67Top 12% NIH

Self-reported health, functional status and chronic disease in community dwelling older adults: untangling the role of demographics

Journal of community health · 2010

📚 38 citations🎯 RCR 1.68

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M Duc-Hung TRAN

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Publications scientifiques (22) — classées par pathologie

Transversal14

Case report / série1

csDMARDs1

Épidémiologie & registres1

Génétique1

Gériatrie1

Pharmacovigilance1

Revue / méta-analyse1

Revue générale1

Sjögren1

Vascularites des gros vaisseaux1

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