📇 Rhumatologue ·
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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
International journal of molecular medicine · 2016
Bone research · 2024
Abstract Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to fracture and on the immunomodulation of skeletal stem/progenitor cells (SSPCs) remains unknown. Here, we used single-nucleus transcriptomic analyses to describe the immune cell dynamics after bone fracture and identified distinct macrophage subsets with successive pro-inflammatory, pro-repair and anti-inflammatory profiles. Concurrently, SSPCs transition via a pro- and anti-inflammatory fibrogenic phase of differentiation prior to osteochondrogenic differentiation. In a preclinical MTI mouse model, the injury response of immune cells and SSPCs is disrupted leading to a prolonged pro-inflammatory phase and delayed resolution of inflammation. Macrophage depletion improves bone regeneration in MTI demonstrating macrophage involvement in fibrous nonunion. Finally, pharmacological inhibition of macrophages using the CSF1R inhibitor Pexidartinib ameliorates healing. These findings reveal the coordinated immune response of macrophages and skeletal stem/progenitor cells as a driver of bone healing and as a primary target for the treatment of trauma-associated fibrosis.
eLife · 2024
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly understood. Here, we generated a single-nucleus atlas of the periosteum at steady state and of the fracture site during the early stages of bone repair (https://fracture-repair-atlas.cells.ucsc.edu). We identified periosteal SSPCs expressing stemness markers (Pi16 and Ly6a/SCA1) and responding to fracture by adopting an injury-induced fibrogenic cell (IIFC) fate, prior to undergoing osteogenesis or chondrogenesis. We identified distinct gene cores associated with IIFCs and their engagement into osteogenesis and chondrogenesis involving Notch, Wnt, and the circadian clock signaling, respectively. Finally, we show that IIFCs are the main source of paracrine signals in the fracture environment, suggesting a crucial paracrine role of this transient IIFC population during fracture healing. Overall, our study provides a complete temporal topography of the early stages of fracture healing and the dynamic response of periosteal SSPCs to injury, redefining our knowledge of bone regeneration.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of translational medicine · 2026 · Journal Article
Wang L, Qi H, Zhang Y, Wei G, et al.
Journal of the American Medical Informatics Association : JAMIA · 2026 · Journal Article
E T, Li X, Liang J, Ma J, et al.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025 · Journal Article
G A, C G, C J M, B L, et al.
eLife · 2024 · Journal Article
Perrin S, Ethel M, Bretegnier V, Goachet C, et al.
Rheumatology (Oxford, England) · 2024 · Journal Article
Wang L, Chen S, Zhang H, Wei G, et al.
Bone research · 2024 · Journal Article
Hachemi Y, Perrin S, Ethel M, Julien A, et al.
Rheumatology advances in practice · 2023 · Journal Article
Ebrahimiarjestan M, Yang L, E E, Wang T, et al.
Heliyon · 2023 · Journal Article
Zheng Y, Deng J, Wang G, Zhang X, et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology] · 2020 · Journal Article
Wang RH, Xu K, Li L, Wu ZF, et al.
Zhongguo gu shang = China journal of orthopaedics and traumatology · 2020 · Journal Article
Yu QB, E ZK, Xin HW, Zhang YS, et al.
International journal of molecular medicine · 2016 · Journal Article
E LL, Xu WH, Feng L, Liu Y, et al.
Ethiopian medical journal · 2015 · Journal Article
Binegdie AB, Parekh M, Tolessa TB, Ahmed FO, et al.
Annals of hematology · 2014 · Journal Article
Hawkes EA, Barton S, Cunningham D, Peckitt C, et al.
Zhonghua nei ke za zhi · 2007 · English Abstract
Li JZ, Liu Y, E J, Huang HC, et al.
Indian journal of medical microbiology · 2006 · Journal Article
Ethel S, Bhat GK, Hegde BM
Chinese medical journal · 1999 · Journal Article
Zhang Y, Geng H, Zhao M, Zou W, et al.
Journal of orthopaedic case reports · 2016 · Case Reports
Ay GR, D SR, T C, C K, et al.
Zhongguo shi yan xue ye xue za zhi · 2019 · Journal Article
Liu YF, He HQ, Ding YL, Wu SY, et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026 · Consensus Statement
Fusaro M, Chandran M, Nickolas T, Ferrari S, et al.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2025 · Journal Article
Ebrahimiarjestan M, O'sullivan M, Brennan A, E E, et al.