📇 Rhumatologue · CAEN CEDEX 4 · (14) · Salarié

M MICHEL ROCA

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18 articles scientifiques publiés — formation continue solide
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150.8 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CAEN CEDEX 4 (14)SalariéRPPS 10002102076

✨ Génération du profil synthétique IA en cours…

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AGENCE REGIONALE DE SANTE DE NORMANDIE
ESPACE CLAUDE MONET ARS DE NORMANDIE 2 PLACE JEAN NOUZILLE CS5035, 14050 CAEN CEDEX 4
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Top publications · les plus citées

Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study

Acta psychiatrica Scandinavica · 2012

📚 60 citations🎯 RCR 2.49Top 21% NIH

Lire l'abstract Crossref ↓

Fayed N, Andres E, Rojas G, Moreno S, Serrano‐Blanco A, Roca M, Garcia‐Campayo J. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.Objective: To evaluate the brain metabolite patterns in patients with fibromyalgia (FM) and somatization disorder (STD) compared with healthy controls through spectroscopy techniques and correlate these patterns with psychological variables.Method: Design. Controlled, cross‐sectional study. Sample. Patients were recruited from primary care in Zaragoza, Spain. The control group was recruited from hospital staff. Patients were administered questionnaires on pain catastrophizing, anxiety, depression, pain, quality of life, and cognitive impairment. All patients underwent Magnetic Resonance Imaging and magnetic resonance spectroscopy (MRS).Results: A significant increase was found in the glutamate + glutamine (Glx) levels in the posterior cingulate cortex (PCC): 10.73 (SD: 0.49) for FM and 9.67 (SD: 1.10) for STD 9.54 (SD: 1.46) compared with controls (P = 0.043). In the FM + STD group, a correlation between Glx and pain catastrophizing in PCC (r = 0.397; P = 0.033) and between quality of life and the myo‐inositol/creatine ratio in the left hippocampus (r = −0.500; P = 0.025) was found. To conclude Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H‐MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.Conclusion: Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H‐MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.

Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up

Pain · 2014

📚 59 citations🎯 RCR 2.69Top 19% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Sodium fluoride prevents bone loss in primary biliary cirrhosis

Journal of hepatology · 1992

📚 54 citations🎯 RCR 1.94🩺 Clinique

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M MICHEL ROCA

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Top publications · les plus citées

Publications scientifiques (18) — classées par pathologie

Transversal7

Essai clinique4

Gériatrie3

Vraie vie / RWE3

Épidémiologie & registres1

IRM ostéo-articulaire1

Pharmacovigilance1

Revue générale1

Santé mentale / fatigue1

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