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2 raisons identifiées
Auteur de référence en rhumatologie
33 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
86.1 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR TRIEU HIEP NGUYEN
CABINET MEDICAL PAUL DOUMER 63 AVENUE PAUL DOUMER, 78360 MONTESSON
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Science translational medicine · 2025
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention in at-risk individuals could prevent or delay future tissue damage; however, the immunobiology of this stage is unclear. Using integrative multiomics, we longitudinally profiled at-risk individuals, where one-third of participants developed clinical RA on study. We found evidence of systemic inflammation and signatures of activation in naïve T and B cells of at-risk individuals. During progression to clinical RA, proinflammatory skewing of atypical B cells and expansion of memory CD4 T cells with signatures of activation and B cell help were present without elevations in circulating ACPA titers. Epigenetic changes in naïve CD4 T cells suggested a predisposition to differentiate into effector cells capable of B cell help. These findings characterize pathogenesis of the ACPA + at-risk stage and support the concept that the disease begins much earlier than clinical RA. Additionally, an extensive immune resource of the at-risk stage and progression to clinical RA with interactive tools was developed to enable further investigation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
Abstract The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293 325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model in each cohort was used to investigate relationships between WHO-defined BMI categories (Underweight: <18.5 kg/m2; Normal: 18.5-24.9 kg/m2; Overweight: 25.0-29.9 kg/m2; Obese I: 30.0-34.9 kg/m2; Obese II: ≥35.0 kg/m2) and risk of incident osteoporotic, major osteoporotic and hip fracture (HF). Inverse-variance weighted β-coefficients were used to merge the cohort-specific results. For the subset with BMD available, in models adjusted for age and follow-up time, the hazard ratio (95% CI) for HF comparing underweight with normal weight was 2.35 (2.10-2.60) in women and for men was 2.45 (1.90-3.17). Hip fracture risk was lower in overweight and obese categories compared to normal weight [obese II vs normal: women 0.66 (0.55-0.80); men 0.91 (0.66-1.26)]. Further adjustment for FN BMD T-score attenuated the increased risk associated with underweight [underweight vs normal: women 1.69 (1.47-1.96); men 1.46 (1.00-2.13)]. In these models, the protective effects of overweight and obesity were attenuated, and in both sexes, the direction of association reversed to higher fracture risk in Obese II category [Obese II vs Normal: women 1.24 (0.97-1.58); men 1.70 (1.06-2.75)]. Results were similar for other fracture outcomes. Underweight is a risk factor for fracture in both men and women regardless of adjustment for BMD. However, while overweight/obesity appeared protective in base models, they became risk factors after additional adjustment for FN BMD, particularly in the Obese II category. This effect in the highest BMI categories was of greater magnitude in men than women. These results will inform the second iteration of FRAX®.
Journal of orthopaedics · 2025
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
International journal of pharmaceutics: X · 2026 · Journal Article
Vu QL, Chiu IH, Do LT, Nguyen TP, et al.
American journal of ophthalmology · 2026 · Journal Article
Espinoza S, Labetoulle M, Rousseau A, Tuil E, et al.
Journal of extracellular biology · 2026 · Journal Article
Bach DH, Bui VG, Nguyen TL
PloS one · 2026 · Journal Article
Tran HTT, Duong TM, Nguyen TV, Le HTT, et al.
Osteoarthritis and cartilage open · 2026 · Journal Article
Hoang DK, Truong AT, Luu LN, Nguyen TD, et al.
Belitung nursing journal · 2026 · Journal Article
Trieu NTT, Hoai NTY, Thuy PT, Dung PTA, et al.
The Journal of infectious diseases · 2026 · Journal Article
Ofotokun I, Titanji K, Dabeer S, Tripathi AK, et al.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2026 · Journal Article
Nguyen TS, Goh KY, Wong PC, Wang PY, et al.
Molecular systems biology · 2025 · Journal Article
Weldy CS, Kundu S, Monteiro J, Gu W, et al.
Journal of imaging informatics in medicine · 2025 · Journal Article
Phan TH, Nguyen TT, Nguyen TD, Pham HH, et al.
Science translational medicine · 2025 · Journal Article
He Z, Glass MC, Venkatesan P, Feser ML, et al.
Clinical genetics · 2026 · Journal Article
Slaiby N, Asmar R, Asmar C, Nguyen T, et al.
Journal of investigative medicine high impact case reports · 2026 · Journal Article
Nguyen NP, Le TDV, Nguyen N, Chakraborty A, et al.
World journal of clinical cases · 2025 · Case Reports
Truong DM, Bui LT, Nguyen TK, Pham HT, et al.
Journal of orthopaedics · 2025 · Journal Article
Nguyen TA, Hogden A, Khanna A, Kuah D
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026 · Journal Article
Schini M, Johansson H, Harvey NC, Lorentzon M, et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025 · Journal Article
Harvey NC, Johansson H, McCloskey EV, Liu E, et al.
Osteoporosis and sarcopenia · 2025 · Published Erratum
Huynh N, de Dios K, Tran TS, Kemp J, et al.
World journal of clinical cases · 2025 · Case Reports
Truong DM, Bui LT, Nguyen TK, Pham HT, et al.
Techniques in hand & upper extremity surgery · 2025 · Journal Article
Strauss G, Nguyen T, Doarn M
Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026 · Journal Article
Diep NT, Duynh NT, Nguyen TV
Pathogens (Basel, Switzerland) · 2026 · Journal Article
Omae SA, Monir SM, Nguyen HT, Huynh KM, et al.
Osteoporosis and sarcopenia · 2026 · Journal Article
Nguyen DM, Wu CH, Nguyen TV, Ho-Pham LT, et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025 · Journal Article
Nguyen HG, Nguyen DT, Tran TS, Ling SH, et al.
Frontiers in bioscience (Landmark edition) · 2026 · Journal Article
Do TT, Nguyen VT, Duong KTT, Truong HG, et al.
Frontiers in medicine · 2025 · Journal Article
Seyal E, Akaa J, O'Dea D, Nguyen T, et al.
Hand (New York, N.Y.) · 2026 · Journal Article
Nguyen T, Hung VT, Hancock JU, Bailey D, et al.
Clinical genetics · 2026 · Journal Article
Slaiby N, Asmar R, Asmar C, Nguyen T, et al.
Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026 · Journal Article
Diep NT, Duynh NT, Nguyen TV
Arthritis care & research · 2025 · Journal Article
Richette P, Walter-Petrich A, Nguyen QD, Resche-Rigon M, et al.
European journal of pain (London, England) · 2025 · Journal Article
Miller VE, Barnhill J, Greco CM, Castro G, et al.
Medicine · 2025 · Journal Article
Huynh TM, Huynh NK, Vo TLT, Lam HT, et al.
Pathogens (Basel, Switzerland) · 2026 · Journal Article
Omae SA, Monir SM, Nguyen HT, Huynh KM, et al.
Rheumatology advances in practice · 2026 · Journal Article
Concoff A, Taiji R, Grinnell-Merrick L, Rodrigues J, et al.
Nephrology (Carlton, Vic.) · 2025 · Consensus Statement
Bose B, Carter SA, Abdy ME, Scholes-Robertson N, et al.
Journal of orthopaedics · 2025 · Journal Article
Nguyen TA, Hogden A, Khanna A, Kuah D
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025 · Journal Article
Cohen SM, Morrison KA, Nguyen TT, Dedeoglu F, et al.
Case reports in nephrology · 2025 · Case Reports
Cao TT, Pham HT, Bui VK, Nguyen TMH, et al.