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Auteur de référence en rhumatologie
21 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
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Frontiers in microbiology · 2022
The rapidly expanding utilization of lanthanides (Ln) for the development of new technologies, green energies, and agriculture has raised concerns regarding their impacts on the environment and human health. The absence of characterization of the underlying cellular and molecular mechanisms regarding their toxicity is a caveat in the apprehension of their environmental impacts. We performed genomic phenotyping and molecular physiology analyses of Saccharomyces cerevisiae mutants exposed to La and Yb to uncover genes and pathways affecting Ln resistance and toxicity. Ln responses strongly differed from well-known transition metal and from common responses mediated by oxidative compounds. Shared response pathways to La and Yb exposure were associated to lipid metabolism, ion homeostasis, vesicular trafficking, and endocytosis, which represents a putative way of entry for Ln. Cell wall organization and related signaling pathways allowed for the discrimination of light and heavy Ln. Mutants in cell wall integrity-related proteins (e.g., Kre1p, Kre6p) or in the activation of secretory pathway and cell wall proteins (e.g., Kex2p, Kex1p) were resistant to Yb but sensitive to La. Exposure of WT yeast to the serine protease inhibitor tosyl phenylalanyl chloromethyl ketone mimicked the phenotype of kex2∆ under Ln, strengthening these results. Our data also suggest that the relative proportions of chitin and phosphomannan could modulate the proportion of functional groups (phosphates and carboxylates) to which La and Yb could differentially bind. Moreover, we showed that kex2∆, kex1∆, kre1∆, and kre6∆ strains were all sensitive to light Ln (La to Eu), while being increasingly resistant to heavier Ln. Finally, shotgun proteomic analyses identified modulated proteins in kex2∆ exposed to Ln, among which several plasmalemma ion transporters that were less abundant and that could play a role in Yb uptake. By combining these different approaches, we unraveled that cell wall components not only act in Ln adsorption but are also active signal effectors allowing cells to differentiate light and heavy Ln. This work paves the way for future investigations to the better understanding of Ln toxicity in higher eukaryotes.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Health economics review · 2025 · Journal Article
Shobha V, Singhai S, Haridas V, V S, et al.
Hip & pelvis · 2024 · Journal Article
Ansari S, Gupta K, Gupta T, Raja BS, et al.
Cureus · 2022 · Journal Article
Muddaloor P, Farinango M, Ansary A, Dakka A, et al.
Cureus · 2022 · Journal Article
Shamim H, Jean M, Umair M, Muddaloor P, et al.
Cureus · 2022 · Journal Article
Dakka A, Nazir Z, Shamim H, Jean M, et al.
Cureus · 2022 · Journal Article
Jean M, Umair M, Muddaloor P, Farinango M, et al.
Hip & pelvis · 2024 · Journal Article
Ansari S, Gupta K, Gupta T, Raja BS, et al.
Cureus · 2022 · Journal Article
Muddaloor P, Farinango M, Ansary A, Dakka A, et al.
Cureus · 2022 · Journal Article
Shamim H, Jean M, Umair M, Muddaloor P, et al.
Cancer medicine · 2025 · Journal Article
Julia MN, David A, Serge P, Fabrice B, et al.
Cureus · 2025 · Journal Article
J N, Gunabooshanam B, Balasubramanian S
African journal of infectious diseases · 2023 · Journal Article
Djakaridja K, Famoussa K, Tatiana YM, Juliette KO, et al.
Cureus · 2024 · Case Reports
Jean M, Paidi R, Paidi G, Akhter S
Cureus · 2022 · Case Reports
Paidi G, Jean M, Oduwole A, Gautam N, et al.
Cureus · 2022 · Journal Article
Muddaloor P, Farinango M, Ansary A, Dakka A, et al.
Cureus · 2022 · Journal Article
Farinango M, Ansary A, Dakka A, Nazir Z, et al.
Cureus · 2024 · Journal Article
Kg G, J R
Frontiers in microbiology · 2022 · Journal Article
Grosjean N, Le Jean M, Chalot M, Mora-Montes HM, et al.
Rheumatology (Oxford, England) · 2025 · Journal Article
Chandwani A, J S, Dwivedi A, Sivasami K, et al.
Cureus · 2022 · Journal Article
Paidi G, Beesetty A, Jean M, Aziz Greye FP, et al.
Cureus · 2025 · Case Reports
K R, J P, R R, B V MM, et al.
Cureus · 2023 · Journal Article
J S, S L, Nair MV, R KT, et al.
Cureus · 2023 · Case Reports
J SK, Waheed MD, Batool S, Holder SS, et al.
Cureus · 2022 · Journal Article
Dakka A, Nazir Z, Shamim H, Jean M, et al.
Cureus · 2022 · Journal Article
Jean M, Umair M, Muddaloor P, Farinango M, et al.
PloS one · 2022 · Journal Article
Sales de Queiroz A, Sales Santa Cruz G, Jean-Marie A, Mazauric D, et al.
Medical education · 2022 · Journal Article
Jazieh KA, Jean-Marie E, Harris AT, McNamara M