📇 Rhumatologue ·

M PIERRE MAMOUSSI

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Auteur de référence en rhumatologie
37 articles scientifiques publiés — un praticien à la pointe de la recherche

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✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Intraoperative Surgical Margin Assessment of Sublobar Lung Resection Specimens Using Computed Tomography

The Annals of thoracic surgery · 2026

📚 3 citations

Response to Pham et al., "Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome"

JAAD international · 2026

📚 1 citations🔓 Open Access

Real-world comparative effectiveness of Bruton tyrosine kinase inhibitors in relapsed/refractory mantle cell lymphoma

Blood advances · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

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Abstract This real-world retrospective cohort study evaluated utilization and comparative effectiveness of covalent Bruton tyrosine kinase inhibitor (cBTKi) monotherapies in relapsed/refractory mantle cell lymphoma (R/R MCL) from electronic health records in the United States. Adults with R/R MCL who received second- or third-line (2L/3L) zanubrutinib, acalabrutinib, or ibrutinib monotherapy, on or after 1 January 2018, were included. Inverse probability of treatment weighting was used in adjusted Cox models to compare real-world time-to-next treatment (rwTTNT) and overall survival (rwOS). Among 698 patients who received 2L/3L cBTKi monotherapy, 49%, 32%, and 19% received acalabrutinib, ibrutinib, and zanubrutinib, respectively. Unadjusted analyses showed median rwTTNT for 2L zanubrutinib, acalabrutinib, and ibrutinib was 14.5 (95% confidence interval [CI], 11.0-23.2), 12.8 (95% CI, 10.5-15.6), and 10.3 (95% CI, 7.6-13.7) months, and median rwOS was 26.4 (95% CI, 23.2 to not reached [NR]), 29.2 (95% CI, 22.9-38.1), and 29.3 (95% CI, 21.8-41.6) months, respectively. Median rwTTNT for 3L zanubrutinib, acalabrutinib, and ibrutinib was 21.1 (95% CI, 3.9 to NR), 9.2 (95% CI, 6.8-14.7), and 9.6 (95% CI, 4.8-18.0) months, and median rwOS was NR (95% CI, 27.3 to NR), 27.4 (95% CI, 15.1-42.2), and 27.0 (95% CI, 15.6 to NR) months, respectively. Adjusted models in the 2L/3L cohorts combined showed numerically longer rwTTNT and statistically significantly longer rwOS for zanubrutinib vs ibrutinib (hazard ratio, 0.63; 95% CI, 0.42-0.96), and trends for improved rwTTNT and rwOS for zanubrutinib over acalabrutinib. Toxicity was a frequent reason for changing to another cBTKi. These findings suggest potential improvements in rwTTNT and rwOS with the use of second- and next-generation cBTKis for R/R MCL from 2018 and beyond.

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M PIERRE MAMOUSSI

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Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (37) — classées par pathologie

Transversal12

Épidémiologie & registres8

Revue générale7

Revue / méta-analyse4

Vraie vie / RWE3

Économie santé2

Qualité de vie / PROMs2

Risque cardio-vasculaire2

Essai clinique1

Fièvres auto-inflammatoires1

Pédiatrie1

Pharmacovigilance1

Santé mentale / fatigue1

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