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Auteur de référence en rhumatologie
28 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
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Proceedings of the National Academy of Sciences of the United States of America · 2018
Significance Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are seen in only a fraction of cancer patients. A key factor that limits therapeutic success is the lack of T cells in tumor cell regions, a profile termed “immune-excluded.” Here, we provide evidence that tumor-associated macrophages (TAMs) are an important determinant of the establishment of a T cell-excluded tumor phenotype. In human and murine tumors, we found that CD8 T cells poorly migrate and invade tumor nests due to long-lasting interactions with TAMs. The depletion of TAMs restores T cell migration and infiltration into tumor islets and improves the efficacy of anti–PD-1 immunotherapy. This study highlights the rationale of combining approaches targeting TAM and immune checkpoint proteins.
Blood advances · 2023
Abstract CD19 chimeric antigen receptor (CAR) T cells can induce prolonged remissions and potentially cure a significant proportion of patients with relapsed/refractory large B-cell lymphomas. However, some patients may die of causes unrelated to lymphoma after CAR T-cell therapy. To date, little is known about the nonrelapse mortality (NRM) after CAR T-cell therapy. Using the French DESCAR-T registry, we analyzed the incidence and causes of NRM and identified risk factors of NRM. We report on 957 patients who received standard-of-care axicabtagene ciloleucel (n = 598) or tisagenlecleucel (n = 359) between July 2018 and April 2022, in 27 French centers. With a median follow-up of 12.4 months, overall NRM occurred in 48 patients (5.0% of all patients): early (before day 28 after infusion) in 9 patients (0.9% of all patients and 19% of overall NRM), and late (on/after day 28 after infusion) in 39 patients (4.1% of all patients and 81% of overall NRM). Causes of overall NRM were distributed as follows: 56% infections (29% with non–COVID-19 and 27% with COVID-19), 10% cytokine release syndromes, 6% stroke, 6% cerebral hemorrhage, 6% second malignancies, 4% immune effector cell associated neurotoxicities, and 10% deaths from other causes. We report risk factors of early NRM and overall NRM. In multivariate analysis, both diabetes and elevated ferritin level at lymphodepletion were associated with an increased risk of overall NRM. Our results may help physicians in patient selection and management in order to reduce the NRM after CAR T-cell therapy.
The Lancet. Global health · 2017
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Science translational medicine · 2026 · Journal Article
Cohen IJ, Bochi-Layec AC, Lemoine J, Jenks S, et al.
The American journal of tropical medicine and hygiene · 2025 · Journal Article
Joseph V, Sutcliffe A, Leite L, Czeher C, et al.
The American journal of tropical medicine and hygiene · 2024 · Journal Article
Hamre KES, Dismer AM, Kishore N, Travers A, et al.
The American journal of tropical medicine and hygiene · 2024 · Journal Article
Désir L, Hamre KES, Beau De Rochars VM, Lemoine JF, et al.
BMC medicine · 2024 · Journal Article
Jaramillo-Underwood A, Herman C, Jean SE, Nace D, et al.
BMJ global health · 2023 · Journal Article
Zoerhoff KL, Mbabazi PS, Gass K, Kraemer J, et al.
PLoS neglected tropical diseases · 2022 · Journal Article
Kostandova N, Desir L, Direny A, Knipes A, et al.
PloS one · 2022 · Journal Article
Louha S, Herman C, Gupta M, Patel D, et al.
European journal of cancer (Oxford, England : 1990) · 2022 · Journal Article
Lemoine J, Vic S, Houot R
The American journal of tropical medicine and hygiene · 2021 · Journal Article
Dismer AM, Lemoine JF, Jean Baptiste M, Mace KE, et al.
The American journal of tropical medicine and hygiene · 2021 · Journal Article
van den Hoogen LL, Herman C, Présumé J, Romilus I, et al.
The American journal of tropical medicine and hygiene · 2020 · Journal Article
Hamre KES, Pierre B, Namuyinga R, Mace K, et al.
The American journal of tropical medicine and hygiene · 2020 · Journal Article
Ashton RA, Joseph V, van den Hoogen LL, Tetteh KKA, et al.
BMC medicine · 2020 · Journal Article
Druetz T, Stresman G, Ashton RA, van den Hoogen LL, et al.
PLoS neglected tropical diseases · 2020 · Journal Article
Wodnik BK, Louis DH, Joseph M, Wilkers LT, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2018 · Journal Article
Peranzoni E, Lemoine J, Vimeux L, Feuillet V, et al.
The American journal of tropical medicine and hygiene · 2017 · Journal Article
Lemoine JF, Boncy J, Filler S, Kachur SP, et al.
Tropical medicine and infectious disease · 2017 · Journal Article
Bardosh KL, Jean L, Beau De Rochars VM, Lemoine JF, et al.
Current research in translational medicine · 2021 · Case Reports
Lemoine J, Bonnin A, Marjanovic Z, van de Wyngaert Z, et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2016 · Case Reports
Tricard T, Bund L, Alhefzi A, Lemoine JP, et al.
Blood advances · 2023 · Journal Article
Lemoine J, Bachy E, Cartron G, Beauvais D, et al.
Malaria journal · 2015 · Comparative Study
Elbadry MA, Al-Khedery B, Tagliamonte MS, Yowell CA, et al.
Tropical medicine and infectious disease · 2018 · Journal Article
Adams AM, Vuckovic M, Birch E, Brant TA, et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2016 · Case Reports
Tricard T, Bund L, Alhefzi A, Lemoine JP, et al.
Malaria journal · 2019 · Journal Article
Briët OJT, Impoinvil DE, Chitnis N, Pothin E, et al.
The Lancet. Global health · 2017 · Journal Article
Steinhardt LC, Jean YS, Impoinvil D, Mace KE, et al.
PLoS neglected tropical diseases · 2020 · Journal Article
Dubray CL, Sircar AD, Beau de Rochars VM, Bogus J, et al.
Malaria journal · 2020 · Journal Article
Daniels RF, Chenet S, Rogier E, Lucchi N, et al.
European journal of cancer (Oxford, England : 1990) · 2025 · Journal Article
Guégan M, Bichon M, Chaput N, Houot R, et al.
PLoS neglected tropical diseases · 2020 · Journal Article
Dubray CL, Sircar AD, Beau de Rochars VM, Bogus J, et al.