📇 Rhumatologue ·

MME Rachel LEJEUNE-SCHOUTEN

Pourquoi vous devez consulter ce praticien

1 raison identifiée

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10000868595

✨ Génération du profil synthétique IA en cours…

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

📊 Comprendre le remboursement

Prendre rendez-vous & contact

🗓 Trouver sur Doctolib 📇 Ajouter à mes contacts

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Chondroitin sulfate: From bioactive molecule to versatile drug delivery system for advancing regenerative medicine

International journal of biological macromolecules · 2025

📚 10 citations🎯 RCR 4.57

MCSP(+) metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

Nature cancer · 2025

📚 7 citations🎯 RCR 2.10🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract To investigate the early, poorly understood events driving metastatic progression, we searched for the earliest detectable disseminated cancer cells (DCCs), also often referred to as disseminated tumor cells (DTCs), in sentinel lymph node (SLN) biopsies of 492 patients with stage I–III melanoma. Using micromanipulator-assisted isolation of rare DCCs, single-cell mRNA and DNA sequencing, codetection by indexing immunofluorescence imaging and survival analysis, we identified melanoma-associated chondroitin sulfate proteoglycan (MCSP) + melanoma cells as metastasis founder cells (MFCs). We found that DCCs entering SLNs predominantly exhibited a transitory phenotype that, upon interferon-γ exposure triggered by CD8 T cells, dedifferentiated into a neural-crest-like phenotype. This was accompanied by increased production of small extracellular vesicles (sEVs) carrying the immunomodulatory proteins CD155 and CD276 but rarely programmed cell death protein 1 ligand 1. The sEVs suppressed CD8 T cell proliferation and function, facilitating colony formation. Targeting MCSP + MFCs or their immune escape mechanisms could be key to curing melanoma early by preventing manifestation of metastasis.

Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells

Scientific reports · 2024

📚 6 citations🎯 RCR 1.67🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractThe application of upconversion nanoparticles (UCNPs) for cell and tissue analysis requires a comprehensive understanding of their interactions with biological entities to prevent toxicity or harmful effects. Whereas most studies focus on cancer cells, this work addresses non-cancerous cells with their regular in vitro physiology. Since it is generally accepted that surface chemistry largely determines biocompatibility in general and uptake of nanomaterials in particular, two bilayer surface coatings with different surface shielding properties have been studied: (i) a phospholipid bilayer membrane (PLM) and (ii) an amphiphilic polymer (AP). Both surface modifications are applied to (12–33) nm core-shell UCNPs NaYF4(Yb, Er)@NaYF4, ensuring colloidal stability in biological media. The impact of UCNPs@AP and UCNPs@PLM on non-cancerous epithelial-like kidney cells in vitro was found to differ significantly. UCNPs@PLM did not exhibit any measurable effect on cell physiology, even with prolonged exposure. In contrast, UCNPs@AP caused changes in cell morphology and induced cell-death after approximately 30 h. These variations in toxicity are attributed to the distinct chemical stability of these particles, which likely influences their intracellular disintegration.

Cookies & analyse de trafic

MME Rachel LEJEUNE-SCHOUTEN

Pourquoi vous devez consulter ce praticien

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal30

Pédiatrie4

Revue générale4

Épidémiologie & registres3

Économie santé2

Vascularites des gros vaisseaux2

Case report / série1

Génétique1

Gériatrie1

Pharmacovigilance1

Revue / méta-analyse1

Santé mentale / fatigue1

SAPL1

Vraie vie / RWE1

Partager cette fiche