📇 Rhumatologue ·
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2 raisons identifiées
Praticien-chercheur
10 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
15
15 articles ont été cités au moins 15fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
1 070
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
42
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
19
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Le Sillon Belge · 18/07/2020
<a href="https://news.google.com/rss/articles/CBMiywFBVV95cUxQVS1XM3RpdGtiUWt3dU9MUFMtTFRmRTZ4ZVROT3ZhYU9pLUpoT0JXVy1wMTRvaXlWSmZvaVJrbThBVVNxcVdibXF4TVBqQmh0MFQyVkpRMHhGSHJac3VpdzNsMmtVQ1Brb2l4U0ZhdWhtZWlkeGdDRTlsUUtBdjRlQlJtVEp0UkNxSUpQSTRuNll5RlZCYnptR05rZzJlbm93V3puNU4wWnNocUliOVJVZ0toZlZiUHViaV
Free radical biology & medicine · 2002
Blood · 2007
AbstractProteinase 3 (PR3), a serine proteinase contained in neutrophil azurophilic granules, is considered a risk factor for vasculitides and rheumatoid arthritis when expressed on the outer leaflet of neutrophil plasma membrane and is the preferred target of antineutrophil cytoplasm autoantibodies (ANCA) in Wegener granulomatosis. ANCA binding to PR3 expressed at the surface of neutrophils activates them. Evidence is provided that neutrophil apoptosis induced significantly more membrane PR3 expression without degranulation (but no enhanced membrane CD35, CD66b, CD63, myeloperoxidase, or elastase expression). This observation was confirmed on cytoplasts, a model of granule-free neutrophils. We hypothesized that PR3 could interact with proteins involved in membrane flip-flop (eg, phospholipid scramblase 1 [PLSCR1]). PR3-PLSCR1 interaction in neutrophils was demonstrated by confocal microscopy and coimmunoprecipitation. In the RBL-2H3 rat mast-cell line stably transfected with PR3 or its inactive mutant (PR3S203A), PR3 externalization depended on PLSCR1, as shown by less PR3 externalization in the presence of rPLSCR1 siRNA, but independently of its serine-proteinase activity. Finally, apoptosis-externalized PR3 decreased the human macrophage-phagocytosis rate of apoptotic PR3 transfectants. Therefore, in addition to ANCA binding in vasculitis, the proinflammatory role of membrane PR3 expression may involve interference with macrophage clearance of apoptotic neutrophils.
Nutrients · 2023
Estrogen deficiency increases the risk of osteoporosis and fracture. The aim of this study was to investigate whether a hop extract standardized in 8-prenylnaringenin (8-PN), a potent phytoestrogen, could improve bone status of osteopenic women and to explore the gut microbiome roles in this effect. In this double-blind, placebo-controlled, randomized trial, 100 postmenopausal, osteopenic women were supplemented with calcium and vitamin D3 (CaD) tablets and either a hop extract (HE) standardized in 8-PN (n = 50) or a placebo (n = 50) for 48 weeks. Bone mineral density (BMD) and bone metabolism were assessed by DXA measurements and plasma bone biomarkers, respectively. Participant’s quality of life (SF-36), gut microbiome composition, and short-chain fatty acid (SCFA) levels were also investigated. In addition to the CaD supplements, 48 weeks of HE supplementation increased total body BMD (1.8 ± 0.4% vs. baseline, p < 0.0001; 1.0 ± 0.6% vs. placebo, p = 0.08), with a higher proportion of women experiencing an increase ≥1% compared to placebo (odds ratio: 2.41 ± 1.07, p < 0.05). An increase in the SF-36 physical functioning score was observed with HE versus placebo (p = 0.05). Gut microbiome α-diversity and SCFA levels did not differ between groups. However, a higher abundance of genera Turicibacter and Shigella was observed in the HE group; both genera have been previously identified as associated with total body BMD. These results suggest that an 8-PN standardized hop extract could beneficially impact bone health of postmenopausal women with osteopenia.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Molecular cancer therapeutics · 2024 · Journal Article
Schiemann K, Belousova N, Matevossian A, Nallaparaju KC, et al.
Journal of medicinal chemistry · 2023 · Journal Article
Buchstaller HP, Sala-Hojman A, Leiendecker M, Albers J, et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020 · Journal Article
Fink C, Lecomte M, Badolo L, Wagner K, et al.
Medicina intensiva · 2017 · Case Reports
Lecomte M, Begot E, Barraud O, Matt M, et al.
Bioorganic & medicinal chemistry letters · 2009 · Journal Article
Lepifre F, Christmann-Franck S, Roche D, Leriche C, et al.
Bioorganic & medicinal chemistry letters · 2009 · Journal Article
Roche D, Carniato D, Leriche C, Lepifre F, et al.
Biochimica et biophysica acta · 2004 · Journal Article
Lecomte M, Denis U, Ruggiero D, Lagarde M, et al.
Free radical biology & medicine · 2002 · Journal Article
Denis U, Lecomte M, Paget C, Ruggiero D, et al.
Nutrients · 2023 · Randomized Controlled Trial
Lecomte M, Tomassi D, Rizzoli R, Tenon M, et al.
Nutrients · 2023 · Randomized Controlled Trial
Lecomte M, Tomassi D, Rizzoli R, Tenon M, et al.
Blood · 2007 · Journal Article
Kantari C, Pederzoli-Ribeil M, Amir-Moazami O, Gausson-Dorey V, et al.
Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery
The performance of eight different methods to predict human volume of distribution (VD<sub>ss</sub>) using a large data set (<i>N</i> > 100) was evaluated.The accuracy was assessed by the end points % within two-fold
Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery
The performance of eight different methods to predict human volume of distribution (VD<sub>ss</sub>) using a large data set (<i>N</i> > 100) was evaluated.The accuracy was assessed by the end points % within two-fold
CCDC 2257778: Experimental Crystal Structure Determination
Related Article: Hans-Peter Buchstaller, Ada Sala-Hojman, Matthias Leiendecker, Joachim Albers, Uwe Anlauf, Nina Berges, Liming Dong, Thomas Fuchß, Martina Germann, Tim Knehans, Mireille Krier, Marc Lecomte, Daniel Mülle
CCDC 2150876: Experimental Crystal Structure Determination
Related Article: Hans-Peter Buchstaller, Ada Sala-Hojman, Matthias Leiendecker, Joachim Albers, Uwe Anlauf, Nina Berges, Liming Dong, Thomas Fuchß, Martina Germann, Tim Knehans, Mireille Krier, Marc Lecomte, Daniel Mülle
CCDC 2240817: Experimental Crystal Structure Determination
Related Article: Hans-Peter Buchstaller, Ada Sala-Hojman, Matthias Leiendecker, Joachim Albers, Uwe Anlauf, Nina Berges, Liming Dong, Thomas Fuchß, Martina Germann, Tim Knehans, Mireille Krier, Marc Lecomte, Daniel Mülle
CCDC 2257777: Experimental Crystal Structure Determination
Related Article: Hans-Peter Buchstaller, Ada Sala-Hojman, Matthias Leiendecker, Joachim Albers, Uwe Anlauf, Nina Berges, Liming Dong, Thomas Fuchß, Martina Germann, Tim Knehans, Mireille Krier, Marc Lecomte, Daniel Mülle
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).