📇 Rhumatologue · LORIENT CEDEX · (56) · Hospitalier

M THOMAS LE DAVADIC

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Auteur de référence en rhumatologie
24 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
141.3 rhumatos / 100 000 hab. — département bien doté

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📍 LORIENT CEDEX (56)HospitalierRPPS 10100901130

✨ Génération du profil synthétique IA en cours…

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GHBS- HÔPITAL DU SCORFF
5 AV DE CHOISEUL BP 12233, 56322 LORIENT CEDEX
☎ 0297069090Activité de soin et de pharmacie

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Top publications · les plus citées

Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus

The world journal of men's health · 2026

📚 7 citations🎯 RCR 7.00🔓 Open Access📄 PDF gratuit ↗

Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Reproductive Medicine

The world journal of men's health · 2026

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

Impact of Positive Resection Margins on Recurrence and Survival After Resection and Adjuvant Chemotherapy in Pancreatic Cancer: Results of the PRODIGE 24-CCTG PA-6 Randomized Controlled Trial

Annals of surgery · 2026

📚 2 citations🩺 Clinique

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Objective: To investigate the correlation between positive resection margins and outcomes in patients with pancreatic ductal adenocarcinoma who underwent surgery and adjuvant chemotherapy according to the pivotal trial PRODIGE 24-CCTG PA-6. Background: The primary focus is on elucidating the prognostic significance of specific resection margins, including those associated with the superior-mesenteric vein, medial, and posterior pancreas. Methods: The analysis involved 400 patients across multiple centers in France and Canada. Surgical resection and subsequent adjuvant chemotherapy were core interventions. This study assessed the prognostic impact of resection margins, highlighting the significance of standardized pathology assessments. In addition, the influence of chemotherapy regimen choice, comparing gemcitabine to mFOLFIRINOX, on the implications of positive resection margins was examined. Results: Only 3 margins, superior-mesenteric vein [hazard ratio (HR) = 1.48 (95% CI: 1.11; 1.96); P < 0.001], medial [HR = 1.92 (95% CI: 1.36; 2.73); P < 0.001] and posterior [HR = 1.65 (95% CI: 1.21; 2.24); P = 0.002], had a significant prognostic impact on disease-free survival and were sufficient compared with the 7 recommended margins (Kappa = 0.90; 95% CI: 0.87; 0.94). R1 status was a significant independent prognostic factor for poorer survival in gemcitabine-treated patients [HR = 1.97 (95% CI: 1.23; 3.16); P = 0.005] but lost its significance with mFOLFIRINOX [HR = 1.46 (95% CI: 0.91; 2.35); P = 0.114]. Conclusions: All efforts should be made to evaluate the 3 margins of the highest prognostic value, with the others being secondary. A key finding of this study is the likely effect of mFOLFIRINOX on local invasion in operated patients, which seems to correct the impairment related to margin involvement, probably explaining the improvements in disease-free survival and overall survival.

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M THOMAS LE DAVADIC

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Top publications · les plus citées

Publications scientifiques (24) — classées par pathologie

Transversal10

Essai clinique3

Pédiatrie3

Revue générale3

Économie santé2

Épidémiologie & registres1

Microbiote1

Qualité de vie / PROMs1

Recommandations1

Santé mentale / fatigue1

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