📇 Rhumatologue · AMIENS · (80) · Libéral

M VALENTIN LAURENT

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11 articles scientifiques publiés — formation continue solide
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126 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 AMIENS (80)LibéralRPPS 10001844256

📊 Reconnaissance scientifique : 10/100📝 32 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

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¹⁸F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: a prospective, randomized, controlled clinical study

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013

📚 51 citations🎯 RCR 2.11Top 25% NIH🩺 Clinique

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ABSTRACT The functional imaging technique of 18F-fluoride positron emission tomography (18F-PET) allows the noninvasive quantitative assessment of regional bone formation at any skeletal site, including the spine and hip. The aim of this study was to determine if 18F-PET can be used as an early biomarker of treatment efficacy at the hip. Twenty-seven treatment-naive postmenopausal women with osteopenia were randomized to receive teriparatide and calcium and vitamin D (TPT group, n = 13) or calcium and vitamin D only (control group, n = 14). Subjects in the TPT group were treated with 20 µg/day teriparatide for 12 weeks. 18F-PET scans of the proximal femur, pelvis, and lumbar spine were performed at baseline and 12 weeks. The plasma clearance of 18F-fluoride to bone, Ki, a validated measurement of bone formation, was measured at four regions of the hip, lumbar spine, and pelvis. A significant increase in Ki was observed at all regions of interest (ROIs), including the total hip (+27%, p = 0.002), femoral neck (+25%, p = 0.040), hip trabecular ROI (+21%, p = 0.017), and hip cortical ROI (+51%, p = 0.001) in the TPT group. Significant increases in Ki in response to TPT were also observed at the lumbar spine (+18%, p = 0.001) and pelvis (+42%, p = 0.001). No significant changes in Kiwere observed for the control group. Changes in BMD and bone turnover markers were consistent with previous trials of teriparatide. In conclusion, this is the first study to our knowledge to demonstrate that 18F-PET can be used as an imaging biomarker for determining treatment efficacy at the hip as early as 12 weeks after initiation of therapy.

The prevalence of inflammatory sacroiliitis assessed on magnetic resonance imaging of inflammatory bowel disease: a retrospective study performed on 186 patients

Alimentary pharmacology & therapeutics · 2014

📚 37 citations🎯 RCR 1.52

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SummaryBackgroundMagnetic resonance imaging (MRI) colonography or enterography is increasingly used to assess disease activity and complications in inflammatory bowel disease (IBD). However, no study has evaluated the role of this imaging technique to assess sacroiliitis.AimThe primary objective was to assess the prevalence of inflammatory sacroiliitis on MRI performed for IBD investigation. The secondary aim was to elucidate clinico‐biological factors associated with the presence of sacroiliitis.MethodsThis study was performed on 186 patients suffering from IBD followed in a gastroenterology department between 2004 and 2011: 131 with Crohn's disease and 55 with ulcerative colitis. Clinico‐biological and endoscopic data were collected and MR enterography or colonography was performed to assess IBD activity on axial and coronal fat suppressed injected T1‐weighted sequences. On MRI, sacroiliitis was scored blindly by two independent readers according to ASAS (Assessment of SpondyloArthritis international Society) criteria.ResultsThe prevalence of inflammatory sacroiliitis was 16.7% (n = 31). Sacroiliitis was bilateral in 14 cases and unilateral in 17 cases. The sacroiliac joints were considered normal in 144 cases and doubtful in 11 cases. Older age and female gender were significantly associated with the presence of sacroiliitis. Other factors such as type of IBD, disease duration and localisation of IBD, surgery history, biological inflammation, bowel disease activity and treatment were not associated with sacroiliitis.ConclusionInflammatory sacroiliitis was evidenced by MRI in 16.7% in patients suffering from IBD. Added to clinico‐biological data, MRI analysis should contribute to an earlier diagnosis of axial spondylarthritis in patients with IBD.

[Value of bone fluoride determination in osteoporotic patients treated with sodium fluoride]

Presse medicale (Paris, France : 1983) · 1989

📚 11 citations

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M VALENTIN LAURENT

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Publications scientifiques (11) — classées par pathologie

Transversal5

Goutte3

Biomarqueurs / Auto-Ac1

Essai clinique1

IRM ostéo-articulaire1

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