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Auteur de référence en rhumatologie
33 articles scientifiques publiés — un praticien à la pointe de la recherche
✨ Génération du profil synthétique IA en cours…
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Arthritis research & therapy · 2015
International archives of allergy and immunology · 2016
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype.
Arthritis care & research · 2016
ObjectiveTo estimate and identify factors associated with the incidence of all‐cause end‐stage renal disease (ESRD) among newly diagnosed systemic lupus erythematosus (SLE) patients.MethodsData from a national registry of treated ESRD were linked to data from a lupus registry of SLE patients who were newly diagnosed and living in Atlanta, Georgia, 2002–2004 (median followup 7.8 years). Cumulative incidence and incidence rates (ESRD treatment initiations per 1,000 patient‐years) were calculated, and age‐ and race‐adjusted Poisson models were used to calculate incidence rate ratios (IRRs).ResultsAmong 344 newly diagnosed SLE patients, 29 initiated ESRD treatment over 2,603.8 years of followup. Incidence rates were 13.8 (95% confidence interval [95% CI] 9.4–20.3) among black patients and 3.3 (95% CI 0.8–13.0) among white patients, per 1,000 patient‐years; corresponding 5‐year cumulative incidence was 6.4% and 2.5% among black and white patients, respectively. Lupus nephritis documented prior to 2005, which occurred in 80% of those who progressed to ESRD, was the strongest risk factor for incident ESRD (IRR 6.7 [95% CI 2.7–16.8]; incidence rate 27.6 per 1,000 patient‐years). Results suggested that patients who were black versus white (IRR 3.9 [95% CI 0.9–16.4]) or <18 years old (versus ≥30 years old) at diagnosis (IRR 2.1 [95% CI 0.9–5.3]) may be more likely to progress to ESRD, but incidence did not differ by sex or other characteristics.ConclusionThe incidence of all‐cause ESRD among patients with a recent diagnosis of SLE is high in Georgia. Interventions to decrease ESRD incidence among newly diagnosed SLE patients should target young and black patients, as well as patients with lupus nephritis.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Neural regeneration research · 2023 · Journal Article
Klein M, Hermey G
Clinical nutrition (Edinburgh, Scotland) · 2022 · Journal Article
Montenegro J, Klein MRST, Bregman R, Prado CM, et al.
PM & R : the journal of injury, function, and rehabilitation · 2021 · Journal Article
Wells K, Klein M, Hurwitz N, Santiago K, et al.
Access microbiology · 2019 · Case Reports
Shalman A, Acker A, Shalman A, Frank D, et al.
PloS one · 2016 · Journal Article
Hurnakova J, Hulejova H, Zavada J, Komarc M, et al.
International archives of allergy and immunology · 2016 · Journal Article
Almanzar G, Klein M, Schmalzing M, Hilligardt D, et al.
Arthritis research & therapy · 2015 · Journal Article
Hurnakova J, Zavada J, Hanova P, Hulejova H, et al.
Arthritis care & research · 2015 · Journal Article
Plantinga LC, Patzer RE, Drenkard C, Kramer MR, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2015 · Journal Article
Plantinga LC, Drenkard C, Patzer RE, Klein M, et al.
American journal of clinical pathology · 2014 · Journal Article
DiCarlo EF, Klein MJ
Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2013 · Journal Article
Histing T, Kuntz S, Stenger D, Scheuer C, et al.
The Journal of surgical research · 2012 · Comparative Study
Histing T, Stenger D, Kuntz S, Scheuer C, et al.
Surgical pathology clinics · 2012 · Journal Article
DiCarlo EF, Klein MJ
Pediatric nephrology (Berlin, Germany) · 2026 · Journal Article
Klein MO, Duncker N, Thews A, Kalab M, et al.
European journal of rheumatology · 2022 · Journal Article
Bakry R, Klein MA, Horneff G
Pediatric rheumatology online journal · 2021 · Journal Article
Doeleman MJH, de Roock S, Buijsse N, Klein M, et al.
Frontiers in pediatrics · 2019 · Journal Article
Fischer KI, Barthel D, Otto C, Ravens-Sieberer U, et al.
Journal of psychosomatic research · 2018 · Journal Article
Barthel D, Ravens-Sieberer U, Nolte S, Thyen U, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018 · Journal Article
Otto C, Barthel D, Klasen F, Nolte S, et al.
Frontiers in pediatrics · 2019 · Journal Article
Fischer KI, Barthel D, Otto C, Ravens-Sieberer U, et al.
Journal of psychosomatic research · 2018 · Journal Article
Barthel D, Ravens-Sieberer U, Nolte S, Thyen U, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018 · Journal Article
Otto C, Barthel D, Klasen F, Nolte S, et al.
PloS one · 2017 · Journal Article
Hurnakova J, Hulejova H, Zavada J, Hanova P, et al.
Arthritis research & therapy · 2017 · Journal Article
Závada J, Hánová P, Hurňáková J, Szczuková L, et al.
BMC ophthalmology · 2014 · Journal Article
Adamus G, Chew EY, Ferris FL, Klein ML
European journal of rheumatology · 2022 · Journal Article
Bakry R, Klein MA, Horneff G
Rheumatology (Oxford, England) · 2015 · Comparative Study
Bulatović Ćalasan M, Vastert SJ, Scholman RC, Verweij F, et al.
Molecular and cellular biochemistry · 2025 · Journal Article
Toyoda Y, Pavelcova K, Masinova J, Hasikova L, et al.
Arthritis research & therapy · 2019 · Letter
Toyoda Y, Pavelcová K, Klein M, Suzuki H, et al.
Arthritis care & research · 2016 · Journal Article
Plantinga L, Lim SS, Patzer R, McClellan W, et al.
Annales d'endocrinologie · 2015 · Journal Article
Diédhiou D, Cuny T, Sarr A, Norou Diop S, et al.
Alternative therapies in health and medicine · 2020 · Journal Article
Klein M, Gonçalves Salum F, Cherubini K, Zancanaro de Figueiredo MA
Clinical lymphoma, myeloma & leukemia · 2011 · Case Reports
Cohen MJ, Shyman A, Klein M, Ben-Yehuda A, et al.
CCDC 1540122: Experimental Crystal Structure Determination
Related Article: Marcel Klein-Hitpaß, Amy D. Lynes, Chris S. Hawes, Kevin Byrne, Wolfgang Schmitt, Thorfinnur Gunnlaugsson|2018|Supramol.Chem.|30|93|doi:10.1080/10610278.2017.1362108
Zwanzig20 - smart³ - Verbundvorhaben: SoundAdapt - adaptive Oberflächenmodule zur anwendungsspezifischen Optimierung der Raumakustik; Teilprojekt TP2: Akustische Konzepte und Entwicklung der FGL-Aktorik : Schlussbericht
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Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Rheumatology (Oxford, England) · 2015 · Comparative Study
Bulatović Ćalasan M, Vastert SJ, Scholman RC, Verweij F, et al.
Arthritis and rheumatism · 2013 · Journal Article
Wehrens EJ, Vastert SJ, Mijnheer G, Meerding J, et al.
Annals of the rheumatic diseases · 2011 · Journal Article
Ronaghy A, de Jager W, Zonneveld-Huijssoon E, Klein MR, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017 · Journal Article
Barthel D, Otto C, Nolte S, Meyrose AK, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016 · Clinical Trial
Barthel D, Fischer KI, Nolte S, Otto C, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017 · Journal Article
Barthel D, Otto C, Nolte S, Meyrose AK, et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016 · Clinical Trial
Barthel D, Fischer KI, Nolte S, Otto C, et al.