📇 Rhumatologue · PARIS CEDEX 15 · (75) · Salarié

M SAMER KAYAL

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4 raisons identifiées

Encadrant universitaire
Forme la prochaine génération de rhumatologues (3 thèses dirigées)
Praticien-chercheur
16 articles scientifiques publiés — formation continue solide
Expérience confirmée
34 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS CEDEX 15 (75)SalariéRPPS 10001480143

EnseignementExpérience confirmée

34ans d'exercice (thèse 1992)

📊 Reconnaissance scientifique : 24/100📝 61 articles publiés🇫🇷 Publications académiques françaises (8)🎓 3 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications

The Journal of experimental medicine · 2003

📚 231 citations🎯 RCR 4.11Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

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The clinical phenotype of interleukin 12 receptor β1 chain (IL-12Rβ1) deficiency and the function of human IL-12 in host defense remain largely unknown, due to the small number of patients reported. We now report 41 patients with complete IL-12Rβ1 deficiency from 17 countries. The only opportunistic infections observed, in 34 patients, were of childhood onset and caused by weakly virulent Salmonella or Mycobacteria (Bacille Calmette-Guérin -BCG- and environmental Mycobacteria). Three patients had clinical tuberculosis, one of whom also had salmonellosis. Unlike salmonellosis, mycobacterial infections did not recur. BCG inoculation and BCG disease were both effective against subsequent environmental mycobacteriosis, but not against salmonellosis. Excluding the probands, seven of the 12 affected siblings have remained free of case-definition opportunistic infection. Finally, only five deaths occurred in childhood, and the remaining 36 patients are alive and well. Thus, a diagnosis of IL-12Rβ1 deficiency should be considered in children with opportunistic mycobacteriosis or salmonellosis; healthy siblings of probands and selected cases of tuberculosis should also be investigated. The overall prognosis is good due to broad resistance to infection and the low penetrance and favorable outcome of infections. Unexpectedly, human IL-12 is redundant in protective immunity against most microorganisms other than Mycobacteria and Salmonella. Moreover, IL-12 is redundant for primary immunity to Mycobacteria and Salmonella in many individuals and for secondary immunity to Mycobacteria but not to Salmonella in most.

The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence

BMC genomics · 2010

📚 84 citations🎯 RCR 2.70Top 19% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackgroundCorynebacterium pseudotuberculosisis generally regarded as an important animal pathogen that rarely infects humans. Clinical strains are occasionally recovered from human cases of lymphadenitis, such asC. pseudotuberculosisFRC41 that was isolated from the inguinal lymph node of a 12-year-old girl with necrotizing lymphadenitis. To detect potential virulence factors and corresponding gene-regulatory networks in this human isolate, the genome sequence ofC. pseudotuberculosisFCR41 was determined by pyrosequencing and functionally annotated.ResultsSequencing and assembly of theC. pseudotuberculosisFRC41 genome yielded a circular chromosome with a size of 2,337,913 bp and a mean G+C content of 52.2%. Specific gene sets associated with iron and zinc homeostasis were detected among the 2,110 predicted protein-coding regions and integrated into a gene-regulatory network that is linked with both the central metabolism and the oxidative stress response of FRC41. Two gene clusters encode proteins involved in the sortase-mediated polymerization of adhesive pili that can probably mediate the adherence to host tissue to facilitate additional ligand-receptor interactions and the delivery of virulence factors. The prominent virulence factors phospholipase D (Pld) and corynebacterial protease CP40 are encoded in the genome of this human isolate. The genome annotation revealed additional serine proteases, neuraminidase H, nitric oxide reductase, an invasion-associated protein, and acyl-CoA carboxylase subunits involved in mycolic acid biosynthesis as potential virulence factors. The cAMP-sensing transcription regulator GlxR plays a key role in controlling the expression of several genes contributing to virulence.ConclusionThe functional data deduced from the genome sequencing and the extended knowledge of virulence factors indicate that the human isolateC. pseudotuberculosisFRC41 is equipped with a distinct gene set promoting its survival under unfavorable environmental conditions encountered in the mammalian host.

Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system

Cellular microbiology · 2005

📚 69 citations🎯 RCR 1.59🔓 Open Access📄 PDF gratuit ↗

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M SAMER KAYAL

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Thèses universitaires

Direction de thèses

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Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (16) — classées par pathologie

Génétique9

Transversal5

Pédiatrie2

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