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3 raisons identifiées
Praticien-chercheur
11 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 4 fois dans les médias — pédagogie reconnue
Expérience confirmée
36 ans d'exercice en rhumatologie — recul clinique solide
36ans d'exercice (thèse 1990)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Direction : Jean-Claude Potier
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
5
5 articles ont été cités au moins 5fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
127
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
15
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
4
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 UQAM · 20/04/2026
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📰 Ouest-France · 14/11/2022
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📰 INFOSuroit.com · 27/05/2018
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📰 lanouvellerepublique.fr · 16/07/2012
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The Journal of experimental medicine · 1994
MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune complex glomerulonephritis. This study examines the role of nitric oxide, a molecule with proinflammatory actions, in the pathogenesis of MRL-lpr/lpr autoimmune disease. MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. In addition, MRL-lpr/lpr peritoneal macrophages had an enhanced capacity to produce nitric oxide in vitro as well as increased nitric oxide synthase activity, and certain tissues from MRL-lpr/lpr mice had increased expression of inducible nitric oxide synthase (NOS) mRNA and increased amounts of material immunoreactive for inducible NOS. Oral administration of NG-monomethyl-L-arginine, a nitric oxide synthase inhibitor, prevented the development of glomerulonephritis and reduced the intensity of inflammatory arthritis in MRL-lpr/lpr mice. By using interspecific backcross mice, the gene for inducible NOS (Nosi) was mapped to mouse chromosome 11. This chromosomal localization was different from those loci that we have previously demonstrated to be linked to enhanced susceptibility to renal disease in an MRL-lpr/lpr cross. However, the chromosomal location of the NOS gene was consistent with an insulin-dependent diabetes locus identified in an analysis of nonobese diabetic (NOD) mice. These results suggest that elevated nitric oxide production could be important in the pathogenesis of autoimmunity, and that treatments to block the production of nitric oxide or block its effects might be valuable therapeutically.
American journal of hypertension · 2001
The Journal of experimental medicine · 1996
Nitric oxide (NO) is an important inflammatory mediator in nonhuman animal models of rheumatoid arthritis (RA). The purpose of the present study was to determine whether blood mononuclear cells from patients with active RA (as compared to control subjects) have higher levels of NO synthase type 2 (NOS2) and produce more NO in vitro. Leukocytes from 25 RA patients and 20 normal subjects were examined. Arthritis activity was assessed by tender and swollen joint counts, duration of morning stiffness, patient assessment of pain, physician and patient global assessment of disease activity, the modified Stanford Health Assessment Questionnaire, and by blood levels of acute phase reactants. Blood mononuclear cell NOS enzyme activity/antigen content and nitrite/nitrate formation in vitro were measured. Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. NOS activity of freshly isolated blood mononuclear cells correlated significantly with disease activity, as assessed by render and swollen joint counts. Our results demonstrate that patients with RA have systemic activation for NOS2 expression, and that the degree of activation correlates with disease activity. Increased NOS2 expression and NO generation may be important in the pathogenesis of RA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Journal of clinical microbiology · 2022 · Journal Article
Sfeir MM, Meece JK, Theel ES, Granger D, et al.
Journal of clinical microbiology · 2021 · Journal Article
Reifert J, Kamath K, Bozekowski J, Lis E, et al.
Lymphatic research and biology · 2004 · Journal Article
Rockson SG, Granger DN, Skeff KM, Chaite W
American journal of hypertension · 2001 · Journal Article
Krieglstein CF, Granger DN
The Journal of experimental medicine · 1996 · Journal Article
St Clair EW, Wilkinson WE, Lang T, Sanders L, et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 1994 · Case Reports
Sulkowski MS, Abolnik IZ, Morris EI, Granger DL
The Journal of experimental medicine · 1994 · Journal Article
Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, et al.
The Yale journal of biology and medicine · 1966 · Case Reports
Keggi KJ, Granger DP, Southwick WO
Inflammation · 1992 · Journal Article
Asako H, Kubes P, Baethge BA, Wolf RE, et al.
Neurology · 1960 · Journal Article
GRANGER DP
Frontiers in immunology · 2022 · Journal Article
Marty PK, Van Keulen VP, Erskine CL, Shah M, et al.